%PDF-1.3
%
10 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T0WI2P0T5T R
Ɩf
!\!Y\ !p
o
endstream
endobj
12 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T0WI2P0T5T R
Ɩf
!\!Y\ !p
o
endstream
endobj
5 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T0WI2P0T5T R
Ɩf
!\!Y\ !p
o
endstream
endobj
6 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T0WI2P0T5T R
Ɩf
!\!Y\ !p
o
endstream
endobj
1 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T0WI2P0T5T R
Ɩf
!\!Y\ !p
o
endstream
endobj
8 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T0WI2P0T5T R
Ɩf
!\!Y\ !p
o
endstream
endobj
9 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T0WI2P0T5T R
Ɩf
!\!Y\ !p
o
endstream
endobj
4 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T0WI2P0T5T R
Ɩf
!\!Y\ !p
o
endstream
endobj
13 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T0WI2P0T5T R
Ɩf
!\!Y\ !p
o
endstream
endobj
11 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T0WI2P0T5T R
Ɩf
!\!Y\ !p
o
endstream
endobj
3 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T0WI2P0T5T R
Ɩf
!\!Y\ !p
o
endstream
endobj
7 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T0WI2P0T5T R
Ɩf
!\!Y\ !p
o
endstream
endobj
15 0 obj
<>stream
application/pdf
NEUR-2020-0016-ver9-Pringle_3P 27..38
2021-01-22T10:46:37+05:30
Arbortext Advanced Print Publisher 9.0.114/W
2021-02-11T05:29:14-08:00
Acrobat Distiller 8.1.0 (Windows); modified using iText 4.2.0 by 1T3XT
uuid:a2da7097-cb3c-4a74-9fea-0bab90849cf0
uuid:3b2360a5-dfe9-48e9-bda5-586f35f5e77a
endstream
endobj
16 0 obj
<>stream
x+ |
endstream
endobj
17 0 obj
<>stream
xS**T0T0 Bih uU
endstream
endobj
18 0 obj
<>stream
x+ |
endstream
endobj
19 0 obj
<>stream
xS**T0T0 Bi yn)
endstream
endobj
20 0 obj
<>stream
x+ |
endstream
endobj
21 0 obj
<>stream
xS**T0T0 Bi ye(
endstream
endobj
22 0 obj
<>stream
x+ |
endstream
endobj
23 0 obj
<>stream
xS**T0T0 Bi yJ%
endstream
endobj
24 0 obj
<>stream
x+ |
endstream
endobj
25 0 obj
<>stream
xS**T0T0 Bi y,
endstream
endobj
26 0 obj
<>stream
x+ |
endstream
endobj
27 0 obj
<>stream
xS**T0T0 Bi y8#
endstream
endobj
28 0 obj
<>stream
x+ |
endstream
endobj
29 0 obj
<>stream
xS**T0T0 Bi yS&
endstream
endobj
30 0 obj
<>stream
x+ |
endstream
endobj
31 0 obj
<>stream
xS**T0T0 Bi yw*
endstream
endobj
32 0 obj
<>stream
x+ |
endstream
endobj
33 0 obj
<>stream
xS**T0T0 Bi y+
endstream
endobj
34 0 obj
<>stream
x+ |
endstream
endobj
35 0 obj
<>stream
xS**T0T0 Bi yA$
endstream
endobj
36 0 obj
<>stream
x+ |
endstream
endobj
37 0 obj
<>stream
xS**T0T0 Bih lT
endstream
endobj
38 0 obj
<>stream
x+ |
endstream
endobj
39 0 obj
<>stream
xS**T0T0 Bi y\'
endstream
endobj
41 0 obj
<>stream
/GS1 gs
BT
/F5 1 Tf
10.959 0 0 10.959 62.022 697.8896 Tm
0 0 0 rg
0 Tc
0 Tw
(milieu)Tj
8.2191 0 0 7.3052 89.6315 702.7651 Tm
(4)Tj
10.959 0 0 10.959 95.9244 697.8896 Tm
[(may)-212.3(improve)-213.7(the)-215(outcome)-212.2(after)-217.9(TBI.)-212.7(Therefore,)]TJ
-3.0936 -1.1847 TD
[(understanding)-237.6(the)-235.7(NSC)-237.3(response)-234.6(to)-237.8(TBI)-234.1(has)-240.7(the)-235.7(poten-)]TJ
0 -1.1795 TD
[(tial)-292.6(to)-294.7(identify)-288.7(new)-295.6(therapeutic)-290.9(strategies)-295.2(for)-288.3(the)-292.6(treat-)]TJ
0 -1.1847 TD
[(ment)-298.3(of)-300.5(TBI.)]TJ
.9984 -1.1795 TD
[(Endogenous)-354.7(neurogenesis)-349.5(occurs)-353.2(in)-352.6(the)-349.5(hippocam-)]TJ
-.9984 -1.1847 TD
[(pus)-520.4(and)-519.6(the)-515.1(subventricular)-521.7(zone)-517(\(SVZ\))-520.3(throughout)]TJ
0 -1.1795 TD
(life.)Tj
8.2191 0 0 7.3052 77.7826 625.0392 Tm
(5,6)Tj
10.959 0 0 10.959 92.3527 620.1636 Tm
[(Quiescent)-443.9(precursor)-445.1(cells)-445.7(are)-448.8(present)-444.8(in)-445.7(non-)]TJ
-2.7676 -1.1795 TD
[(permissive)-359.8(regions)-361.3(of)-362.6(the)-359.9(nervous)-360(system)-356.9(such)-362.4(as)-357.8(the)]TJ
0 -1.1847 TD
[(cortex)-348.2(of)-347.1(rodents)]TJ
8.2191 0 0 7.3052 138.274 599.1306 Tm
(710)Tj
10.959 0 0 10.959 158.0598 594.2549 Tm
[(and)-348.8(humans.)]TJ
8.2191 0 0 7.3052 215.8299 599.1306 Tm
(11)Tj
10.959 0 0 10.959 227.5086 594.2549 Tm
[(Within)-345.4(these)-345.5(re-)]TJ
-15.1005 -1.1795 TD
[(gions,)-250.8(a)-256.2(TBI)-249.6(induces)-253.2(neurogenesis)-251.2(of)-254(the)-251.2(normally)-252.4(qui-)]TJ
0 -1.1847 TD
[(escent)-742.1(precursor)-745.1(cells.)]TJ
8.2191 0 0 7.3052 168.1511 573.2219 Tm
(1214)Tj
10.959 0 0 10.959 196.2708 568.3463 Tm
[(Using)-741.6(an)-744.7(organotypic)]TJ
-12.2501 -1.1795 TD
[(stretch)-527.9(injury)-524.7(model)-528.3(for)-526.3(TBI,)-523(we)-526.2(have)-527.3(shown)-527.1(that)]TJ
0 -1.1847 TD
[(after)-311(injury)-307.4(equivalent)-307.9(to)-305.1(a)-307.9(severe)-307.8(TBI,)-305.8(a)-307.9(subset)-312(of)-305.7(en-)]TJ
0 -1.1795 TD
[(dogenous)-298.9(cells)-300.9(acquired)-302.4(stem)-299.4(cell)-302.7(properties)-298.8(in)-300.9(the)-297.8(in-)]TJ
0 -1.1847 TD
[(jured)-516.6(cortex.)]TJ
8.2191 0 0 7.3052 119.7921 521.4046 Tm
(12)Tj
10.959 0 0 10.959 133.3417 516.529 Tm
[(These)-514.6(cells)-513(were)-517(endogenous)-516.2(to)-512(the)]TJ
-6.5079 -1.1795 TD
[(cortex;)-301(they)-300.2(did)-298.5(not)-296.9(migrate)-303.3(from)-298.9(the)-297.8(SVZ.)]TJ
.9984 -1.1795 TD
[(Injury)-487.9(activates)-482.7(a)-489(population)-481.8(of)-486.8(endogenous)-485.2(cells)]TJ
-.9984 -1.1847 TD
[(that)-616.3(display)-620.8(NSC)-615(properties.)-618.8(However,)-614.1(to)-615.5(harness)]TJ
0 -1.1795 TD
[(these)-438.6(cells)-435.4(for)-438.3(repair,)-437(the)-437.5(mechanistic)-433.8(pathways)-438.5(that)]TJ
0 -1.1847 TD
[(contribute)-612.5(to)-615.5(the)-618.5(process)-615.2(need)-616(to)-610.3(be)-615.3(determined.)]TJ
0 -1.1795 TD
[(Manipulation)-237.6(of)-238.5(these)-242(pathways)-236.7(alters)-241.5(the)-235.7(proliferation)]TJ
0 -1.1847 TD
[(of)-357.5(the)-354.7(NSCs,)-358.9(which)-352.7(could)-354.7(lead)-358.3(to)-356.8(improved)-355.8(function.)]TJ
0 -1.1795 TD
[(Previously,)-363.5(we)-360.7(demonstrated)-362.1(a)-359.7(transient)-363.3(upregulation)]TJ
0 -1.1847 TD
[(of)-476.4(sonic)-479.7(hedgehog)-479.3(\(Shh\))-479.3(signaling)-476.5(pathway)-476.5(compo-)]TJ
0 -1.1795 TD
[(nents)-210.5(in)-212.9(the)-209.8(injured)-207.1(cortex.)-213(This)-207.2(was)-213.6(linked)-208.9(with)-206.2(the)-209.8(ac-)]TJ
0 -1.1847 TD
[(quisition)-326.7(of)-326.4(stem)-330.5(cell)-328.6(properties)-324.7(of)-326.4(a)-328.6(subset)-327.5(of)-326.4(cells)-331.9(in)]TJ
0 -1.1795 TD
[(the)-282.3(injured)-279.5(cortex.)]TJ
8.2191 0 0 7.3052 142.696 366.0094 Tm
(20)Tj
10.959 0 0 10.959 153.6944 361.1338 Tm
[(Shh)-275.5(is)-281.3(a)-282.1(member)-275.4(of)-279.9(the)-282.3(hedgehog)]TJ
-8.365 -1.1795 TD
[(family)-316.6(of)-321.2(secreted)-319.3(signaling)-321.3(proteins)-318(and)-317.8(has)-318.3(a)-318.3(role)-322(in)]TJ
0 -1.1847 TD
.0248 Tc
[(adult)-273.3(s).8(tem)-270.3(cell)-273.6(p)1.6(r)-4.4(o)2.3(liferati)]TJ
10.6309 0 TD
.0233 Tc
[(o)-4.4(n).4(.)-276(I)-.7(n)-273.8(r)-.7(od)-5.1(ents)-5.9(,)-270.8(S)-5.3(hh)-273.4(sign)-4.8(al-)]TJ
-10.6309 -1.1795 TD
.0245 Tc
[(ing)-267.6(i)0(s)-268.5(a)-4.1(ctive)-268.2(i)0(n)-272.6(cells)-273.7(that)-273.6(give)-273.4(rise)-273.4(to)-267(neurogenesis)-268.5(in)]TJ
0 -1.1847 TD
.0249 Tc
[(the)-226.4(h)-2.8(ippocampus)]TJ
8.2191 0 0 7.3052 141.222 314.192 Tm
.0309 Tc
[(15)-7.4(,1)-7.4(6)]TJ
10.959 0 0 10.959 162.6519 309.3164 Tm
.0279 Tc
[(an)5(d)-228.1(S)4.4(VZ)5.3(.)]TJ
8.2191 0 0 7.3052 205.1716 314.192 Tm
.0366 Tc
[(17)5.2(1)5.2(9)]TJ
10.959 0 0 10.959 229.0393 309.3164 Tm
.0239 Tc
[(Adult)-232.8(q)1.1(u)-4.5(i)-.6(esc)-5(e).2(nt)]TJ
-15.2402 -1.1795 TD
0 Tc
[(NS)17.2(C)14.5(s)-210.2(pr)20.1(ol)20.6(i)11.7(f)0(e)19(r)0(a)19.8(t)0(e)-197.7(f)0(a)19.3(s)0(t)19.3(e)0(r)-197.7(i)0(n)-202.6(r)12.2(es)19.5(po)21.6(ns)20.4(e)-210(t)0(o)-196.4(S)0(h)16.1(h)]TJ
8.2191 0 0 7.3052 238.3369 301.2661 Tm
(20)Tj
10.959 0 0 10.959 248.4283 296.3904 Tm
[(a)12.8(n)0(d)-201.3(a)12.8(pp)15.7(l)12(i)11.7(ca)20.1(-)]TJ
-17.0094 -1.1847 TD
[(t)12.3(i)0(o)20.2(n)-203.9(o)13.7(f)-200.5(Sh)21.3(h)-198.4(l)0(e)19.3(a)0(d)20.7(s)-199.9(to)]TJ
/F10 1 Tf
7.5994 0 TD
-.0133 Tc
[(de)-213.2(n)-13.3(o)2.8(vo)]TJ
/F5 1 Tf
3.1556 0 TD
0 Tc
[(ne)20.6(ur)20.1(og)16.5(e)12.5(n)0(e)20.6(s)0(i)18.7(s)-199.9(i)11.7(n)-198.8(ne)15.5(o)13.7(c)0(o)21(r)0(t)19.3(e)0(x)-192(o)13.7(f)]TJ
-10.755 -1.1795 TD
[(ad)20.7(ul)19.9(t)-199.8(m)10.2(i)11.7(c)0(e)19.8(.)]TJ
8.2191 0 0 7.3052 108.6803 275.3574 Tm
(21)Tj
10.959 0 0 10.959 118.6582 270.4818 Tm
[(I)12.3(n)-198.8(ad)20.6(di)19.5(ti)18.8(on)-190.2(t)12.3(o)-198.4(i)11.7(n)0(c)20.6(r)0(e)19.5(a)0(s)19.8(i)0(n)19.8(g)-199(ne)20.6(ur)20.1(og)21.7(en)15.5(e)12.5(s)0(i)18.7(s)12.2(,)-201(S)12.8(hh)]TJ
-5.168 -1.1847 TD
.0131 Tc
[(impr)-5.7(ov)-4.8(es)-254(neu)-4.9(r)-.5(it)-5.6(e)-248.6(o)-4.2(utg)-4.8(r)-.5(o)-4.2(w)2.1(th)-252.6(o)-4.2(f)-249.4(n)-4.6(e)-.3(u)-4.9(r)-.5(on)-4.6(s)-254(g).3(ro)-4.2(win)-4.6(g)-253.1(on)-252.9(a)]TJ
0 -1.1795 TD
.0146 Tc
[(monolayer)-200.8(o)-2.7(f)-201.4(r)1(eactive)-200.5(a)1.5(st)-4.1(rocytes.)]TJ
8.2191 0 0 7.3052 208.0629 249.4488 Tm
.0176 Tc
(22)Tj
10.959 0 0 10.959 218.4377 244.5731 Tm
.0146 Tc
[(Thus,)-201.9(S)1.5(hh)-199.3(ac)-3.9(ts)-200.8(as)-200.8(a)]TJ
-14.2728 -1.1795 TD
[(posit)-4(i).5(ve)-334.9(regulator)-335.2(o)2.6(f)-335.8(c)1.3(ell)-330.2(p)-3.3(ro)]TJ
11.9242 0 TD
.0139 Tc
[(lifer)-4.9(a).8(ti)-5.5(on,)-337.1(n)-3.8(eur)-4.9(o)1.8(genesis,)]TJ
-11.9242 -1.1847 TD
.0146 Tc
[(and)-298.3(n)-3.1(euronal)-299.3(m)-1.1(at)-4.1(ura)-3.6(t)1(ion.)]TJ
.9984 -1.1795 TD
0 Tc
