The effect of simvastatin on novel exploratory biomarkers of cartilage degradation

Quasnichka, H., Budd, E., Tarlton, J., Roberts, S., Jackson, C., Caterson, B. and Mobasheri, A. 2018. The effect of simvastatin on novel exploratory biomarkers of cartilage degradation. Presented at: OARSI 2018 World Congress on Osteoarthritis, Liverpool, UK, 26-29 April 2018. Osteoarthritis and Cartilage. , vol.26 Elsevier, S192. 10.1016/j.joca.2018.02.411

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Abstract

There is emerging evidence of an association between osteoarthritis (OA) and atherosclerosis, with an underlying metabolic syndrome potentially driving the progression of both diseases. Proteomic analysis of OA synovial fluid, degenerative cartilage secretome and chondrocyte membranome has recently identified lumican, chondroadherin and low-density lipoprotein (LRP-1) as potential exploratory markers of joint disease. These biomarker candidates have all been shown to be upregulated in the atherosclerotic plaque, and implicated in pathology. Statin, a classic treatment for atherosclerosis, has been shown to have disease modifying potential in OA, both in clinical and in vitro studies. The aim of this study was to confirm the presence of lumican, chondroadherin and LRP-1 with more targeted analysis, in an explant model of inflammatory cartilage degradation. In addition, we determined whether these proteins, both common to OA and atherosclerosis, are involved in the chondroprotective mechanism of statins; in order to identify novel pathways for a more refined therapeutic intervention.

Item Type:	Conference or Workshop Item (Paper)
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Elsevier
ISSN:	1063-4584
Last Modified:	11 Mar 2023 02:07
URI:	https://orca.cardiff.ac.uk/id/eprint/135452

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