Spatially and temporally distinct encoding of muscle and kinematic information in rostral and caudal primary motor cortex

Kolasinski, James ORCID: https://orcid.org/0000-0002-1599-6440, Dima, Diana C ORCID: https://orcid.org/0000-0002-9612-5574, Mehler, David M A, Stephenson, Alice, Valadan, Sara, Kusmia, Slawomir and Rossiter, Holly E. ORCID: https://orcid.org/0000-0002-5963-701X 2020. Spatially and temporally distinct encoding of muscle and kinematic information in rostral and caudal primary motor cortex. Cerebral Cortex 1 , tgaa009. 10.1093/texcom/tgaa009

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Abstract

The organising principle of human motor cortex does not follow an anatomical body map, but rather a distributed representational structure in which motor primitives are com- bined to produce motor outputs. Electrophysiological recordings in primates and human imaging data suggest that M1 encodes kinematic features of movements, such as joint position and velocity. However, M1 exhibits well-documented sensory responses to cu- taneous and proprioceptive stimuli, raising questions regarding the origins of kinematic motor representations: are they relevant in top-down motor control, or are they an epiphe- nomenon of bottom-up sensory feedback during movement? Here we provide evidence for spatially and temporally distinct encoding of kinematic and muscle information in human M1 during the production of a wide variety of naturalistic hand movements. Using a powerful combination of high-field fMRI and MEG, a spatial and temporal multivariate representational similarity analysis revealed encoding of kinematic information in more caudal regions of M1, over 200 ms before movement onset. In contrast, patterns of muscle activity were encoded in more rostral motor regions much later after movements began. We provide compelling evidence that top-down control of dexterous movement engages kinematic representations in caudal regions of M1 prior to movement production.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	Oxford University Press
ISSN:	1047-3211
Funders:	Wellcome Trust
Date of First Compliant Deposit:	31 March 2020
Date of Acceptance:	25 March 2020
Last Modified:	19 Nov 2023 06:42
URI:	https://orca.cardiff.ac.uk/id/eprint/130667

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