[(The)-456.6(signicance)-455.6(of)-455.7(Shh)-456.5(signaling)-455.8(after)-455.9(injury)-457.4(has)]TJ
-.9984 -1.1847 TD
[(been)-418.7(demonstrated.)-418.3(For)-416.3(example,)-420.5(following)-416.8(ischemia)]TJ
0 -1.1795 TD
[(there)-257.6(is)-255.4(an)-253.2(increase)-257.2(of)-259.2(Shh)-254.8(in)-254.3(the)-256.4(brain,)]TJ
8.2191 0 0 7.3052 232.781 184.7054 Tm
(23)Tj
10.959 0 0 10.959 243.496 179.8298 Tm
[(and)-255.7(intrathe-)]TJ
-16.5593 -1.1847 TD
[(cal)-262.7(administration)-266.5(of)-264.3(Shh)-265.1(in)-264.7(a)-266.6(stroke)-260.3(model)-264.5(has)-266.5(shown)]TJ
0 -1.1795 TD
-.0002 Tc
[(a)-421.9(neuroprotective)-419.5(effect.)]TJ
8.2191 0 0 7.3052 170.759 158.7968 Tm
0 Tc
(24)Tj
10.959 0 0 10.959 183.2314 153.9212 Tm
[(Similarly,)-418.5(Shh)-420.3(signaling)-419.6(is)]TJ
-11.0602 -1.1847 TD
[(upregulated)-543.4(in)-538.9(reactive)-541.9(astrocytes)-541.5(following)-535.7(a)-545.9(focal)]TJ
0 -1.1795 TD
[(freeze)-210.7(injury)-209.1(to)-206.8(the)-209.8(cerebral)-210(cortex.)]TJ
8.2191 0 0 7.3052 211.6913 132.8882 Tm
(25)Tj
10.959 0 0 10.959 221.8393 128.0126 Tm
[(Moreover,)-209(this)-208.8(ex-)]TJ
-14.5832 -1.1847 TD
[(pression)-281.9(contributes)-274.4(to)-279.2(an)-284.3(increase)-277.9(in)-280.2(the)-277.1(proliferation)]TJ
0 -1.1795 TD
[(of)-202.3(a)-199.3(subset)-198.2(of)-202.3(progenitor)-198.1(cells,)]TJ
8.2191 0 0 7.3052 189.4109 106.9795 Tm
(25)Tj
10.959 0 0 10.959 199.4456 102.1039 Tm
[(suggesting)-199.3(that)-202.4(Shh)-197.9(sig-)]TJ
-12.5398 -1.1795 TD
[(naling)-285.8(in)-285.4(the)-287.4(injured)-284.7(cortex)-286.2(directly)-283.5(inuences)-288.8(precur-)]TJ
0 -1.1847 TD
[(sor)-370.5(cells.)-367.4(In)-372.7(an)]TJ
/F10 1 Tf
6.4716 0 TD
[(in)-368.1(vitro)]TJ
/F5 1 Tf
3.3833 0 TD
[(model)-368(of)-367.8(a)-370(cortical)-371(astrocytic)]TJ
-9.8549 -1.1795 TD
[(glial)-300.5(scar,)-301.3(stretch)-300.3(injury)-302.2(leads)-299.6(to)-299.9(impaired)-301.3(neurite)-300.5(out-)]TJ
22.9068 57.9085 TD
[(growth)-230.6(of)-233.3(neurons)-230.4(placed)-229.4(upon)-231.4(the)-230.5(stretched)-228.2(astrocytic)]TJ
0 -1.1847 TD
[(layer,)-216(an)21(d)-204.2(t)0(h)20.8(i)0(s)-193.4(w)0(a)17.3(s)-199.9(re)19.5(ve)20.4(rs)19.3(ed)-196.9(b)13.7(y)-204.2(th)20.8(e)-204.8(a)0(d)20.7(d)0(i)19.5(t)0(i)18.8(o)0(n)-195.4(o)13.7(f)-205.6(S)12.8(hh)17(.)]TJ
8.2191 0 0 7.3052 527.1306 689.7825 Tm
(22)Tj
10.959 0 0 10.959 537.1085 684.9069 Tm
(We)Tj
-20.4444 -1.1795 TD
[(ha)16.1(v)13.1(e)-303.1(s)12.2(h)0(o)22.2(w)0(n)-292.6(i)11.7(n)-297.1(o)0(u)16.4(r)]TJ
/F10 1 Tf
7.7391 0 TD
-.0121 Tc
[(in)-314(vi)-12.1(t)6.4(r)-12.1(o)]TJ
/F5 1 Tf
3.1918 0 TD
0 Tc
[(co)21(rt)19.4(i)11.7(c)0(o)21(-)0(h)21.1(i)0(p)19.5(p)0(o)16.4(c)12.5(am)17.8(p)13(a)0(l)-290.7(m)10.2(o)13.7(d)0(e)15.2(l)]TJ
-10.9309 -1.1847 TD
[(th)15.6(a)12.8(t)-236(a)-230.3(s)0(t)19.4(r)0(e)19.5(t)0(c)19.6(h)-234.6(i)11.7(n)0(j)20.2(u)0(r)20.1(y)-235.2(i)11.7(n)0(c)15.5(r)12.2(ea)20.1(se)19.5(s)-236.1(e)12.5(xp)20.6(re)19.5(ss)19.3(io)20.2(n)-235(o)0(f)-223(c)0(o)21(m)10.2(po)21.6(ne)15.5(n)13.3(t)0(s)]TJ
0 -1.1795 TD
[(of)-269.5(t)12.3(h)0(e)-268.7(S)0(h)21.3(h)-276(si)18.7(gn)21.3(al)19.7(in)19.8(g)-276.6(p)0(a)20.6(t)0(h)20.8(w)0(a)17.3(y)13.1(.)]TJ
8.2191 0 0 7.3052 440.3904 650.9479 Tm
-.0169 Tc
(12)Tj
10.959 0 0 10.959 451.162 646.0723 Tm
0 Tc
[(Th)17.2(e)12.5(r)0(e)19.5(f)0(o)20.2(r)0(e)19.5(,)-278.6(we)-267.6(h)13.7(y)0(p)15.8(o)13.7(th)20.8(e-)]TJ
-12.6018 -1.1847 TD
.0235 Tc
[(s)23.5(i)42.2(z)23.5(e)43.3(d)-170.4(t)-.4(hat)-202.2(S)-5.1(hh)-200.8(sig)-4.8(n).6(al)-5.9(ing)-201.4(m)-2.6(ay)-201.4(co)-4.2(ntri)-6.2(bute)-202(t)-5.6(o)-200.7(the)-202(i)-1(n)-4.6(j)-.7(ury)-4.8(-)]TJ
0 -1.1795 TD
.0238 Tc
[(i)-5.9(n).9(duced)-371.9(cell)-367.7(p)-4.6(roli)-5.9(ferat)-5.3(i)-.7(on)-366.4(and)-371.9(N)2.3(SC)-370.4(ac)-5.1(tivat)-5.3(i)-.7(on)-366.4(s)-5.4(een)]TJ
T*
.0249 Tc
[(f)-4.8(o)2.4(llowing)-298.3(a)-298.6(s).9(evere)-304(c)1.2(ortical)-299.3(c)-4(ontusion)-298(injury)-303.4(\(CCI\).)]TJ
1.0036 -1.1847 TD
0 Tc
[(Here,)-417.8(we)-417.6(have)-418.7(demonstrated)-419(that)-419.7(in)-419.9(patients)-417.2(with)]TJ
-1.0036 -1.1795 TD
[(TBI,)-295.4(there)-293.8(is)-296.8(a)-292.4(reduction)-294.4(of)-290.2(Shh)-296.1(protein)-294.1(in)-290.5(cerebrospi-)]TJ
0 -1.1847 TD
[(nal)-215.3(uid)-212.4(\(CSF\))-215.2(compared)-210.5(with)-211.3(control)-210.3(patients.)-214.7(In)-212.4(a)-214.8(ro-)]TJ
0 -1.1795 TD
(dent)Tj
/F10 1 Tf
2.0796 0 TD
[(in)-295.7(vivo)]TJ
/F5 1 Tf
3.0108 0 TD
[(CCI)-295(head)-299.8(injury)-297.1(model,)-294.8(we)-298.6(demonstrated)]TJ
-5.0904 -1.1847 TD
[(that)-295.5(increasing)-293.7(Shh)-296.1(signaling)-295.4(after)-290.3(injury)-297.1(increases)-296.8(the)]TJ
0 -1.1795 TD
[(number)-297.5(of)-295.4(newly)-296.3(proliferating)-298.2(cells)-295.7(in)-295.7(the)-297.8(cortex.)-295.8(This)]TJ
0 -1.1847 TD
[(is)-307.2(accompanied)-296.6(by)-304.3(improvement)-299.9(in)-300.9(motor)-300(function)-302(in)]TJ
0 -1.1795 TD
[(rodents.)-489.4(Thus,)-489.6(manipulating)-492.2(the)-489.2(niche)-489.9(environment)]TJ
T*
[(of)-569.6(the)-566.8(non-permissive)-565.6(injured)-569.2(brain,)-566.7(by)-568.1(increasing)]TJ
0 -1.1847 TD
[(Shh)-394.4(signaling,)-393(may)-393.3(lead)-394.6(to)-393(strategies)-398.7(for)-391.8(endogenous)]TJ
0 -1.1795 TD
[(neural)-301.8(repair)-303.2(and)-297.1(subsequent)-301.2(functional)-297.9(recovery.)]TJ
/F4 1 Tf
10.4607 0 0 10.4607 313.0582 438.8597 Tm
/Cs8 cs 1 scn
(Methods)Tj
/F6 1 Tf
0 -1.2411 TD
[(Shh)-303.9(ELISA)-295.3(in)-302.9(human)-294.7(CSF)]TJ
/F5 1 Tf
10.959 0 0 10.959 313.0582 412.9511 Tm
0 0 0 rg
[(CSF)-337.3(samples)-334.1(were)-336(collected)-331.8(from)-335.1(patients)-334.4(with)-330.3(severe)]TJ
0 -1.1847 TD
[(TBI)-301.3(in)-306.1(which)-300.9(an)-299.8(external)-303.1(ventricular)-302(drain)-299.1(was)-301.6(placed)]TJ
0 -1.1795 TD
[(for)-283.2(the)-282.3(management)-280.6(of)-285(the)-282.3(patients)-282(head)-279.1(injury.)-286(Sam-)]TJ
0 -1.1847 TD
[(ples)-276.1(were)-273.9(taken)-272.3(from)-273(control)-272.3(patients)-272.3(undergoing)-274.5(rou-)]TJ
0 -1.1795 TD
[(tine)-415.8(lumbar)-412.3(puncture)-415.4(for)-417.7(neurological)-411.3(investigations,)]TJ
0 -1.1847 TD
[(the)-277.1(results)-270.5(of)-274.7(which)-269.9(were)-273.9(normal.)-271.6(Samples)-276.7(were)-268.7(stored)]TJ
0 -1.1795 TD
(at)Tj
/F11 1 Tf
1.1174 0 TD
()Tj
/F5 1 Tf
.7708 0 TD
(80)Tj
/F8 1 Tf
.957 0 TD
()Tj
/F5 1 Tf
.3932 0 TD
[(C)-378.6(until)-372.2(analyzed.)-378.3(The)-373.8(Shh)-378.9(concentration)-371.8(was)]TJ
-3.2384 -1.1795 TD
-.0001 Tc
[(determined)-482.2(by)-480.3(enzyme-linked)-478.5(immunosorbent)-479.6(assay)]TJ
0 -1.1847 TD
0 Tc
[(\(ELISA;)-468.9(Human)-463.3(Shh)-461.7(N-terminus)-465(Quantikine)-461.3(ELISA)]TJ
0 -1.1795 TD
[(Kit,)-292.2(DSHH00,)-287(Bio-Techne\))-292.4(according)-288.7(to)-289.5(the)-287.4(manufac-)]TJ
0 -1.1847 TD
[(turers)-245.5(instructions.)-241.9(All)-240.8(samples)-246.2(were)-237.7(obtained)-243.6(with)-242.4(in-)]TJ
0 -1.1795 TD
[(formed)-511.3(consent)-515.4(and)-509.2(according)-511.1(to)-512(guidelines)-511.2(of)-512.7(the)]TJ
0 -1.1847 TD
[(National)-300.1(Research)-301.2(Ethics)-296.5(Committee)-298.9(\(10/H0502/53\).)]TJ
/F6 1 Tf
10.4607 0 0 10.4607 313.0582 231.5905 Tm
/Cs8 cs 1 scn
[(Human)-299.3(tissue)-300.7(polymerase)-303.3(chain)-299(reaction)-298.7(\(PCR\))]TJ
/F5 1 Tf
10.959 0 0 10.959 313.0582 218.6645 Tm
0 0 0 rg
[(Normal)-333(cortical)-334.8(tissue)-334.7(was)-337.8(resected)-334.8(from)-329.9(ve)-338.4(patients)]TJ
T*
[(during)-425.4(access)-416.8(for)-422.8(epilepsy)-417.3(or)-424.1(tumor)-414.5(surgery.)-423(All)-421.9(pa-)]TJ
0 -1.1795 TD
[(tients)-608.5(provided)-601.3(informed)-605.3(consent)-603.3(for)-603.9(participation)]TJ
0 -1.1847 TD
[(and)-250.5(the)-251.2(human)-247.4(brain)-251.8(tissue)-252(samples)-246.2(were)-253.2(anonymized.)]TJ
0 -1.1795 TD
[(Ethical)-206.3(approval)-197.3(was)-203.3(obtained)-202.2(from)-200.6(the)-204.7(Research)-197.8(Ethics)]TJ
T*
[(Committee)-624.8(\(12/NW/0)-628.4(794)-627.1(and)-623(07/H0504/195\).)-625.1(In)]TJ
0 -1.1847 TD
[(three)-428.3(cases,)-423.4(hippocampal)-420.3(tissue)-422.7(was)-425.7(also)-420(taken)-427.5(from)]TJ
0 -1.1795 TD
[(the)-303(same)-299(patient.)]TJ
1.0036 -1.1847 TD
[(Tissue)-597(was)-596.5(transferred)-602.8(in)-595.8(ice-cold)-597.9(articial)-597.1(CSF)]TJ
-1.0036 -1.1795 TD
[(\(aCSF\))-435.2(and)-436.8(placed)-431.1(directly)-433.5(into)-435.2(TRIzol)-433.8(\(Invitrogen\).)]TJ
0 -1.1847 TD
[(Total)-819.9(RNA)-820.8(was)-818.9(extracted)-823.5(and)-819.6(directly)-821.5(reverse-)]TJ
0 -1.1795 TD
[(transcribed)-384(to)-382.7(complementary)-382.9(DNA)-379.9(\(cDNA\))-385(using)-381.5(a)]TJ
0 -1.1847 TD
[(Precision)-326.3(qScript)-320.8(RT)-324(Kit)-324(\(Primer)-319.2(Design\).)-323.3(The)-322(cDNA)]TJ
/F7 1 Tf
7.9702 0 0 7.9702 62.022 755.2061 Tm
[(Pringle)-298.4(et)-293.7(al.;)-304.2(Neurotr)10.7(auma)-298.3(Reports)]TJ
/F6 1 Tf
14.5464 0 TD
[(2021,)-295.3(2.1)]TJ
-14.5464 -1.2021 TD
[(http://onl)9.4(ine.liebertpu)9.7(b.com/doi/1)9.2(0.1089/neur.2)11.5(020.0016)]TJ
60.483 1.2021 TD
(28)Tj
ET
/EmbeddedDocument /MC7 BDC
/Document /MC8 BDC
q
1 i
572.031 35.263 10.035 -19.162 re
W n
1 .64 .53 .47 k
q 1 0 0 1 572.031 16.06 cm 0 0 m
.966 3.153 1.461 4.22 v
1.739 4.818 2.425 6.378 3.087 7.332 c
3.497 7.924 4.368 8.916 4.541 9.195 c
4.633 9.338 4.701 9.556 y
4.901 9.641 5.09 9.748 v
5.279 9.855 5.638 10.053 5.702 10.239 c
5.807 10.549 5.997 10.624 y
6.187 10.665 6.271 10.678 v
6.44 10.699 6.566 10.772 6.735 10.858 c
