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Enabling protein-hosted organocatalytic transformations

Nödling, Alexander R., Santi, Nicolò ORCID: https://orcid.org/0000-0001-6361-5457, Williams, Thomas L., Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 and Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 2020. Enabling protein-hosted organocatalytic transformations. RSC Advances 10 (27) , pp. 16147-16161. 10.1039/D0RA01526A

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Abstract

In this review, the development of organocatalytic artificial enzymes will be discussed. This area of protein engineering research has underlying importance, as it enhances the biocompatibility of organocatalysis for applications in chemical and synthetic biology research whilst expanding the catalytic repertoire of enzymes. The approaches towards the preparation of organocatalytic artificial enzymes, techniques used to improve their performance (selectivity and reactivity) as well as examples of their applications are presented. Challenges and opportunities are also discussed.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Chemistry
Publisher: Royal Society of Chemistry
ISSN: 2046-2069
Funders: Leverhulme Trust, Royal Society, Wellcome Seed Trust
Date of First Compliant Deposit: 23 April 2020
Date of Acceptance: 25 March 2020
Last Modified: 07 Jun 2023 20:34
URI: https://orca.cardiff.ac.uk/id/eprint/131196

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Cited 4 times in Scopus. View in Scopus. Powered By Scopus® Data

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