In Vivo competence of murine cytomegalovirus under the control of the human cytomegalovirus major immediate-early enhancer in the establishment of latency and reactivation

Gustems, M., Busche, A., Messerle, M., Ghazal, P. ORCID: https://orcid.org/0000-0003-0035-2228 and Angulo, A. 2008. In Vivo competence of murine cytomegalovirus under the control of the human cytomegalovirus major immediate-early enhancer in the establishment of latency and reactivation. Journal of Virology 82 (20) , pp. 10302-10307. 10.1128/JVI.01255-08

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Abstract

The human cytomegalovirus (HCMV) major immediate-early enhancer has been postulated to play a pivotal role in the control of latency and reactivation. However, the absence of an animal model has obstructed a direct test of this hypothesis. Here we report on the establishment of an in vivo, experimentally tractable system for quantitatively investigating physiological functions of the HCMV enhancer. Using a neonate BALB/c mouse model, we show that a chimeric murine CMV under the control of the HCMV enhancer is competent in vivo, replicating in key organs of mice with acute CMV infection and exhibiting latency/reactivation features comparable for the most part to those of the parental and revertant viruses

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	American Society for Microbiology
ISSN:	0022-538X
Date of Acceptance:	29 July 2008
Last Modified:	23 Oct 2022 14:17
URI:	https://orca.cardiff.ac.uk/id/eprint/113282

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