6.904 10.945 7.12 11.061 7.516 11.253 c
7.799 11.391 10.08 12.245 y
10.048 12.161 9.858 12.011 v
9.667 11.862 9.25 11.707 9.083 11.621 c
8.914 11.536 7.475 10.816 7.199 10.645 c
6.926 10.474 6.091 9.925 5.47 9.365 c
5.02 8.959 4.51 8.356 4.184 7.914 c
3.263 6.665 2.748 5.394 y
3.551 5.415 3.613 5.415 v
3.676 5.415 3.845 4.924 y
3.212 5.01 2.938 4.861 v
2.663 4.712 2.592 4.659 2.358 4.273 c
2.129 3.895 1.618 2.108 1.314 1.137 c
1.22 .833 1.125 .399 .936 .305 c
.813 .243 0 0 y
f
Q
Q
1 .64 .53 .47 K
1 J 0 j .405 w 4 M []0 d
/GS2 gs
1 i
q 1 0 0 1 577.63 22.437 cm 0 0 m
.403 .006 .637 -.007 v
.776 -.013 .996 -.05 1.152 -.097 c
1.288 -.142 1.451 -.222 1.542 -.287 c
1.659 -.373 1.711 -.47 1.783 -.568 c
1.832 -.637 1.991 -1.045 2.063 -1.095 c
2.136 -1.142 2.146 -1.179 2.081 -1.223 c
2.03 -1.257 2.004 -1.324 1.984 -1.373 c
1.965 -1.424 1.89 -1.613 1.84 -1.767 c
1.802 -1.888 1.742 -1.958 1.704 -2.004 c
1.646 -2.071 1.529 -2.169 1.405 -2.236 c
1.312 -2.285 1.146 -2.357 .995 -2.389 c
.716 -2.45 .292 -2.479 .174 -2.469 c
S
Q
1 .64 .53 .47 k
q 1 0 0 1 576.761 19.775 cm 0 0 m
-.054 0 -.095 .02 -.095 .045 c
-.095 .068 -.054 .088 0 .088 c
.05 .088 .094 .068 .094 .045 c
.094 .02 .05 0 0 0 c
-.35 .372 m
-.35 .416 -.271 .451 -.175 .451 c
-.08 .451 0 .416 0 .372 c
0 .328 -.08 .292 -.175 .292 c
-.271 .292 -.35 .328 -.35 .372 c
-.46 .766 m
-.46 .826 -.36 .874 -.238 .874 c
-.116 .874 -.018 .826 -.018 .766 c
-.018 .705 -.116 .656 -.238 .656 c
-.36 .656 -.46 .705 -.46 .766 c
-.586 1.181 m
-.586 1.262 -.477 1.325 -.34 1.325 c
-.206 1.325 -.095 1.262 -.095 1.181 c
-.095 1.101 -.206 1.035 -.34 1.035 c
-.477 1.035 -.586 1.101 -.586 1.181 c
-.19 1.641 m
-.19 1.586 -.269 1.545 -.364 1.545 c
-.462 1.545 -.539 1.586 -.539 1.641 c
-.539 1.69 -.462 1.732 -.364 1.732 c
-.269 1.732 -.19 1.69 -.19 1.641 c
-.373 2.112 m
-.265 2.112 -.175 2.066 -.175 2.012 c
-.175 1.954 -.265 1.908 -.373 1.908 c
-.481 1.908 -.569 1.954 -.569 2.012 c
-.569 2.066 -.481 2.112 -.373 2.112 c
-.303 2.491 m
-.215 2.491 -.143 2.459 -.143 2.418 c
-.143 2.379 -.215 2.347 -.303 2.347 c
-.39 2.347 -.46 2.379 -.46 2.418 c
-.46 2.459 -.39 2.491 -.303 2.491 c
-.175 2.753 m
-.131 2.753 -.095 2.735 -.095 2.708 c
-.095 2.688 -.131 2.666 -.175 2.666 c
-.22 2.666 -.255 2.688 -.255 2.708 c
-.255 2.735 -.22 2.753 -.175 2.753 c
1.513 .335 m
1.371 .352 1.288 .352 1.196 .352 c
1.101 .352 1.021 .346 .69 .352 c
.478 .354 .535 .471 .729 .496 c
.809 .506 .849 .51 .896 .518 c
.944 .525 .991 .531 1.212 .576 c
1.433 .62 1.308 .699 1.138 .711 c
1.009 .719 .952 .722 .903 .722 c
.824 .722 .78 .724 .569 .738 c
.3 .763 .425 .881 .548 .904 c
.611 .914 .637 .918 .675 .926 c
.715 .935 .738 .941 .984 .977 c
1.229 1.013 1.118 1.098 .976 1.109 c
.833 1.126 .809 1.13 .741 1.134 c
.68 1.137 .642 1.136 .471 1.158 c
.312 1.181 .375 1.266 .461 1.285 c
.547 1.307 .606 1.32 .661 1.321 c
.694 1.324 .723 1.33 .889 1.355 c
1.113 1.388 1.118 1.479 .868 1.512 c
.743 1.529 .723 1.53 .698 1.533 c
.661 1.54 .64 1.545 .44 1.566 c
.251 1.588 .304 1.698 .471 1.72 c
.589 1.734 .658 1.743 .69 1.749 c
.723 1.752 .77 1.752 .929 1.77 c
1.143 1.795 1.156 1.898 .936 1.918 c
.809 1.933 .797 1.93 .745 1.934 c
.715 1.937 .705 1.933 .485 1.953 c
.286 1.97 .358 2.07 .494 2.092 c
.62 2.112 .71 2.128 .802 2.142 c
.833 2.146 .858 2.14 1.131 2.2 c
1.284 2.232 1.25 2.307 1.068 2.315 c
1.002 2.32 .884 2.331 .793 2.339 c
.715 2.347 .666 2.347 .517 2.359 c
.366 2.373 .494 2.484 .548 2.498 c
.604 2.514 .84 2.535 .965 2.543 c
1.094 2.55 1.284 2.556 1.394 2.586 c
1.492 2.614 1.433 2.673 1.338 2.695 c
1.29 2.705 1.261 2.713 1.182 2.728 c
1.101 2.742 1.046 2.745 .965 2.761 c
.872 2.78 .889 2.769 .849 2.789 c
.809 2.814 .759 2.898 y
.729 2.985 .683 2.985 v
.636 2.985 .563 2.987 .421 2.987 c
.28 2.987 .326 2.994 .265 2.994 c
.2 2.994 .112 3.01 .026 3.016 c
-.061 3.024 -.171 3.03 -.227 3.024 c
-.281 3.016 -.358 2.992 -.417 2.959 c
-.504 2.906 -.622 2.777 -.692 2.695 c
-.764 2.614 -.875 2.397 -.915 2.323 c
-.954 2.251 -1.08 1.887 -1.129 1.808 c
-1.175 1.727 -1.302 1.675 y
-1.511 1.573 -1.387 1.54 v
-.964 1.423 -1.325 1.269 y
-1.31 1.172 l
-1.27 1.172 -1.262 1.153 v
-1.254 1.13 -1.129 1.158 -1.024 .874 c
-.977 .742 -.933 .651 -.85 .468 c
-.811 .38 -.677 .053 -.446 -.092 c
-.195 -.252 .012 -.207 .121 -.194 c
.251 -.181 .471 -.128 .581 -.125 c
.723 -.114 .763 -.114 .88 -.107 c
.999 -.099 1.361 -.092 y
.873 0 .778 0 v
.683 0 1.007 .094 1.142 .116 c
1.261 .139 1.378 .168 y
1.418 .184 1.553 .211 v
1.688 .242 1.655 .321 1.513 .335 c
f
Q
q
572.031 35.263 10.035 -19.162 re
W n
0 J
q 1 0 0 1 576.744 25.907 cm 0 0 m
-.066 -.119 -.079 -.096 v
-.122 .003 -.244 .254 -.395 .343 c
-.586 .454 -1.661 .89 -1.821 .965 c
-1.948 1.026 -2.464 1.133 -2.75 1.614 c
-3.04 2.104 -3.099 2.207 -3.229 2.355 c
-3.403 2.553 -3.277 2.712 -3.07 2.738 c
-2.962 2.752 -2.821 2.753 -2.718 2.753 c
-2.656 2.754 -2.654 2.877 -2.658 3.009 c
-2.668 3.222 -2.723 3.28 -2.881 3.41 c
-3.04 3.536 -3.323 3.744 -3.387 3.921 c
-3.451 4.096 -3.373 4.398 -3.53 4.526 c
-3.687 4.656 -4.023 4.897 -4.1 5.244 c
-4.164 5.532 -4.025 5.669 -3.927 5.723 c
-3.772 5.808 -3.609 5.804 -3.482 5.676 c
-3.354 5.549 -3.341 5.389 -3.277 5.311 c
-3.214 5.229 -3.051 5.181 -2.976 5.149 c
-2.875 5.106 -2.769 5.065 -2.643 5.032 c
-2.598 5.021 -2.38 4.925 -2.339 5.021 c
-2.302 5.102 -2.351 5.196 -2.389 5.311 c
-2.47 5.532 -3.008 5.771 -3.07 5.837 c
-3.134 5.899 -3.335 6.063 -3.403 6.377 c
-3.467 6.671 -3.468 6.71 -3.53 6.857 c
-3.637 7.108 -3.585 7.299 -3.552 7.427 c
-3.51 7.591 -3.627 7.705 -3.547 7.8 c
-3.446 7.916 -3.299 7.981 -3.198 7.911 c
-3.122 7.856 -3.023 7.773 -2.96 7.726 c
-2.895 7.676 -2.854 7.64 -2.707 7.554 c
-2.596 7.489 -2.439 7.54 -2.327 7.512 c
-2.242 7.489 -2.082 7.349 -2.074 7.364 c
-2.025 7.443 -2.058 7.561 -2.074 7.688 c
-2.09 7.814 -2.216 8.07 -2.247 8.151 c
-2.28 8.23 -2.31 8.359 -2.231 8.469 c
-2.153 8.582 -1.963 8.82 -1.868 8.932 c
-1.773 9.045 -1.661 9.284 -1.504 9.061 c
-1.344 8.836 -1.282 8.694 -1.202 8.646 c
-1.124 8.597 -1.039 8.597 -.917 8.63 c
-.799 8.661 -.646 8.694 -.537 8.726 c
-.426 8.755 -.346 8.836 -.252 8.902 c
-.157 8.965 -.093 8.98 -.03 8.948 c
.033 8.917 .059 8.874 .097 8.789 c
.122 8.729 .122 8.63 .144 8.55 c
.184 8.396 .229 8.322 .207 8.263 c
.159 8.129 .065 8.024 .033 7.927 c
0 7.831 .059 7.567 .018 7.496 c
-.046 7.383 -.109 7.352 -.141 7.239 c
-.173 7.13 -.141 7.001 -.093 6.905 c
-.046 6.811 -.046 6.714 -.03 6.634 c
-.014 6.554 .082 6.603 .144 6.681 c
.207 6.762 .207 6.841 .271 6.953 c
.334 7.064 .491 7.064 .635 7.082 c
.764 7.095 .925 7.258 1.063 7.273 c
1.141 7.281 1.285 7.242 1.348 7.13 c
1.442 6.957 1.458 6.793 1.378 6.664 c
1.3 6.539 1.18 6.429 1.143 6.282 c
1.094 6.097 1.074 5.872 .968 5.723 c
.866 5.581 .727 5.501 .635 5.358 c
.533 5.191 .508 4.877 .555 4.718 c
.604 4.558 .661 4.602 .698 4.687 c
.746 4.795 .787 4.904 .888 4.957 c
1.086 5.061 1.327 5.17 1.475 5.181 c
1.554 5.186 1.712 5.102 1.775 4.973 c
1.839 4.846 1.816 4.657 1.79 4.526 c
1.737 4.276 1.671 4.01 1.602 3.921 c
1.505 3.796 1.391 3.694 1.237 3.584 c
1.08 3.473 .715 3.298 .57 3.201 c
.407 3.091 .323 2.923 .292 2.797 c
.261 2.673 .302 2.578 .382 2.578 c
.46 2.578 .555 2.721 .604 2.785 c
.65 2.851 .705 2.992 .798 3.009 c
.904 3.03 1.031 2.963 1.143 2.963 c
1.253 2.963 1.316 3.009 1.442 3.042 c
1.569 3.073 1.649 2.999 1.632 2.871 c
1.616 2.744 1.616 2.674 1.553 2.593 c
1.49 2.513 1.316 2.419 1.3 2.307 c
1.284 2.194 1.318 2.064 1.3 1.972 c
1.273 1.838 1.143 1.747 1.016 1.635 c
.888 1.525 .46 1.179 .367 .981 c
.3 .844 .3 .566 .318 .454 c
.345 .294 .398 .262 y
.431 .262 .132 .139 .121 .127 c
.047 .055 0 0 y
h
S 1 0 0 1 1.403 6.747 cm 0 0 m
.079 .046 .119 .094 .222 .199 c
.324 .301 .436 .422 .505 .501 c
.559 .56 .696 .684 .768 .806 c
.828 .905 .87 .941 .95 .949 c
.997 .953 1.107 .949 1.164 .972 c
1.22 .996 1.367 1.077 1.417 1.115 c
1.456 1.149 1.679 1.195 1.728 1.021 c
1.777 .829 1.784 .588 1.757 .526 c
1.693 .374 1.6 .262 1.552 .11 c
1.522 .022 1.527 -.153 1.583 -.312 c
1.633 -.459 1.703 -.393 1.798 -.337 c
1.893 -.281 1.964 -.25 2.041 -.258 c
2.121 -.266 2.462 -.312 2.51 -.322 c
2.556 -.328 2.636 -.37 2.612 -.449 c
2.589 -.527 2.431 -.817 2.312 -.92 c
2.192 -1.024 2.105 -1.111 2.083 -1.175 c
2.058 -1.238 1.995 -1.406 1.985 -1.487 c
1.979 -1.566 1.853 -1.718 1.78 -1.765 c
1.709 -1.812 1.393 -2.014 1.346 -2.054 c
1.299 -2.091 1.11 -2.161 1.274 -2.349 c
1.393 -2.484 1.4 -2.421 1.456 -2.413 c
1.513 -2.403 1.545 -2.391 1.646 -2.324 c
1.757 -2.254 1.86 -2.229 1.972 -2.277 c
2.083 -2.324 2.163 -2.357 2.192 -2.403 c
2.257 -2.499 2.202 -2.581 2.176 -2.62 c
2.146 -2.671 1.868 -2.946 1.813 -3.003 c
1.757 -3.059 1.527 -3.259 1.456 -3.315 c
1.387 -3.371 1.22 -3.529 1.171 -3.633 c
1.124 -3.738 1.068 -3.953 1.021 -4.034 c
.974 -4.113 .775 -4.295 .607 -4.407 c
.442 -4.52 .135 -4.736 .071 -4.847 c
.027 -4.922 -.008 -5.127 -.025 -5.288 c
-.04 -5.446 0 -5.589 y
-.119 -5.614 -.205 -5.638 v
-.294 -5.662 -.364 -5.741 -.364 -5.798 c
-.364 -5.853 -.491 -5.988 y
-.477 -5.853 -.554 -5.766 v
-.634 -5.676 -.713 -5.567 -.761 -5.542 c
S
Q
Q
q 1 0 0 1 576.579 25.908 cm 0 0 m
.054 .175 l
-.08 .388 -.135 .459 v
-.19 .531 -.809 1.001 -.901 1.074 c
-.995 1.145 -1.305 1.351 -1.409 1.39 c
-2.032 1.677 -2.075 1.693 v
-2.12 1.712 -2.419 1.883 -2.468 1.909 c
-2.517 1.936 -2.639 2.005 -2.678 2.031 c
-2.715 2.059 -2.748 2.122 -2.748 2.148 c
-2.748 2.176 -2.731 2.227 -2.71 2.221 c
-2.687 2.216 -2.639 2.221 -2.616 2.197 c
-2.596 2.176 -2.507 2.138 -2.456 2.109 c
