Metabolomics and metabolic function analysis of the secretome of articular cartilage and isolated chondrocytes in response to pro-inflammatory cytokines

Fellows, C., Quasnichka, H., Chowdhury, N. R., Budd, E., Skene, D. J. and Mobasheri, A. 2018. Metabolomics and metabolic function analysis of the secretome of articular cartilage and isolated chondrocytes in response to pro-inflammatory cytokines. Presented at: OARSI 2018 World Congress on Osteoarthritis, Liverpool, UK, 26-29 April 2018. Osteoarthritis and Cartilage. , vol.26 (Supple) Elsevier, S172. 10.1016/j.joca.2018.02.373

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Abstract

Chondrocytes rely primarily on glycolysis to meet their energy requirements, but possess the metabolic flexibility to support cell survival and matrix synthesis during periods of nutrient stress, by enhancing glycolysis with mitochondrial respiration. Accessing this ‘spare respiratory capacity’ requires optimal mitochondrial function, but since impaired mitochondrial function is implicated in osteoarthritis (OA), this mechanism may be deficient or attenuated in joint disease. Metabolic adaptation is evident in early-stage OA, however cartilage from late-stage disease does not seem to have this flexibility. A deeper understanding of these complex metabolic pathways may identify new metabolic markers of disease stage, and support therapeutic strategies for treating OA. Metabolomics has the potential to identify underlying metabolic changes, reveal pathological pathways, novel biomarkers and therapeutic targets. The aim of this study was to identify metabolic processes involved in early stage disease by analysis of metabolites and metabolic function in two inflammatory models of cartilage degradation.

Item Type:	Conference or Workshop Item (Paper)
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Elsevier
ISSN:	1063-4584
Last Modified:	11 Mar 2023 02:07
URI:	https://orca.cardiff.ac.uk/id/eprint/135453

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