Neural transplantation in Huntington's disease: the NEST-UK Donor Tissue Microbiological Screening Program and review of the literature

Farrington, M., Wreghitt, T. G., Lever, A. M. L., Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578, Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753 and Barker, R. A. 2006. Neural transplantation in Huntington's disease: the NEST-UK Donor Tissue Microbiological Screening Program and review of the literature. Cell Transplantation 15 (4) , pp. 279-294. 10.3727/000000006783981927

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Abstract

Neural transplantation of human fetal tissue for Huntington's disease (HD) is now entering the clinical arena. The safety of the procedure has now been demonstrated in a number of studies, although the efficacy of such an approach is still being investigated. Stringent but practicable screening of the donor tissue for potential pathogens is an essential prerequisite for successful implementation of any novel transplant program that uses human fetal tissue. In this article we summarize the UK-NEST protocol for the screening of human fetal tissue being grafted to patients with mild to moderate HD. We describe the results of microbiological screening of 87 potential tissue donors in a pilot study, and of the first four donor–recipient patients included in the UK-NEST series. The rationale for the adoption and interpretation of the various tests is described and our methodology is compared with those previously used by other centers. This article therefore presents a comprehensive, logical yet pragmatic screening program that could be employed in any clinical studies that use human fetal tissue for neurotransplantation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	Q Science > QP Physiology R Medicine > R Medicine (General)
Uncontrolled Keywords:	Brain tissue transplantation; Fetal tissue transplantation; Huntington's disease; Microbiological techniques; Tissue transplantation
Publisher:	Ingenta
ISSN:	0963-6897
Last Modified:	27 Oct 2022 08:27
URI:	https://orca.cardiff.ac.uk/id/eprint/62394

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