-2.406 2.081 -2.037 1.901 -1.993 1.879 c
-1.949 1.854 -1.623 1.689 -1.574 1.671 c
-1.523 1.654 -1.294 1.545 -1.255 1.522 c
-1.217 1.501 -1.133 1.445 -1.077 1.418 c
-1.021 1.39 -.901 1.316 -.873 1.297 c
-.848 1.272 -.72 1.179 -.692 1.145 c
-.664 1.114 -.477 .996 -.454 .978 c
-.433 .964 -.301 .836 -.278 .825 c
-.257 .813 -.18 .759 -.162 .754 c
-.146 .747 -.112 .729 -.092 .74 c
-.067 .754 -.057 .818 -.063 .852 c
-.067 .886 -.162 1.346 -.18 1.424 c
-.194 1.501 -.262 1.833 -.278 1.888 c
-.296 1.942 -.41 2.109 -.516 2.187 c
-.619 2.266 -1.105 2.664 -1.166 2.702 c
-1.227 2.739 -1.508 2.946 -1.585 2.984 c
-1.663 3.024 -1.91 3.179 -1.977 3.223 c
-2.044 3.268 -2.374 3.495 -2.43 3.545 c
-2.484 3.594 -2.864 4.004 -2.936 4.082 c
-3.009 4.16 -3.274 4.55 -3.332 4.646 c
-3.393 4.747 -3.538 4.891 -3.603 4.974 c
-3.671 5.057 -3.734 5.167 -3.741 5.207 c
-3.746 5.247 -3.696 5.334 -3.603 5.258 c
-3.511 5.179 -3.454 5.124 -3.399 5.086 c
-3.344 5.046 -3.3 5.003 -3.262 4.945 c
-3.224 4.891 -3.151 4.796 -3.123 4.753 c
-3.096 4.708 -2.97 4.515 -2.926 4.454 c
-2.883 4.392 -2.706 4.136 -2.605 4.022 c
-2.507 3.903 -2.253 3.635 -1.784 3.351 c
-1.317 3.068 -.757 2.691 -.697 2.658 c
-.637 2.623 -.592 2.576 -.554 2.576 c
-.516 2.576 -.498 2.598 -.487 2.623 c
-.477 2.652 -.521 2.758 -.544 2.829 c
-.565 2.901 -.603 3.279 -.626 3.383 c
-.648 3.488 -.823 4.42 -.848 4.499 c
-.867 4.575 -.852 4.715 -1.001 4.806 c
-1.148 4.902 -1.547 5.194 -1.618 5.252 c
-1.69 5.306 -2.264 5.859 -2.324 5.927 c
-2.386 5.992 -2.673 6.332 -2.721 6.38 c
-2.771 6.432 -2.941 6.636 -2.981 6.741 c
-3.018 6.846 -3.047 6.912 -3.079 6.99 c
-3.113 7.068 -3.185 7.234 -3.206 7.283 c
-3.228 7.335 -3.25 7.416 -3.245 7.434 c
-3.239 7.45 -3.218 7.473 -3.175 7.45 c
-3.129 7.428 -3.024 7.29 -3.004 7.251 c
-2.981 7.213 -2.876 7.046 -2.858 7.002 c
-2.843 6.958 -2.803 6.868 -2.776 6.823 c
-2.748 6.781 -2.534 6.476 -2.462 6.402 c
-2.391 6.332 -2.147 6.07 -2.087 6.016 c
-2.027 5.961 -1.518 5.449 -1.435 5.379 c
-1.353 5.306 -1.188 5.2 -1.144 5.184 c
-1.101 5.167 -1.057 5.167 -1.035 5.179 c
-1.011 5.189 -.984 5.222 -.99 5.322 c
-.995 5.423 -1.105 6.353 -1.128 6.486 c
-1.148 6.621 -1.271 7.022 -1.3 7.135 c
-1.325 7.245 -1.364 7.571 -1.392 7.794 c
-1.419 8.016 -1.568 8.645 -1.613 8.737 c
-1.657 8.824 -1.686 8.912 -1.705 8.963 c
-1.728 9.012 -1.767 9.105 -1.739 9.152 c
-1.714 9.195 -1.646 9.339 -1.613 9.334 c
-1.579 9.329 -1.534 9.31 -1.514 9.272 c
-1.491 9.233 -1.446 8.984 -1.435 8.935 c
-1.426 8.884 -1.31 8.337 -1.305 8.293 c
-1.3 8.247 -1.242 8.098 -1.232 8.038 c
-1.223 7.976 -1.184 7.728 -1.178 7.622 c
-1.172 7.517 -1.139 7.406 -1.111 7.385 c
-1.083 7.361 -1.05 7.367 -1.018 7.379 c
-.984 7.389 -.945 7.522 -.911 7.583 c
-.88 7.643 -.71 7.905 -.671 7.947 c
-.631 7.991 -.537 8.198 -.516 8.237 c
-.493 8.275 -.388 8.48 -.356 8.535 c
-.321 8.592 -.229 8.714 -.2 8.755 c
-.174 8.79 -.129 8.867 -.102 8.863 c
-.074 8.857 -.009 8.824 y
.048 8.784 .014 8.709 v
-.018 8.63 -.14 8.486 -.174 8.432 c
-.207 8.377 -.345 8.128 -.388 8.026 c
-.433 7.928 -.615 7.711 -.644 7.667 c
-.671 7.622 -.775 7.373 -.813 7.283 c
-.852 7.193 -.919 7.018 -.935 6.924 c
-.95 6.83 -.919 6.396 -.906 6.332 c
-.896 6.265 -.79 5.526 -.78 5.395 c
-.769 5.262 -.736 5.057 -.72 4.997 c
-.702 4.935 -.687 4.764 -.676 4.663 c
-.664 4.564 -.659 4.509 -.631 4.481 c
-.603 4.454 -.565 4.447 -.544 4.465 c
-.521 4.481 -.382 4.698 -.349 4.747 c
-.316 4.796 -.169 5.04 -.146 5.067 c
-.123 5.097 .108 5.35 .18 5.407 c
.253 5.461 .394 5.59 .449 5.683 c
.505 5.776 .561 5.882 .621 6.032 c
.681 6.182 .731 6.409 .77 6.47 c
.81 6.529 .896 6.697 .931 6.741 c
.963 6.787 1.14 7.002 1.194 7.033 c
1.25 7.068 1.305 7.117 1.338 7.117 c
1.37 7.117 1.403 7.074 1.397 7.04 c
1.394 7.008 1.338 6.944 1.315 6.92 c
1.296 6.891 1.129 6.691 1.101 6.636 c
1.072 6.581 .913 6.265 .896 6.192 c
.88 6.121 .831 5.91 .798 5.844 c
.764 5.776 .72 5.667 .647 5.566 c
.576 5.467 .466 5.362 .372 5.272 c
.279 5.184 .081 5.029 .004 4.895 c
-.074 4.764 -.339 4.38 -.373 4.277 c
-.406 4.172 -.576 3.938 -.472 3.523 c
-.367 3.107 -.333 3.019 y
-.321 2.901 -.262 2.936 v
-.2 2.968 -.146 3.102 -.097 3.156 c
-.047 3.212 .141 3.434 .19 3.477 c
.24 3.523 .389 3.665 .477 3.738 c
.566 3.811 .852 4.031 .907 4.071 c
.963 4.11 1.167 4.287 1.212 4.337 c
1.255 4.388 1.382 4.582 1.409 4.612 c
1.438 4.646 1.496 4.708 1.531 4.708 c
1.564 4.708 1.619 4.675 1.603 4.612 c
1.586 4.555 1.543 4.475 1.491 4.397 c
1.442 4.321 1.37 4.216 1.338 4.176 c
1.305 4.136 1.194 4.056 1.145 4.009 c
1.095 3.967 .88 3.827 .81 3.761 c
.736 3.695 .652 3.635 .512 3.502 c
.365 3.366 .312 3.323 .229 3.223 c
.147 3.125 0 2.885 -.041 2.792 c
-.08 2.696 -.135 2.498 -.135 2.427 c
-.135 2.353 -.097 2.031 -.063 1.883 c
-.03 1.732 -.03 1.599 .014 1.549 c
.059 1.501 .091 1.506 .118 1.527 c
.147 1.549 .168 1.645 .208 1.693 c
.246 1.743 .284 1.788 .322 1.833 c
.362 1.879 .5 1.993 .543 2.026 c
.587 2.059 .692 2.148 .746 2.187 c
.804 2.227 .958 2.387 1.013 2.42 c
1.067 2.455 1.15 2.514 1.188 2.52 c
1.229 2.524 1.319 2.547 1.343 2.542 c
1.366 2.538 1.426 2.504 1.388 2.458 c
1.349 2.414 1.217 2.298 1.188 2.275 c
1.161 2.254 1.007 2.122 .936 2.059 c
.862 1.999 .72 1.904 .665 1.86 c
.61 1.816 .517 1.727 .472 1.671 c
.429 1.615 .362 1.506 .328 1.424 c
.295 1.339 .246 1.114 .229 .99 c
.212 .867 .24 .724 .253 .687 c
.263 .646 .267 .609 .279 .575 c
.29 .543 .345 .452 .365 .569 c
.389 .687 .417 .874 .477 .946 c
.537 1.02 .715 1.25 .731 1.095 c
.746 .94 .556 .598 .569 .475 c
.587 .354 .551 .192 .482 .092 c
.417 -.007 .196 -.072 .158 -.067 c
.118 -.062 0 0 y
f
Q
q 1 0 0 1 578.21 27.082 cm 0 0 m
.164 .542 .176 .587 v
.188 .631 .131 .741 .121 .775 c
.109 .81 .054 .932 .054 .984 c
.054 1.042 .065 1.107 .109 1.13 c
.153 1.153 .176 1.175 .231 1.239 c
.285 1.308 .341 1.363 .351 1.462 c
.363 1.561 .351 1.596 .386 1.673 c
.418 1.75 .462 1.817 .551 1.872 c
.638 1.928 .693 1.993 .772 2.037 c
.849 2.081 .926 2.172 .98 2.228 c
1.036 2.282 1.148 2.393 1.213 2.427 c
1.279 2.461 1.345 2.482 1.411 2.491 c
1.476 2.505 1.521 2.516 1.599 2.537 c
1.676 2.56 1.753 2.659 1.775 2.692 c
1.797 2.726 1.786 2.825 1.664 2.78 c
1.543 2.735 1.366 2.692 1.313 2.682 c
1.256 2.669 1.114 2.637 1.07 2.592 c
1.025 2.549 .97 2.461 .849 2.383 c
.728 2.304 .65 2.206 .584 2.206 c
.517 2.206 .484 2.206 .508 2.315 c
.529 2.427 .54 2.592 .574 2.726 c
.606 2.857 .65 3.058 .672 3.157 c
.693 3.259 .737 3.445 .804 3.469 c
.87 3.489 .991 3.545 1.091 3.645 c
1.19 3.744 1.323 3.866 1.4 3.954 c
1.476 4.042 1.599 4.276 1.664 4.331 c
1.73 4.388 1.84 4.509 1.952 4.553 c
2.062 4.598 1.996 4.589 2.161 4.62 c
2.326 4.653 2.37 4.644 2.437 4.686 c
2.503 4.731 2.548 4.775 2.514 4.786 c
2.481 4.797 2.481 4.797 2.415 4.831 c
2.349 4.863 2.293 4.907 2.216 4.887 c
2.14 4.863 2.05 4.843 1.974 4.809 c
1.897 4.775 1.709 4.696 1.653 4.62 c
1.599 4.542 1.433 4.366 1.378 4.299 c
1.323 4.233 1.224 4.11 1.179 4.057 c
1.134 3.999 1.08 3.945 1.025 3.912 c
.97 3.878 .837 3.844 .87 3.978 c
.904 4.11 .915 4.255 .949 4.398 c
.98 4.542 1.014 4.809 1.091 4.887 c
1.168 4.965 1.289 5.098 1.345 5.151 c
1.4 5.206 1.476 5.328 1.378 5.317 c
1.279 5.307 1.224 5.417 1.235 5.496 c
1.245 5.574 1.279 5.827 1.313 5.938 c
1.345 6.05 1.423 6.248 1.456 6.315 c
1.488 6.381 1.5 6.436 1.588 6.525 c
1.676 6.615 1.808 6.647 1.719 6.727 c
1.631 6.803 1.313 6.959 1.411 6.925 c
1.51 6.892 1.4 6.77 1.389 6.727 c
1.378 6.682 1.323 6.626 1.289 6.525 c
1.256 6.427 1.19 6.283 1.168 6.183 c
1.148 6.082 1.058 5.807 1.047 5.672 c
1.036 5.539 .991 5.496 .991 5.45 c
.991 5.406 .915 5.328 .86 5.429 c
.804 5.528 .804 5.607 .782 5.695 c
.76 5.783 .772 5.871 .76 5.928 c
.75 5.982 .617 6.082 .617 5.938 c
.617 5.794 .606 5.761 .617 5.695 c
.627 5.628 .627 5.561 .638 5.474 c
.65 5.385 .716 5.131 .75 5.074 c
.782 5.019 .849 4.887 .826 4.775 c
.804 4.664 .75 4.589 .728 4.509 c
.704 4.434 .661 4.276 .508 4.441 c
.351 4.609 -.065 5.273 -.1 5.317 c
-.134 5.363 -.177 5.395 -.221 5.284 c
-.265 5.175 -.299 5.295 -.211 5.141 c
-.123 4.986 -.033 4.852 .021 4.731 c
.076 4.609 .176 4.498 .231 4.419 c
.285 4.344 .351 4.276 .407 4.188 c
.462 4.1 .484 4.089 .473 3.889 c
.462 3.689 .407 3.29 .351 2.914 c
.297 2.537 .231 2.206 .176 2.116 c
.121 2.027 .109 1.982 0 2.072 c
-.111 2.16 -.078 2.26 -.123 2.304 c
-.167 2.351 -.243 2.404 -.32 2.36 c
-.397 2.315 -.541 2.238 -.53 2.172 c
-.519 2.105 -.608 2.126 -.464 2.072 c
-.32 2.016 -.299 2.006 -.265 1.95 c
-.233 1.895 -.221 1.883 -.177 1.829 c
-.134 1.772 -.1 1.807 -.012 1.772 c
.076 1.739 .099 1.783 .131 1.693 c
.164 1.607 .241 1.65 .164 1.484 c
.087 1.318 -.055 1.283 -.111 1.153 c
-.167 1.02 -.155 .942 -.155 .842 c
-.155 .741 -.167 .676 -.221 .566 c
-.276 .453 -.199 .532 -.403 .343 c
-.608 .155 -.795 .044 -.815 -.057 c
-.838 -.154 -.905 -.2 -.838 -.243 c
-.772 -.288 -.739 -.255 -.696 -.345 c
-.649 -.433 -.597 -.441 -.597 -.531 c
-.597 -.619 -.331 -.401 y
0 0 l
f
Q
EMC
EMC
endstream
endobj
57 0 obj
<>stream
hn0{i
hDU\ٵAz#j`J)Rgxė-P "Kv<(,nH[
\4 Y}fAb \pV`c~x1GXjsb 3 @l{r}r/Q!0\WP6*I\(ht[T6ӯ+#;J<ʖ(4$og0é-L:Jׁ7"1:1zJJ0Tx0J
vFh
Jk89rW<.3UA7E!Ӿ
HYִ@1FC_[];gwfdM 2A& 係aʍϵ0 o
endstream
endobj
58 0 obj
<>stream
Adobe Illustrator CS4
2020-04-30T06:52:19+05:30
136
256
JPEG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282.222222
211.666667
Millimeters
1
False
False
Cyan
Magenta
Yellow
Black
Default Swatch Group
0
application/postscript
endstream
endobj
60 0 obj
<>stream
/GS1 gs
BT
/F5 1 Tf
10.959 0 0 10.959 59.7543 697.8896 Tm
0 0 0 rg
