Synthesis and biological evaluation of methylene-bridged analogs of the potent cannabinoid receptor antagonist rimonabant

Slusarczyk, Magdalena ORCID: https://orcid.org/0000-0002-4707-7190, De Borggraeve, Wim M., Hoornaert, Georges, Deroose, Frederik and Linders, Joannes T. M. 2008. Synthesis and biological evaluation of methylene-bridged analogs of the potent cannabinoid receptor antagonist rimonabant. European Journal of Organic Chemistry 2008 (8) , pp. 1350-1357. 10.1002/ejoc.200700960

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Abstract

Methylene-bridged analogs of rimonabant were synthesized and evaluated for their activity on CB1 receptors. The pyrazine derivative showed some activity as a CB1 antagonist.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords:	Heterocycles ; Cyclocondensation ; Diels–Alder reaction
Publisher:	Wiley
ISSN:	1434-193X
Last Modified:	21 Oct 2022 09:33
URI:	https://orca.cardiff.ac.uk/id/eprint/36853

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