Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Antagonism of cytotoxic T-lymphocyte activation by soluble CD8

Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Gerth, U. C., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Purbhoo, M. A., Boulter, J. M., Gao, G. F., Bell, J. I., Phillips, R. E. and Jakobsen, B. K. 1999. Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. Nature Medicine 5 , pp. 399-404. 10.1038/7398

Full text not available from this repository.

Abstract

The CD8 co-receptor is important in the differentiation and selection of class I MHC-restricted T cells during thymic development, and in the activation of mature T lymphocytes in response to antigen. Here we show that soluble CD8alphaalpha receptor, despite an extremely low affinity for MHC, inhibits activation of cytotoxic lymphocytes by obstructing CD3 zeta-chain phosphorylation. We propose a model for this effect that involves interference of productive receptor multimerization at the T-cell surface. These results provide new insights into the mechanism of T-cell activation and evidence that CD8 function is exquisitely sensitive to disruption, an effect that might be exploited by molecular therapeutics.

Item Type: Article
Status: Published
Schools: Medicine
Publisher: Nature Publishing Group
ISSN: 1078-8956
Date of First Compliant Deposit: 16 June 2016
Last Modified: 01 Nov 2022 10:31
URI: https://orca.cardiff.ac.uk/id/eprint/91917

Citation Data

Cited 33 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item