0 Tc
0 Tw
[(was)-586.1(amplied)-578.8(using)-583.3(a)-582.1(One-Step)-584.3(PCR)-583.9(Kit)-577.5(\(Primer)]TJ
0 -1.1847 TD
[(Design\))-712(in)-714.7(a)-711.4(real-time)-708.6(thermocycler)-709.4(\(Rotor-Gene)]TJ
0 -1.1795 TD
[(6000,)-395.7(Corbett)-389.9(Robotics\).)-390.6(Custom-made)-390.7(primers)-397.1(were)]TJ
0 -1.1847 TD
[(directed)-396.9(against)-398.1(human)-392.3(Shh,)-393.7(Patched1,)-397.3(and)-395.4(Smooth-)]TJ
0 -1.1795 TD
[(ened)-341.8(\(Primer)-339.9(Design;)-340.4(Table)-343.7(1\).)-341.2(Fluorescent)-336.6(data)-342.2(were)]TJ
0 -1.1847 TD
[(collected)-342.2(at)-342.2(least)-336.5(once)-341.1(during)-342.6(each)-341.7(cycle)-340.9(of)-341.9(amplica-)]TJ
0 -1.1795 TD
[(tion,)-460.4(which)-451(allowed)-457.4(for)-453.9(real-time)-455.2(monitoring)-454.2(of)-455.7(the)]TJ
T*
[(amplication.)-667(Data)-666.1(were)-661.9(automatically)-666.5(normalized)]TJ
0 -1.1847 TD
[(and)-348.8(a)-344.1(threshold)-345.1(was)-348.1(set)-345.8(at)-347.4(the)-344.3(level)-346.5(where)-343(the)-344.3(rate)-348.5(of)]TJ
0 -1.1795 TD
[(amplication)-367.7(was)-368.8(the)-365(greatest)-365.7(during)-368.5(the)-370.2(exponential)]TJ
0 -1.1847 TD
[(phase.)-483.4(Ct-values)-479.9(were)-480.8(collected,)-476(and)-483.3(analyzed)-477.3(using)]TJ
0 -1.1795 TD
[(the)-323.7(comparative)-318.5(Ct)-319.8(\(2[-Delta)-320(Delta)-318.1(C\(t\)],)-324.7(or)-320.7(2-DDCt\))]TJ
0 -1.1847 TD
[(method)-276.4(where)-280.9(the)-277.1(comparative)-277.1(expression)-277.4(level)-274.1(equals)]TJ
0 -1.1795 TD
-.0153 Tc
[(t)-3(o)-265.4(2-DDCt.)-268.1(The)-266.6(e)-2.8(xpress)-3.1(ion)-265.8(o)-1.6(f)-267.5(m)0(ess)-3.1(e)2.4(nger)-266.9(RNA)-269.8(\()1.8(mRNA\))]TJ
0 -1.1847 TD
0 Tc
[(was)-327.5(normalized)-326.1(to)-325.8(a)-323.5(housekeeping)-326.8(gene)-326.2(\()]TJ
/F12 1 Tf
16.7921 0 TD
(b)Tj
/F5 1 Tf
.5535 0 TD
[(-actin\))-321.6(and)]TJ
-17.3456 -1.1795 TD
[(expressed)-378.5(as)-378.5(a)-375.2(ratio.)-376.3(Prism)-374.6(Software)-373.2(\(Graphpad\))-377.8(was)]TJ
T*
[(used)-301(for)-298.7(data)-300.9(analysis.)]TJ
/F6 1 Tf
10.4607 0 0 10.4607 59.7543 457.0581 Tm
/Cs8 cs 1 scn
[(The)-301.7(CCI)-301.6(injury)-299.2(and)-298.4(drug)-299.2(treatment)]TJ
/F5 1 Tf
10.959 0 0 10.959 59.7543 444.0755 Tm
0 0 0 rg
[(C57Bl/6)-259.5(mice)-263.6(\(2025)-164.2(g,)-260.4(78)-265(weeks)-260.8(old\))-259.7(were)-258.4(housed)-263.3(in)]TJ
T*
[(a)-256.2(12-h)-257.3(light/dark)-252.1(cycle)-258.1(with)-252.7(food)-253.1(and)-255.7(water)]TJ
/F10 1 Tf
17.4853 0 TD
[(ad)-257.7(libitum)]TJ
/F5 1 Tf
4.1178 0 TD
(.)Tj
-21.6032 -1.1847 TD
[(All)-344.3(animal)-346.2(procedures)-349(followed)-341.4(guidelines)-345.7(established)]TJ
0 -1.1795 TD
[(by)-361.2(the)-354.7(National)-357(Institutes)-357(of)-357.5(Health)-356.2(\(NIH\))-358.3(Guide)-359.2(for)]TJ
0 -1.1847 TD
[(the)-566.8(Care)-563.6(and)-566.1(Use)-565.5(of)-564.4(Laboratory)-563(Animals,)-564.4(Animal)]TJ
0 -1.1795 TD
[(Research:)-1097.2(Reporting)-1089.6(of)-1092(In)-1091.8(Vivo)-1095.8(Experiment)5.1(s)]TJ
0 -1.1847 TD
[(\(ARRIVE\),)-208.7(and)-209.2(were)-206.6(approved)-207(by)-206(the)-204.7(University)-203.9(of)-207.4(Mi-)]TJ
0 -1.1795 TD
[(amis)-355.9(Institutional)-349.2(Animal)-349.7(Care)-351.5(and)-354(Use)-353.4(Committees)]TJ
T*
[(\(Protocol)-298.1(Number)-301.3(14-157\).)]TJ
1.0036 -1.1847 TD
-.0179 Tc
[(The)-269.2(s)-.5(tatistical)-274.9()44.9()3.5(power)44.9()-270.7(m)2.6(ethods)-274.7(w)2.1(ere)-269.2(u)-4.9(s)4.7(e)-.2(d)-273.9(t)-.4(o)-268(a).1(rrive)-274.4(at)]TJ
-1.0036 -1.1795 TD
.2559 Tc
[(t)273.4(h)274.8(ea)273.9(p)274.1(p)274.1(r)273.3(o)274.8(p)274.1(r)273.3(i)272.8(a)273.9(t)273.4(es)273.3(a)273.9(m)276.4(p)274.1(l)273.1(es)278.5(i)272.8(z)273.6(ew)275.9(i)272.8(t)273.4(hap)274.1(o)274.8(w)275.9(e)273.6(ro)274.8(f0)274.5(.)272.1(9).3(a)273.9(t)-.8(a0)274.5(.)277.3(0)274.5(5)]TJ
0 -1.1847 TD
-.0181 Tc
[(alpha.)-203.6(A)-195(m)-2.8(inimum)-199.3(of)-197.9(10)-201.3(animals)-197.3(w)1.9(ere)-202.2(u).1(sed)-196.5(i)-1.2(n)-201.3(e)-.4(ach)-195.8(g).2(roup)]TJ
0 -1.1795 TD
[(for)-186.9(t)-.6(he)-186.7(behavioral)-187.1(analysis)-186.9(and)-186.1(a)-186.4(minimum)-183.8(o).8(f)-187.5(5)-185.7(animals)-186.9(i)3.9(n)]TJ
0 -1.1847 TD
[(each)-288.9(group)-289.6(f)-1.3(or)-285.2(the)-290.1(h).8(istological)-285.4(a)-.1(nalysis.)-286.4(Mice)-290.1(were)-285(anes-)]TJ
0 -1.1795 TD
[(thetized)-962.1(with)-966.6(ketamine)-962.6(\(75)-165.1(m)-2.8(g/kg\))-963.2(a)-.1(nd)-967.3(xylazine)]TJ
0 -1.1847 TD
[(\(14)-170.2(m)2.4(g/kg\))-456.2(b).8(y)-455.1(i)-1.2(ntraperitoneal)-456.1(injection)-454.8(a)-.1(nd)-460.3(positioned)]TJ
0 -1.1795 TD
[(in)-289.3(a)-284.7(s)-.7(tereotaxic)-290.1(frame.)-286.4(Body)-284.3(temperature)-290.1(w)1.9(as)-285.2(monitored)]TJ
0 -1.1847 TD
-.0179 Tc
[(and)-615.3(m)2.6(aintained)-610.1(a).1(t)-616(3).7(7)]TJ
/F8 1 Tf
9.2548 0 TD
0 Tc
()Tj
/F5 1 Tf
.3776 0 TD
-.0186 Tc
[(C.)-612.8(A)-614.5(5)0(-mm)-613.7(c)-.9(raniotomy)-610.8(w)1.4(as)]TJ
-9.6324 -1.1795 TD
-.018 Tc
[(made)-367.6(over)-367.9(the)-367.6(r)-.6(ight)-367.8(parieto-temporal)-368.1(cortex)-367.4(\()]TJ
/F11 1 Tf
18.1578 0 TD
0 Tc
()Tj
/F5 1 Tf
.7708 0 TD
-.02 Tc
[(2.5)-172.1(m).5(m)]TJ
-18.9286 -1.1795 TD
-.0182 Tc
[(caudal)-513.1(a)-.2(nd)-517.3(2.0)-170.3(m)2.3(m)-515(l)4.2(ateral)-513.1(from)-509.8(bregma\).)-514.1(The)-512.7(i)3.8(njury)]TJ
0 -1.1847 TD
-.0179 Tc
[(was)-388.5(g).4(ene)4.9(r)-.5(ated)-392.9(using)-392.8(a)-393.1(3-mm)-390.6(beve)4.9(led)-392.9(t)-.4(ip)-392.9(attac)4.9(h)-4.2(ed)-392.9(to)-392.2(a)]TJ
22.912 46.7965 TD
-.0182 Tc
[(CCI)-280.1(device)-279.9(\(Custom)-277(D)2.1(esign)-273.9(&)-277.6(Fabrication\),)-281.3(a)-.2(t)-274.9(a)-274.4(velocity)]TJ
0 -1.1847 TD
-.0185 Tc
[(of)-281(6.0)-165.5(m)-3.2(/sec,)-286.8(a)-279.9(d)-.3(epth)-284.2(of)-286.2(0.5)-170.6(mm,)-286.8(and)-284.8(a)-.5(n)-279.3(i)-1.6(mpact)-280.4(duration)]TJ
0 -1.1795 TD
-.0183 Tc
[(of)-280.8(150)-170.4(msec.)-281.4(Sham)-282.3(mice)-285.2(received)-284.6(c)-.6(raniotomy)-284.5(o).6(nly.)-281.4(After)]TJ
0 -1.1847 TD
-.0195 Tc
[(CCI)-338.3(in)-6.2(jur)-2.1(y)-337.5(t)-2(h)-.6(e)-332.9(s)-2.1(ki)-2.6(n)-337.2(w).5(as)-338.4(s)-2.1(u)-1.3(tu)-6.5(red.)-339.5(St)-2(ar)-2.1(ti)-2.6(ng)-337.5(on)-337.2(t)-2(h)-.6(e)-332.9(d)-1.3(ay)-337.5(of)]TJ
0 -1.1795 TD
-.0182 Tc
[(injury,)-462.4(m)2.3(ice)-460.9(r)-.8(eceived)-455.2(t)-.7(he)-460.9(following:)-457.2(1)-460()-462.7(c)-.5(yclopamine)]TJ
0 -1.1847 TD
[(tre)4.6(a)-.2(ted)-605.3(a)-.2(nimals)-606.1(received)-605.3(i)-1.3(ntra-peritoneal)-606.3(i)-1.3(njection)-605(o).7(f)]TJ
0 -1.1795 TD
-.018 Tc
[(cyclopamine)-781.5(\()-.9(10)-165(mg/kg,)-782.9(Sigma)-781.2(A)1.7(ldrich\))-782.1(d).2(iluted)-786.1(in)]TJ
T*
-.0182 Tc
[(hydroxypropyl)-363.1(b).7(eta)-357.2(c)-.5(yclodextrin)-361.8(\()-1.1(HBC;)-364.1(Sigma)-362.4(A)1.5(ldrich\))]TJ
0 -1.1847 TD
[(once)-512.6(a)-507.1(d)-5.1(ay)-506.8(for)-512.8(5)-511.7(days;)-508.8(2)-511.7(-)-512.5(c)-.4(ontrol)-507.9(animals)-512.9(r)-.7(eceived)]TJ
0 -1.1795 TD
-.0179 Tc
[(intr)4.7(a-peritoneal)-331.8(injec)4.9(t)-.4(ion)-330.5(o)1(f)-332.2(H)-2.8(BC)-329.3(only)-330.7(once)-331.3(a)-331(d)-4.9(ay)-330.7(f)4.1(o)-4.2(r)-331.6(5)]TJ
0 -1.1847 TD
[(days;)-249.9(3)-252.7(SAG)-251.3(t)-.3(re)5(ated)-253.1(animals)-253.9(r)-.4(eceived)-253.1(o)1.1(ral)-248.9(a).2(dministration)]TJ
0 -1.1795 TD
-.0181 Tc
[(of)-389.3(SAG)-386.1(\()-1(Calbiochem;)-389.8(0).5(.15)-170.2(m)2.4(g)-387.8(i)-1.2(n)-387.6(0).5(.5%)-385.5(m)-2.8(ethylc)4.7(ellulose/)]TJ
0 -1.1847 TD
-.0183 Tc
[(0.2%)-277.1(Tween)-279.1(80/10)-165.3(g)-279.4(body)-284.5(w)1.7(eight\))-280.6(once)-280(a)-279.7(d)-5.3(ay)-284.5(for)-280.3(5)-279.1(days.)]TJ
/F6 1 Tf
10.4607 0 0 10.4607 310.8472 516.529 Tm
/Cs8 cs 1 scn
0 Tc
(Behavior)Tj
/F5 1 Tf
10.959 0 0 10.959 310.8472 503.603 Tm
0 0 0 rg
[(Motor)-315(function)-322.7(was)-317.1(tested)-323.5(using)-319.5(the)-318.5(rotarod)-318.7(test.)-322.4(The)]TJ
T*
[(rotating)-219.3(cylindrical)-220.1(rod)-219.7(was)-218.8(50-mm)-219.7(wide)-222.2(and)-219.5(had)-224.3(a)-220(lin-)]TJ
0 -1.1795 TD
[(ear)-210.8(acceleration)-211.3(from)-205.7(10)-169.8(rpm)-207.7(to)-211.9(60)-164.6(rpm)-207.7(over)-212.3(a)-209.6(period)-208.4(of)]TJ
0 -1.1847 TD
[(10)-164.6(min)-264.9(\(i.e.,)-267(rate)-260.6(of)-264.3(acceleration)-263(was)-265.4(5)-167.7(rpm\).)-262.4(Mice)-263(were)]TJ
0 -1.1795 TD
[(pre-trained)-337.8(daily)-335.7(for)-340.1(1)-333.2(week)-340.3(prior)-335.5(to)-336.1(the)-339.2(injury.)-337.7(After)]TJ
T*
[(injury)-271.2(on)-267.8(days)-269.6(3,)-270.4(7,)-270.4(and)-271.2(14,)-272.5(mice)-268.8(were)-273.9(given)-267.4(four)-270.1(trials)]TJ
0 -1.1847 TD
[(each)-290(day)-292.2(and)-291.9(the)-292.6(time)-294.8(to)-289.5(fall)-292.9(off)-294.1(the)-287.4(rotarod)-292.8(was)-291.2(aver-)]TJ
0 -1.1795 TD
[(aged)-300.4(over)-300.3(the)-297.8(four)-301.2(trials.)]TJ
/F6 1 Tf
10.4607 0 0 10.4607 310.8472 387.0424 Tm
/Cs8 cs 1 scn
[(Immunohistoche)5.3(mistry)-303.4(of)-300.7(free-oating)-298.7(sections)]TJ
/F5 1 Tf
10.959 0 0 10.959 310.8472 374.0597 Tm
0 0 0 rg
[(Mice)-216.4(were)-217(anesthetized)-221.2(using)-221.2(ketamine)-217.3(and)-219.5(xylazine)-214.9(by)]TJ
T*
[(intraperitoneal)-525.5(injection)-528.4(and)-529.9(transcardially)-528.5(perfused)]TJ
0 -1.1847 TD
[(with)-278.6(phosphate-buffered)-282.4(saline)-282.4(\(PBS\))-287.6(and)-281.6(4%)-281.6(parafor-)]TJ
0 -1.1795 TD
[(maldehyde)-316.6(\(pH)-317(7.4\).)-316.8(Animals)-316.8(were)-315.3(sacriced)-321.5(at)-316.3(7,)-316.9(14,)]TJ
0 -1.1847 TD
