True or false? challenges and recent highlights in the development of aspirin prodrugs

Willetts, Steffan and Foley, David W. ORCID: https://orcid.org/0000-0001-8449-4754 2020. True or false? challenges and recent highlights in the development of aspirin prodrugs. European Journal of Medicinal Chemistry 192 , 112200. 10.1016/j.ejmech.2020.112200

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Abstract

Aspirin is a widely used medicine for a variety of indications. It is unique amongst non-steroidal anti-inflammatory drugs (NSAIDs) in that it causes irreversible acetylation of COX enzymes. Like all NSAIDs however, aspirin causes severe gastrointestinal side-effects, in particular with chronic administration. Prodrugs of aspirin have been proposed as a solution to these side-effects. However, identifying true prodrugs of aspirin, rather than salicylic acid, has proven challenging. This review details the challenges and highlights recent progress in the development of such prodrugs.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Elsevier
ISSN:	0223-5234
Date of First Compliant Deposit:	4 March 2020
Date of Acceptance:	28 February 2020
Last Modified:	06 Nov 2023 19:32
URI:	https://orca.cardiff.ac.uk/id/eprint/130134

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