[(and)-442(28)-443.9(days)-445.5(after)-445.5(injury.)-441.2(The)-446.2(brains)-441.4(were)-444.6(stored)-441.4(in)]TJ
0 -1.1795 TD
[(4%)-690.3(paraformaldehyde)-693.8(overnight,)-690.7(30%)-692.4(sucrose)-692.8(for)]TJ
0 -1.1847 TD
[(48)-164.6(h,)-301.2(and)-297.1(then)-300(transferred)-297.6(into)-300.7(PBS)-301.1(with)-294.1(0.5%)-298.5(sodium)]TJ
0 -1.1795 TD
[(azide.)-221.3(The)-223.8(brains)-224.1(were)-227.3(then)-222.4(sliced)-220.9(coronally)-226(around)-221.9(the)]TJ
T*
[(injury)-338.5(site)-339.3(using)-335(a)-339(cryostat)-338.6(into)-337(40-)]TJ
/F12 1 Tf
14.3969 0 TD
(l)Tj
/F5 1 Tf
.5535 0 TD
[(m)-336.4(thick)-340.3(sections.)]TJ
-14.9505 -1.1847 TD
[(Serial)-526.1(free-oating)-525.7(sections)-525.5(were)-522.2(collected)-528.4(in)-523.3(a)-530.4(12-)]TJ
0 -1.1795 TD
[(well)-300.4(plate.)-298.8(There)-302.5(were)-299.8(approximat)5.5(ely)-303.8(four)-301.2(to)-299.9(ve)-297(free-)]TJ
0 -1.1847 TD
[(oating)-349.1(sections)-354.8(that)-352.4(traversed)-352.7(the)-354.7(injury)-354(site)-354.8(in)-352.6(each)]TJ
0 -1.1795 TD
[(well.)-242.8(The)-244.5(sections)-241(were)-242.8(kept)-244(in)-244(a)-245.9(PBS)-239(and)-245.4(0.5%)-241.6(sodium)]TJ
0 -1.1847 TD
[(azide)-299.6(solution)-296.3(at)-300.8(4)]TJ
/F8 1 Tf
7.4028 0 TD
()Tj
/F5 1 Tf
.3932 0 TD
(C.)Tj
-6.7975 -1.1795 TD
[(Ed)21.5(U)-450.5(d)0(e)15.2(t)12.3(e)12.5(c)0(t)19.6(i)0(o)20.2(n)-452.3(wa)17.3(s)-448.2(p)0(e)20.3(r)0(f)18.7(o)0(r)20.8(m)10.2(ed)-445.2(u)13(s)0(i)18.7(n)0(g)-439.2(t)0(h)20.8(e)-453.1(Cl)21.4(ic)19(k-)20.5(iT)]TJ
/F8 1 Tf
8.2191 0 0 7.3052 543.4014 197.6315 Tm
()Tj
/F5 1 Tf
10.959 0 0 10.959 310.8472 179.7732 Tm
[(E)13.6(d)0(U)-277.1(A)14.5(le)19.3(xa)-274.5(Fl)19.9(uo)21.6(r)]TJ
/F8 1 Tf
8.2191 0 0 7.3052 384.0377 184.6488 Tm
()Tj
/F5 1 Tf
10.959 0 0 10.959 393.6188 179.7732 Tm
[(59)21.7(4)-286.6(I)12.3(m)10.2(a)12.8(gi)19.6(ng)-273.6(Ki)20.7(t)-282.6(f)0(o)20.2(l)0(l)18.9(o)0(w)23.4(i)0(n)19.8(g)-286.9(t)12.3(h)0(e)-273.9(m)10.2(a)12.8(n)0(-)]TJ
-7.5528 -1.1795 TD
[(u)13(f)0(a)19.3(c)0(t)19.6(u)0(r)20.1(e)0(r)19.5()0(s)-421.6(i)11.7(ns)20.4(tr)19.4(uc)20.3(ti)18.8(on)21.9(s)-432.7(\()11.9(C1)17.6(0)13.4(3)0(9)21.7(9)0(,)-420.4(I)0(n)20.4(v)0(i)19.6(t)0(r)19.3(o)0(g)21.6(e)0(n)20.6(\))0(.)-421.9(S)0(e)20.1(c)0(t)19.6(i)0(o)20.2(n)0(s)]TJ
T*
[(we)22.1(re)-477.1(s)12.2(u)0(b)16.4(s)12.2(eq)20.7(ue)20.3(nt)20.5(ly)-476.7(la)19.7(be)21(le)19.4(d)-488.8(w)14.8(it)18.8(h)-488.1(e)12.5(it)18.8(he)21(r)-489.6(G)14.8(FA)17.2(P)-488.1(\()11.9(r)12.2(a)0(b)16.2(b)13.7(i)11.7(t)0(,)]TJ
0 -1.1847 TD
[(Da)22.7(ko)21.6(\),)-478.8(n)13.3(e)0(s)19.5(t)0(i)18.8(n)-483.3(\(m)16.9(o)13.7(u)0(s)20.1(e)0(,)-478.2(V)0(e)21.5(c)0(t)19.6(o)0(r)20.8(L)0(a)21.3(b)0(s)20.8(\))0(,)-478.8(o)13.7(r)-489.6(D)15.1(CX)-478.6(\()11.9(g)0(u)21(i)0(n)19.8(e)0(a)]TJ
0 -1.1795 TD
[(p)13(i)0(g)19.6(,)-526.9(M)10.7(i)0(l)18.5(l)12(ip)19.5(or)20.8(e\))-518.8(pr)20.1(e-)19.9(di)19.5(lu)19.9(te)19.6(d)-530.2(i)11.7(n)-524.7(0)0(.)19.3(3)0(%)-519.5(T)13.9(ri)18.7(t)12.3(o)0(n)-516.1(X)0(-)16.1(1)13.4(00)-516.4(in)]TJ
0 -1.1847 TD
[(P)13.6(B)0(S)-288.9(w)0(i)21.3(t)12.3(h)-296.7(5)0(%)-286.7(d)0(o)21.6(n)0(k)16.1(e)12.5(y)-297.3(s)12.2(er)19.5(um)18(,)-299.3(w)14.8(it)18.8(h)-296.7(o)0(v)21.6(e)0(r)19.5(n)0(i)19.8(g)0(h)21.6(t)-298.1(i)11.7(n)0(c)20.6(u)0(b)16.4(a)12.8(ti)18.8(on)]TJ
0 -1.1795 TD
-.0128 Tc
[(at)-564.4(4)]TJ
/F8 1 Tf
1.7485 0 TD
0 Tc
()Tj
/F5 1 Tf
.3828 0 TD
[(C.)-538.3(Fl)19.9(uo)16.4(r)12.2(e)0(s)19.5(c)0(e)19.8(n)0(t)-538.2(s)0(e)19.5(c)0(o)15.9(n)13.3(da)20.7(ry)-543.7(a)12.8(n)0(t)20.5(i)0(b)20.2(o)0(d)21.6(i)0(e)19(s)-551.7(\()11.9(A)0(l)16.2(e)12.5(xa)20.4(48)21.6(8,)]TJ
-2.1313 -1.1847 TD
[(M)10.7(o)13.7(le)19.4(cu)20.3(la)19.7(r)-246.4(P)0(r)15.5(o)13.7(be)21(s\))-239.7(we)22.1(re)-239.1(i)11.7(n)0(c)15.5(u)13(ba)21.3(te)19.6(d)-250.8(f)11.7(or)-237.9(2)-157.3(h)-245(be)21(fo)20.2(re)-239.1(f)11.7(u)0(r)20.1(t)0(h)20.8(e)0(r)]TJ
0 -1.1795 TD
[(wa)22.5(sh)20.7(es)19.5(.)-356.2(N)0(u)22.6(c)0(l)19.3(e)0(i)-348.3(w)14.8(er)19.5(e)-354.8(l)0(a)19.7(b)0(e)21(l)0(e)19.3(d)-354.3(wi)21.3(th)-346.5(Ho)23.6(ec)14.6(h)13.7(s)0(t)-342.8(3)0(3)16.5(3)13.4(42)-345.6(s)12.2(o)0(l)20.6(u)0(-)]TJ
0 -1.1847 TD
[(t)12.3(i)0(o)20.2(n)-260.8(\(d)19.8(il)18.5(ut)20.1(ed)-253.8(PB)22.4(S\))-254.7(be)21(fo)20.2(re)-254.6(m)10.2(o)13.7(un)16(t)12.3(i)11.7(ng)-252.9(in)-254.3(M)10.7(o)13.7(wi)16.2(o)13.7(l)-262.1(\(H)16.6(a)12.8(r)0(c)19.5(o)0(\))20.5(.)]TJ
ET
59.754 154.375 239.131 .22682 re
f
59.754 101.934 239.131 .28342 re
f
59.754 136.687 239.131 .22678 re
f
BT
/F4 1 Tf
8.9663 0 0 8.9663 59.7543 161.0078 Tm
[(Table)-306.5(1.)-500.5(PCR)-300.6(Primer)-303(Sequences)]TJ
/F9 1 Tf
7.9702 0 0 7.9702 59.7543 142.8661 Tm
[(Gene)-3646.8(Forward)-328(primer)-7525.4(Reverse)-326.7(primer)]TJ
/F6 1 Tf
0 -2.1197 TD
[(Shh)-1394.5(GAAGAG)12.6(GAGGCACCCCAA)12.5(AA)-861.9(CCTTAAATCG)13.5(CTCGGAGTTTC)8.3(TG)]TJ
0 -1.1239 TD
[(Smo)-1124.5(ACCACC)10.5(TACCAGCCTC)7.6(TCTC)-1712(CCCACAAAAC)11.6(AAATCCCA)11.7(CTCA)]TJ
0 -1.131 TD
[(Ptc)-1687.5(GTCGCACAG)13.1(AACTCCACTC)9.3(A)-1423.2(GTCAGAGAA)13.1(GGATTTCAGG)8.4(ATGTC)]TJ
1.131 -2.2406 TD
[(Primer)-492.4(sequences)-494.7(for)-496.3(RT-qPCR)-493.8(in)-499.4(human)-492.9(neural)-499.7(tissue.)-493.9(Beta-actin)]TJ
-1.131 -1.1239 TD
[(primers)-294(were)-296.3(obtained)-293.3(from)-296.3(Primer)-293.2(Design)-295.6(\(HK-SY-HU-60)12.5(0,)-303.1(ACTB\).)]TJ
1.131 -1.1239 TD
[(PCR,)-352.7(polymeras)11.3(e)-360.7(chain)-351.5(reaction;)-351.7(Ptc,)-359.5(Patched;)-350.7(Shh,)-351.1(sonic)-354.1(hedgehog;)]TJ
-1.131 -1.131 TD
[(Smo,)-301.6(Smoothen)12.3(ed.)]TJ
/F7 1 Tf
0 86.8229 TD
[(Pringle)-298.4(et)-300.9(al.;)-297.1(Neurotraum)10.4(a)-305.1(Reports)]TJ
/F6 1 Tf
14.5464 0 TD
[(2021,)-295.3(2.1)]TJ
-14.5464 -1.2021 TD
[(http://online)10(.liebertpub.com)7(/doi/10.10)9.8(89/neur.2020.)11.5(0016)]TJ
60.483 1.2021 TD
(29)Tj
ET
/EmbeddedDocument /MC9 BDC
/Document /MC10 BDC
q
1 i
572.031 35.263 10.035 -19.162 re
W n
1 .64 .53 .47 k
q 1 0 0 1 572.031 16.06 cm 0 0 m
.966 3.153 1.461 4.22 v
1.739 4.818 2.425 6.378 3.087 7.332 c
3.497 7.924 4.368 8.916 4.541 9.195 c
4.633 9.338 4.701 9.556 y
4.901 9.641 5.09 9.748 v
5.279 9.855 5.638 10.053 5.702 10.239 c
5.807 10.549 5.997 10.624 y
6.187 10.665 6.271 10.678 v
6.44 10.699 6.566 10.772 6.735 10.858 c
6.904 10.945 7.12 11.061 7.516 11.253 c
7.799 11.391 10.08 12.245 y
10.048 12.161 9.858 12.011 v
9.667 11.862 9.25 11.707 9.083 11.621 c
8.914 11.536 7.475 10.816 7.199 10.645 c
6.926 10.474 6.091 9.925 5.47 9.365 c
5.02 8.959 4.51 8.356 4.184 7.914 c
3.263 6.665 2.748 5.394 y
3.551 5.415 3.613 5.415 v
3.676 5.415 3.845 4.924 y
3.212 5.01 2.938 4.861 v
2.663 4.712 2.592 4.659 2.358 4.273 c
2.129 3.895 1.618 2.108 1.314 1.137 c
1.22 .833 1.125 .399 .936 .305 c
.813 .243 0 0 y
f
Q
Q
1 .64 .53 .47 K
1 J 0 j .405 w 4 M []0 d
/GS2 gs
1 i
q 1 0 0 1 577.63 22.437 cm 0 0 m
.403 .006 .637 -.007 v
.776 -.013 .996 -.05 1.152 -.097 c
1.288 -.142 1.451 -.222 1.542 -.287 c
1.659 -.373 1.711 -.47 1.783 -.568 c
1.832 -.637 1.991 -1.045 2.063 -1.095 c
2.136 -1.142 2.146 -1.179 2.081 -1.223 c
2.03 -1.257 2.004 -1.324 1.984 -1.373 c
1.965 -1.424 1.89 -1.613 1.84 -1.767 c
1.802 -1.888 1.742 -1.958 1.704 -2.004 c
1.646 -2.071 1.529 -2.169 1.405 -2.236 c
1.312 -2.285 1.146 -2.357 .995 -2.389 c
.716 -2.45 .292 -2.479 .174 -2.469 c
S
Q
1 .64 .53 .47 k
q 1 0 0 1 576.761 19.775 cm 0 0 m
-.054 0 -.095 .02 -.095 .045 c
-.095 .068 -.054 .088 0 .088 c
.05 .088 .094 .068 .094 .045 c
.094 .02 .05 0 0 0 c
-.35 .372 m
-.35 .416 -.271 .451 -.175 .451 c
-.08 .451 0 .416 0 .372 c
0 .328 -.08 .292 -.175 .292 c
-.271 .292 -.35 .328 -.35 .372 c
-.46 .766 m
-.46 .826 -.36 .874 -.238 .874 c
-.116 .874 -.018 .826 -.018 .766 c
-.018 .705 -.116 .656 -.238 .656 c
-.36 .656 -.46 .705 -.46 .766 c
-.586 1.181 m
-.586 1.262 -.477 1.325 -.34 1.325 c
-.206 1.325 -.095 1.262 -.095 1.181 c
-.095 1.101 -.206 1.035 -.34 1.035 c
-.477 1.035 -.586 1.101 -.586 1.181 c
-.19 1.641 m
-.19 1.586 -.269 1.545 -.364 1.545 c
-.462 1.545 -.539 1.586 -.539 1.641 c
-.539 1.69 -.462 1.732 -.364 1.732 c
-.269 1.732 -.19 1.69 -.19 1.641 c
-.373 2.112 m
-.265 2.112 -.175 2.066 -.175 2.012 c
-.175 1.954 -.265 1.908 -.373 1.908 c
-.481 1.908 -.569 1.954 -.569 2.012 c
-.569 2.066 -.481 2.112 -.373 2.112 c
-.303 2.491 m
-.215 2.491 -.143 2.459 -.143 2.418 c
-.143 2.379 -.215 2.347 -.303 2.347 c
-.39 2.347 -.46 2.379 -.46 2.418 c
-.46 2.459 -.39 2.491 -.303 2.491 c
-.175 2.753 m
-.131 2.753 -.095 2.735 -.095 2.708 c
-.095 2.688 -.131 2.666 -.175 2.666 c
-.22 2.666 -.255 2.688 -.255 2.708 c
-.255 2.735 -.22 2.753 -.175 2.753 c
1.513 .335 m
1.371 .352 1.288 .352 1.196 .352 c
1.101 .352 1.021 .346 .69 .352 c
.478 .354 .535 .471 .729 .496 c
.809 .506 .849 .51 .896 .518 c
.944 .525 .991 .531 1.212 .576 c
1.433 .62 1.308 .699 1.138 .711 c
1.009 .719 .952 .722 .903 .722 c
.824 .722 .78 .724 .569 .738 c
.3 .763 .425 .881 .548 .904 c
.611 .914 .637 .918 .675 .926 c
.715 .935 .738 .941 .984 .977 c
1.229 1.013 1.118 1.098 .976 1.109 c
.833 1.126 .809 1.13 .741 1.134 c
.68 1.137 .642 1.136 .471 1.158 c
.312 1.181 .375 1.266 .461 1.285 c
.547 1.307 .606 1.32 .661 1.321 c
.694 1.324 .723 1.33 .889 1.355 c
1.113 1.388 1.118 1.479 .868 1.512 c
.743 1.529 .723 1.53 .698 1.533 c
.661 1.54 .64 1.545 .44 1.566 c
.251 1.588 .304 1.698 .471 1.72 c
.589 1.734 .658 1.743 .69 1.749 c
.723 1.752 .77 1.752 .929 1.77 c
1.143 1.795 1.156 1.898 .936 1.918 c
.809 1.933 .797 1.93 .745 1.934 c
.715 1.937 .705 1.933 .485 1.953 c
.286 1.97 .358 2.07 .494 2.092 c
.62 2.112 .71 2.128 .802 2.142 c
.833 2.146 .858 2.14 1.131 2.2 c
1.284 2.232 1.25 2.307 1.068 2.315 c
1.002 2.32 .884 2.331 .793 2.339 c
.715 2.347 .666 2.347 .517 2.359 c
.366 2.373 .494 2.484 .548 2.498 c
.604 2.514 .84 2.535 .965 2.543 c
1.094 2.55 1.284 2.556 1.394 2.586 c
1.492 2.614 1.433 2.673 1.338 2.695 c
1.29 2.705 1.261 2.713 1.182 2.728 c
1.101 2.742 1.046 2.745 .965 2.761 c
.872 2.78 .889 2.769 .849 2.789 c
.809 2.814 .759 2.898 y
.729 2.985 .683 2.985 v
.636 2.985 .563 2.987 .421 2.987 c
.28 2.987 .326 2.994 .265 2.994 c
.2 2.994 .112 3.01 .026 3.016 c
-.061 3.024 -.171 3.03 -.227 3.024 c
-.281 3.016 -.358 2.992 -.417 2.959 c
-.504 2.906 -.622 2.777 -.692 2.695 c
-.764 2.614 -.875 2.397 -.915 2.323 c
-.954 2.251 -1.08 1.887 -1.129 1.808 c
-1.175 1.727 -1.302 1.675 y
-1.511 1.573 -1.387 1.54 v
-.964 1.423 -1.325 1.269 y
-1.31 1.172 l
-1.27 1.172 -1.262 1.153 v
-1.254 1.13 -1.129 1.158 -1.024 .874 c
-.977 .742 -.933 .651 -.85 .468 c
-.811 .38 -.677 .053 -.446 -.092 c
-.195 -.252 .012 -.207 .121 -.194 c
.251 -.181 .471 -.128 .581 -.125 c
.723 -.114 .763 -.114 .88 -.107 c
.999 -.099 1.361 -.092 y
.873 0 .778 0 v
.683 0 1.007 .094 1.142 .116 c
1.261 .139 1.378 .168 y
1.418 .184 1.553 .211 v
1.688 .242 1.655 .321 1.513 .335 c
f
Q
0 J
q 1 0 0 1 576.744 25.907 cm 0 0 m
-.066 -.119 -.079 -.096 v
-.122 .003 -.244 .254 -.395 .343 c
-.586 .454 -1.661 .89 -1.821 .965 c
-1.948 1.026 -2.464 1.133 -2.75 1.614 c
-3.04 2.104 -3.099 2.207 -3.229 2.355 c
-3.403 2.553 -3.277 2.712 -3.07 2.738 c
-2.962 2.752 -2.821 2.753 -2.718 2.753 c
-2.656 2.754 -2.654 2.877 -2.658 3.009 c
-2.668 3.222 -2.723 3.28 -2.881 3.41 c
-3.04 3.536 -3.323 3.744 -3.387 3.921 c
-3.451 4.096 -3.373 4.398 -3.53 4.526 c
-3.687 4.656 -4.023 4.897 -4.1 5.244 c
-4.164 5.532 -4.025 5.669 -3.927 5.723 c
-3.772 5.808 -3.609 5.804 -3.482 5.676 c
-3.354 5.549 -3.341 5.389 -3.277 5.311 c
-3.214 5.229 -3.051 5.181 -2.976 5.149 c
-2.875 5.106 -2.769 5.065 -2.643 5.032 c
-2.598 5.021 -2.38 4.925 -2.339 5.021 c
-2.302 5.102 -2.351 5.196 -2.389 5.311 c
-2.47 5.532 -3.008 5.771 -3.07 5.837 c
-3.134 5.899 -3.335 6.063 -3.403 6.377 c
-3.467 6.671 -3.468 6.71 -3.53 6.857 c
-3.637 7.108 -3.585 7.299 -3.552 7.427 c
-3.51 7.591 -3.627 7.705 -3.547 7.8 c
-3.446 7.916 -3.299 7.981 -3.198 7.911 c
-3.122 7.856 -3.023 7.773 -2.96 7.726 c
-2.895 7.676 -2.854 7.64 -2.707 7.554 c
-2.596 7.489 -2.439 7.54 -2.327 7.512 c
-2.242 7.489 -2.082 7.349 -2.074 7.364 c
-2.025 7.443 -2.058 7.561 -2.074 7.688 c
-2.09 7.814 -2.216 8.07 -2.247 8.151 c
-2.28 8.23 -2.31 8.359 -2.231 8.469 c
-2.153 8.582 -1.963 8.82 -1.868 8.932 c
-1.773 9.045 -1.661 9.284 -1.504 9.061 c
-1.344 8.836 -1.282 8.694 -1.202 8.646 c
-1.124 8.597 -1.039 8.597 -.917 8.63 c
-.799 8.661 -.646 8.694 -.537 8.726 c
-.426 8.755 -.346 8.836 -.252 8.902 c
-.157 8.965 -.093 8.98 -.03 8.948 c
.033 8.917 .059 8.874 .097 8.789 c
.122 8.729 .122 8.63 .144 8.55 c
.184 8.396 .229 8.322 .207 8.263 c
.159 8.129 .065 8.024 .033 7.927 c
0 7.831 .059 7.567 .018 7.496 c
-.046 7.383 -.109 7.352 -.141 7.239 c
-.173 7.13 -.141 7.001 -.093 6.905 c
-.046 6.811 -.046 6.714 -.03 6.634 c
-.014 6.554 .082 6.603 .144 6.681 c
.207 6.762 .207 6.841 .271 6.953 c
.334 7.064 .491 7.064 .635 7.082 c
.764 7.095 .925 7.258 1.063 7.273 c
1.141 7.281 1.285 7.242 1.348 7.13 c
1.442 6.957 1.458 6.793 1.378 6.664 c
1.3 6.539 1.18 6.429 1.143 6.282 c
1.094 6.097 1.074 5.872 .968 5.723 c
.866 5.581 .727 5.501 .635 5.358 c
.533 5.191 .508 4.877 .555 4.718 c
.604 4.558 .661 4.602 .698 4.687 c
.746 4.795 .787 4.904 .888 4.957 c
1.086 5.061 1.327 5.17 1.475 5.181 c
1.554 5.186 1.712 5.102 1.775 4.973 c
1.839 4.846 1.816 4.657 1.79 4.526 c
1.737 4.276 1.671 4.01 1.602 3.921 c
1.505 3.796 1.391 3.694 1.237 3.584 c
1.08 3.473 .715 3.298 .57 3.201 c
.407 3.091 .323 2.923 .292 2.797 c
.261 2.673 .302 2.578 .382 2.578 c
.46 2.578 .555 2.721 .604 2.785 c
.65 2.851 .705 2.992 .798 3.009 c
.904 3.03 1.031 2.963 1.143 2.963 c
1.253 2.963 1.316 3.009 1.442 3.042 c
1.569 3.073 1.649 2.999 1.632 2.871 c
1.616 2.744 1.616 2.674 1.553 2.593 c
1.49 2.513 1.316 2.419 1.3 2.307 c
1.284 2.194 1.318 2.064 1.3 1.972 c
1.273 1.838 1.143 1.747 1.016 1.635 c
.888 1.525 .46 1.179 .367 .981 c
.3 .844 .3 .566 .318 .454 c
.345 .294 .398 .262 y
.431 .262 .132 .139 .121 .127 c
.047 .055 0 0 y
h
S 1 0 0 1 1.403 6.747 cm 0 0 m
.079 .046 .119 .094 .222 .199 c
.324 .301 .436 .422 .505 .501 c
.559 .56 .696 .684 .768 .806 c
.828 .905 .87 .941 .95 .949 c
.997 .953 1.107 .949 1.164 .972 c
1.22 .996 1.367 1.077 1.417 1.115 c
1.456 1.149 1.679 1.195 1.728 1.021 c
1.777 .829 1.784 .588 1.757 .526 c
1.693 .374 1.6 .262 1.552 .11 c
1.522 .022 1.527 -.153 1.583 -.312 c
1.633 -.459 1.703 -.393 1.798 -.337 c
1.893 -.281 1.964 -.25 2.041 -.258 c
2.121 -.266 2.462 -.312 2.51 -.322 c
2.556 -.328 2.636 -.37 2.612 -.449 c
2.589 -.527 2.431 -.817 2.312 -.92 c
2.192 -1.024 2.105 -1.111 2.083 -1.175 c
2.058 -1.238 1.995 -1.406 1.985 -1.487 c
1.979 -1.566 1.853 -1.718 1.78 -1.765 c
1.709 -1.812 1.393 -2.014 1.346 -2.054 c
1.299 -2.091 1.11 -2.161 1.274 -2.349 c
1.393 -2.484 1.4 -2.421 1.456 -2.413 c
1.513 -2.403 1.545 -2.391 1.646 -2.324 c
1.757 -2.254 1.86 -2.229 1.972 -2.277 c
2.083 -2.324 2.163 -2.357 2.192 -2.403 c
2.257 -2.499 2.202 -2.581 2.176 -2.62 c
2.146 -2.671 1.868 -2.946 1.813 -3.003 c
1.757 -3.059 1.527 -3.259 1.456 -3.315 c
1.387 -3.371 1.22 -3.529 1.171 -3.633 c
1.124 -3.738 1.068 -3.953 1.021 -4.034 c
.974 -4.113 .775 -4.295 .607 -4.407 c
.442 -4.52 .135 -4.736 .071 -4.847 c
.027 -4.922 -.008 -5.127 -.025 -5.288 c
-.04 -5.446 0 -5.589 y
-.119 -5.614 -.205 -5.638 v
-.294 -5.662 -.364 -5.741 -.364 -5.798 c
-.364 -5.853 -.491 -5.988 y
-.477 -5.853 -.554 -5.766 v
-.634 -5.676 -.713 -5.567 -.761 -5.542 c
S
Q
q 1 0 0 1 576.579 25.908 cm 0 0 m
.054 .175 l
-.08 .388 -.135 .459 v
-.19 .531 -.809 1.001 -.901 1.074 c
-.995 1.145 -1.305 1.351 -1.409 1.39 c
-2.032 1.677 -2.075 1.693 v
-2.12 1.712 -2.419 1.883 -2.468 1.909 c
-2.517 1.936 -2.639 2.005 -2.678 2.031 c
-2.715 2.059 -2.748 2.122 -2.748 2.148 c
-2.748 2.176 -2.731 2.227 -2.71 2.221 c
-2.687 2.216 -2.639 2.221 -2.616 2.197 c
-2.596 2.176 -2.507 2.138 -2.456 2.109 c
-2.406 2.081 -2.037 1.901 -1.993 1.879 c
-1.949 1.854 -1.623 1.689 -1.574 1.671 c
-1.523 1.654 -1.294 1.545 -1.255 1.522 c
-1.217 1.501 -1.133 1.445 -1.077 1.418 c
-1.021 1.39 -.901 1.316 -.873 1.297 c
-.848 1.272 -.72 1.179 -.692 1.145 c
-.664 1.114 -.477 .996 -.454 .978 c
-.433 .964 -.301 .836 -.278 .825 c
-.257 .813 -.18 .759 -.162 .754 c
-.146 .747 -.112 .729 -.092 .74 c
-.067 .754 -.057 .818 -.063 .852 c
-.067 .886 -.162 1.346 -.18 1.424 c
-.194 1.501 -.262 1.833 -.278 1.888 c
-.296 1.942 -.41 2.109 -.516 2.187 c
-.619 2.266 -1.105 2.664 -1.166 2.702 c
-1.227 2.739 -1.508 2.946 -1.585 2.984 c
-1.663 3.024 -1.91 3.179 -1.977 3.223 c
-2.044 3.268 -2.374 3.495 -2.43 3.545 c
-2.484 3.594 -2.864 4.004 -2.936 4.082 c
-3.009 4.16 -3.274 4.55 -3.332 4.646 c
-3.393 4.747 -3.538 4.891 -3.603 4.974 c
-3.671 5.057 -3.734 5.167 -3.741 5.207 c
-3.746 5.247 -3.696 5.334 -3.603 5.258 c
-3.511 5.179 -3.454 5.124 -3.399 5.086 c
-3.344 5.046 -3.3 5.003 -3.262 4.945 c
-3.224 4.891 -3.151 4.796 -3.123 4.753 c
-3.096 4.708 -2.97 4.515 -2.926 4.454 c
-2.883 4.392 -2.706 4.136 -2.605 4.022 c
-2.507 3.903 -2.253 3.635 -1.784 3.351 c
-1.317 3.068 -.757 2.691 -.697 2.658 c
-.637 2.623 -.592 2.576 -.554 2.576 c
-.516 2.576 -.498 2.598 -.487 2.623 c
-.477 2.652 -.521 2.758 -.544 2.829 c
-.565 2.901 -.603 3.279 -.626 3.383 c
-.648 3.488 -.823 4.42 -.848 4.499 c
-.867 4.575 -.852 4.715 -1.001 4.806 c
-1.148 4.902 -1.547 5.194 -1.618 5.252 c
-1.69 5.306 -2.264 5.859 -2.324 5.927 c
-2.386 5.992 -2.673 6.332 -2.721 6.38 c
-2.771 6.432 -2.941 6.636 -2.981 6.741 c
-3.018 6.846 -3.047 6.912 -3.079 6.99 c
-3.113 7.068 -3.185 7.234 -3.206 7.283 c
-3.228 7.335 -3.25 7.416 -3.245 7.434 c
-3.239 7.45 -3.218 7.473 -3.175 7.45 c
-3.129 7.428 -3.024 7.29 -3.004 7.251 c
-2.981 7.213 -2.876 7.046 -2.858 7.002 c
-2.843 6.958 -2.803 6.868 -2.776 6.823 c
-2.748 6.781 -2.534 6.476 -2.462 6.402 c
-2.391 6.332 -2.147 6.07 -2.087 6.016 c
-2.027 5.961 -1.518 5.449 -1.435 5.379 c
-1.353 5.306 -1.188 5.2 -1.144 5.184 c
-1.101 5.167 -1.057 5.167 -1.035 5.179 c
-1.011 5.189 -.984 5.222 -.99 5.322 c
-.995 5.423 -1.105 6.353 -1.128 6.486 c
-1.148 6.621 -1.271 7.022 -1.3 7.135 c
-1.325 7.245 -1.364 7.571 -1.392 7.794 c
-1.419 8.016 -1.568 8.645 -1.613 8.737 c
-1.657 8.824 -1.686 8.912 -1.705 8.963 c
-1.728 9.012 -1.767 9.105 -1.739 9.152 c
-1.714 9.195 -1.646 9.339 -1.613 9.334 c
-1.579 9.329 -1.534 9.31 -1.514 9.272 c
-1.491 9.233 -1.446 8.984 -1.435 8.935 c
-1.426 8.884 -1.31 8.337 -1.305 8.293 c
-1.3 8.247 -1.242 8.098 -1.232 8.038 c
-1.223 7.976 -1.184 7.728 -1.178 7.622 c
-1.172 7.517 -1.139 7.406 -1.111 7.385 c
-1.083 7.361 -1.05 7.367 -1.018 7.379 c
-.984 7.389 -.945 7.522 -.911 7.583 c
-.88 7.643 -.71 7.905 -.671 7.947 c
-.631 7.991 -.537 8.198 -.516 8.237 c
-.493 8.275 -.388 8.48 -.356 8.535 c
-.321 8.592 -.229 8.714 -.2 8.755 c
-.174 8.79 -.129 8.867 -.102 8.863 c
-.074 8.857 -.009 8.824 y
.048 8.784 .014 8.709 v
-.018 8.63 -.14 8.486 -.174 8.432 c
-.207 8.377 -.345 8.128 -.388 8.026 c
-.433 7.928 -.615 7.711 -.644 7.667 c
-.671 7.622 -.775 7.373 -.813 7.283 c
-.852 7.193 -.919 7.018 -.935 6.924 c
-.95 6.83 -.919 6.396 -.906 6.332 c
-.896 6.265 -.79 5.526 -.78 5.395 c
-.769 5.262 -.736 5.057 -.72 4.997 c
-.702 4.935 -.687 4.764 -.676 4.663 c
-.664 4.564 -.659 4.509 -.631 4.481 c
-.603 4.454 -.565 4.447 -.544 4.465 c
-.521 4.481 -.382 4.698 -.349 4.747 c
-.316 4.796 -.169 5.04 -.146 5.067 c
-.123 5.097 .108 5.35 .18 5.407 c
.253 5.461 .394 5.59 .449 5.683 c
.505 5.776 .561 5.882 .621 6.032 c
.681 6.182 .731 6.409 .77 6.47 c
.81 6.529 .896 6.697 .931 6.741 c
.963 6.787 1.14 7.002 1.194 7.033 c
1.25 7.068 1.305 7.117 1.338 7.117 c
1.37 7.117 1.403 7.074 1.397 7.04 c
1.394 7.008 1.338 6.944 1.315 6.92 c
1.296 6.891 1.129 6.691 1.101 6.636 c
1.072 6.581 .913 6.265 .896 6.192 c
.88 6.121 .831 5.91 .798 5.844 c
.764 5.776 .72 5.667 .647 5.566 c
.576 5.467 .466 5.362 .372 5.272 c
.279 5.184 .081 5.029 .004 4.895 c
-.074 4.764 -.339 4.38 -.373 4.277 c
-.406 4.172 -.576 3.938 -.472 3.523 c
-.367 3.107 -.333 3.019 y
-.321 2.901 -.262 2.936 v
-.2 2.968 -.146 3.102 -.097 3.156 c
-.047 3.212 .141 3.434 .19 3.477 c
.24 3.523 .389 3.665 .477 3.738 c
.566 3.811 .852 4.031 .907 4.071 c
.963 4.11 1.167 4.287 1.212 4.337 c
1.255 4.388 1.382 4.582 1.409 4.612 c
1.438 4.646 1.496 4.708 1.531 4.708 c
1.564 4.708 1.619 4.675 1.603 4.612 c
1.586 4.555 1.543 4.475 1.491 4.397 c
1.442 4.321 1.37 4.216 1.338 4.176 c
1.305 4.136 1.194 4.056 1.145 4.009 c
1.095 3.967 .88 3.827 .81 3.761 c
.736 3.695 .652 3.635 .512 3.502 c
.365 3.366 .312 3.323 .229 3.223 c
.147 3.125 0 2.885 -.041 2.792 c
-.08 2.696 -.135 2.498 -.135 2.427 c
-.135 2.353 -.097 2.031 -.063 1.883 c
-.03 1.732 -.03 1.599 .014 1.549 c
.059 1.501 .091 1.506 .118 1.527 c
.147 1.549 .168 1.645 .208 1.693 c
.246 1.743 .284 1.788 .322 1.833 c
.362 1.879 .5 1.993 .543 2.026 c
.587 2.059 .692 2.148 .746 2.187 c
.804 2.227 .958 2.387 1.013 2.42 c
1.067 2.455 1.15 2.514 1.188 2.52 c
1.229 2.524 1.319 2.547 1.343 2.542 c
1.366 2.538 1.426 2.504 1.388 2.458 c
1.349 2.414 1.217 2.298 1.188 2.275 c
1.161 2.254 1.007 2.122 .936 2.059 c
.862 1.999 .72 1.904 .665 1.86 c
.61 1.816 .517 1.727 .472 1.671 c
.429 1.615 .362 1.506 .328 1.424 c
.295 1.339 .246 1.114 .229 .99 c
.212 .867 .24 .724 .253 .687 c
.263 .646 .267 .609 .279 .575 c
.29 .543 .345 .452 .365 .569 c
.389 .687 .417 .874 .477 .946 c
.537 1.02 .715 1.25 .731 1.095 c
.746 .94 .556 .598 .569 .475 c
.587 .354 .551 .192 .482 .092 c
.417 -.007 .196 -.072 .158 -.067 c
.118 -.062 0 0 y
f
Q
q 1 0 0 1 578.21 27.082 cm 0 0 m
.164 .542 .176 .587 v
.188 .631 .131 .741 .121 .775 c
.109 .81 .054 .932 .054 .984 c
.054 1.042 .065 1.107 .109 1.13 c
.153 1.153 .176 1.175 .231 1.239 c
.285 1.308 .341 1.363 .351 1.462 c
.363 1.561 .351 1.596 .386 1.673 c
.418 1.75 .462 1.817 .551 1.872 c
.638 1.928 .693 1.993 .772 2.037 c
.849 2.081 .926 2.172 .98 2.228 c
1.036 2.282 1.148 2.393 1.213 2.427 c
1.279 2.461 1.345 2.482 1.411 2.491 c
1.476 2.505 1.521 2.516 1.599 2.537 c
1.676 2.56 1.753 2.659 1.775 2.692 c
1.797 2.726 1.786 2.825 1.664 2.78 c
1.543 2.735 1.366 2.692 1.313 2.682 c
1.256 2.669 1.114 2.637 1.07 2.592 c
1.025 2.549 .97 2.461 .849 2.383 c
.728 2.304 .65 2.206 .584 2.206 c
.517 2.206 .484 2.206 .508 2.315 c
.529 2.427 .54 2.592 .574 2.726 c
.606 2.857 .65 3.058 .672 3.157 c
.693 3.259 .737 3.445 .804 3.469 c
.87 3.489 .991 3.545 1.091 3.645 c
1.19 3.744 1.323 3.866 1.4 3.954 c
1.476 4.042 1.599 4.276 1.664 4.331 c
1.73 4.388 1.84 4.509 1.952 4.553 c
2.062 4.598 1.996 4.589 2.161 4.62 c
2.326 4.653 2.37 4.644 2.437 4.686 c
2.503 4.731 2.548 4.775 2.514 4.786 c
2.481 4.797 2.481 4.797 2.415 4.831 c
2.349 4.863 2.293 4.907 2.216 4.887 c
2.14 4.863 2.05 4.843 1.974 4.809 c
1.897 4.775 1.709 4.696 1.653 4.62 c
1.599 4.542 1.433 4.366 1.378 4.299 c
1.323 4.233 1.224 4.11 1.179 4.057 c
1.134 3.999 1.08 3.945 1.025 3.912 c
.97 3.878 .837 3.844 .87 3.978 c
.904 4.11 .915 4.255 .949 4.398 c
.98 4.542 1.014 4.809 1.091 4.887 c
1.168 4.965 1.289 5.098 1.345 5.151 c
1.4 5.206 1.476 5.328 1.378 5.317 c
1.279 5.307 1.224 5.417 1.235 5.496 c
1.245 5.574 1.279 5.827 1.313 5.938 c
1.345 6.05 1.423 6.248 1.456 6.315 c
1.488 6.381 1.5 6.436 1.588 6.525 c
1.676 6.615 1.808 6.647 1.719 6.727 c
1.631 6.803 1.313 6.959 1.411 6.925 c
1.51 6.892 1.4 6.77 1.389 6.727 c
1.378 6.682 1.323 6.626 1.289 6.525 c
1.256 6.427 1.19 6.283 1.168 6.183 c
1.148 6.082 1.058 5.807 1.047 5.672 c
1.036 5.539 .991 5.496 .991 5.45 c
.991 5.406 .915 5.328 .86 5.429 c
.804 5.528 .804 5.607 .782 5.695 c
.76 5.783 .772 5.871 .76 5.928 c
.75 5.982 .617 6.082 .617 5.938 c
.617 5.794 .606 5.761 .617 5.695 c
.627 5.628 .627 5.561 .638 5.474 c
.65 5.385 .716 5.131 .75 5.074 c
.782 5.019 .849 4.887 .826 4.775 c
.804 4.664 .75 4.589 .728 4.509 c
.704 4.434 .661 4.276 .508 4.441 c
.351 4.609 -.065 5.273 -.1 5.317 c
-.134 5.363 -.177 5.395 -.221 5.284 c
-.265 5.175 -.299 5.295 -.211 5.141 c
-.123 4.986 -.033 4.852 .021 4.731 c
.076 4.609 .176 4.498 .231 4.419 c
.285 4.344 .351 4.276 .407 4.188 c
.462 4.1 .484 4.089 .473 3.889 c
.462 3.689 .407 3.29 .351 2.914 c
.297 2.537 .231 2.206 .176 2.116 c
.121 2.027 .109 1.982 0 2.072 c
-.111 2.16 -.078 2.26 -.123 2.304 c
-.167 2.351 -.243 2.404 -.32 2.36 c
-.397 2.315 -.541 2.238 -.53 2.172 c
-.519 2.105 -.608 2.126 -.464 2.072 c
-.32 2.016 -.299 2.006 -.265 1.95 c
-.233 1.895 -.221 1.883 -.177 1.829 c
-.134 1.772 -.1 1.807 -.012 1.772 c
.076 1.739 .099 1.783 .131 1.693 c
.164 1.607 .241 1.65 .164 1.484 c
.087 1.318 -.055 1.283 -.111 1.153 c
-.167 1.02 -.155 .942 -.155 .842 c
-.155 .741 -.167 .676 -.221 .566 c
-.276 .453 -.199 .532 -.403 .343 c
-.608 .155 -.795 .044 -.815 -.057 c
-.838 -.154 -.905 -.2 -.838 -.243 c
-.772 -.288 -.739 -.255 -.696 -.345 c
-.649 -.433 -.597 -.441 -.597 -.531 c
-.597 -.619 -.331 -.401 y
0 0 l
f
Q
EMC
EMC
endstream
endobj
67 0 obj
<>stream
Adobe Illustrator CS4
2020-04-30T06:52:19+05:30
136
256
JPEG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282.222222
211.666667
Millimeters
1
False
False
Cyan
Magenta
Yellow
Black
Default Swatch Group
0
application/postscript
endstream
endobj
68 0 obj
<>stream
hn0{i
hDU\ٵAz#j`J)Rgxė-P "Kv<(,nH[
\4 Y}fAb \pV`c~x1GXjsb 3 @l{r}r/Q!0\WP6*I\(ht[T6ӯ+#;J<ʖ(4$og0é-L:Jׁ7"1:1zJJ0Tx0J
vFh
Jk89rW<.3UA7E!Ӿ
HYִ@1FC_[];gwfdM 2A& 係aʍϵ0 o
endstream
endobj
70 0 obj
<>stream
/GS1 gs
BT
/F6 1 Tf
10.4607 0 0 10.4607 62.022 698.2297 Tm
/Cs8 cs 1 scn
0 Tc
0 Tw
[(Imaging)-297.2(and)-298.4(quantication)]TJ
/F5 1 Tf
10.959 0 0 10.959 62.022 685.2471 Tm
0 0 0 rg
[(Cells)-236.8(were)-237.7(imaged)-232(at)-238.7(20)]TJ
/F8 1 Tf
9.5186 0 TD
()Tj
/F5 1 Tf
.7191 0 TD
[(magnication)-231.8(using)-236.7(a)-240.7(Hama-)]TJ
-10.2377 -1.1795 TD
[(matsu)-286.1(Orca)-278.8(1-megapixel)-282.5(CCD)-281.8(camera)-284(tted)-282.8(to)-284.4(a)-282.1(Leica)]TJ
0 -1.1847 TD
[(DMIRBE)-308.4(microscope.)-314.8(Images)-309.8(were)-315.3(captured)-312.5(and)-312.6(ana-)]TJ
0 -1.1795 TD
[(lyzed)-205.9(using)-200.5(Volocity)-202.1(\(Improvision\).)-205.7(Four)-201.5(elds)-205.6(were)-201.5(se-)]TJ
0 -1.1847 TD
[(lected)-463.2(at)-461.2(consistent)-458.5(areas)-460(of)-460.9(the)-458.2(peri-lesional)-463.7(region)]TJ
0 -1.1795 TD
[(corresponding)-537(to)-532.7(each)-533.1(corner)-534(of)-533.3(the)-535.8(injury)-535(site)-535.9(in)]TJ
T*
[(each)-300.3(of)-305.7(the)-297.8(sections)-303.1(using)-303.9(standard)-301.8(DAPI,)-300.8(uorescein,)]TJ
0 -1.1847 TD
[(and)-364.4(Rhodamine)-366.3(lter)-366.7(sets.)-363.9(To)-365.5(quantify)-364.3(the)-365(cell)-364.8(num-)]TJ
0 -1.1795 TD
[(bers,)-584.9(a)-587.3(200-)]TJ
/F12 1 Tf
5.2611 0 TD
(l)Tj
/F5 1 Tf
.5535 0 TD
(m)Tj
/F8 1 Tf
.9777 0 TD
()Tj
/F5 1 Tf
.7139 0 TD
(200-)Tj
/F12 1 Tf
1.7899 0 TD
(l)Tj
/F5 1 Tf
.5535 0 TD
[(m)-584.8(\(40,000)]TJ
/F12 1 Tf
4.5162 0 TD
(l)Tj
/F5 1 Tf
.5535 0 TD
(m)Tj
8.2191 0 0 7.3052 234.4251 586.5447 Tm
(2)Tj
10.959 0 0 10.959 238.3369 581.6691 Tm
[(\))-588.2(square)-586.1(grid)]TJ
-16.0886 -1.1847 TD
[(was)-410.2(placed)-415.6(at)-409.4(random)-411(within)-408.8(each)-414.1(of)-409.2(the)-411.6(four)-409.8(elds)]TJ
0 -1.1795 TD
[(around)-801.3(the)-799.6(peri-lesional)-794.8(area.)-802.6(Cell)-797.3(counts)-802.4(were)]TJ
0 -1.1847 TD
[(obtained)-398.7(in)-404.4(each)-398.6(area)-399.8(for)-402.1(Hoechst,)-398.8(EdU,)-402.4(GFAP,)-398.6(and)]TJ
0 -1.1795 TD
[(double-labeled)-508.9(cells)-507.8(per)-510.6(40,000-)]TJ
/F12 1 Tf
13.3364 0 TD
(l)Tj
/F5 1 Tf
.5484 0 TD
(m)Tj
8.2191 0 0 7.3052 223.0865 534.7274 Tm
(2)Tj
10.959 0 0 10.959 232.611 529.8518 Tm
[(grid.)-507.9(For)-509.4(three)]TJ
-15.5661 -1.1847 TD
[(brains)-306.8(in)-300.9(each)-305.5(group)-302.2(at)-306(least)-305.5(three)-304.1(sections)-303.1(containing)]TJ
0 -1.1795 TD
[(the)-308.1(injury)-307.4(site)-308.3(were)-310.1(analyzed.)-305.9(All)-308.1(images)-310.4(for)-303.8(presenta-)]TJ
0 -1.1847 TD
[(tion)-280(were)-279.1(taken)-282.6(with)-278.6(a)-282.1(Leica)-283.5(SP5)-280.9(confocal)-280.6(microscope.)]TJ
/F6 1 Tf
10.4607 0 0 10.4607 62.022 458.4188 Tm
/Cs8 cs 1 scn
[(Statistical)-301.5(analysis)]TJ
/F5 1 Tf
10.959 0 0 10.959 62.022 445.4928 Tm
0 0 0 rg
[(A)-461.4(mixed)-457.2(analysis)-458.5(of)-460.9(variance)-457.8(\(ANOVA\))-462.3(model)-455.9(was)]TJ
T*
[(used)-699.4(to)-693.1(analyze)-697.3(data)-694(obtained)-693.6(from)-697.2(the)-691(rotarod)]TJ
0 -1.1795 TD
[(motor)-232.8(test.)-234.5(Our)-234.2(ANOVA)-232.6(model)-228.3(used)-233.8(treatment)-236.2(groups)]TJ
0 -1.1847 TD
[(\(SAG,)-240.2(cyclopamine,)-244.8(and)-240.2(control\))-239.7(as)-238.8(a)-245.9(between-subje)7.3(cts)]TJ
0 -1.1795 TD
[(factor,)-219(and)-219.5(days)-217.9(post-injury)-217.7(\(dpi;)-218.6(0,)-218.7(3,)-218.7(7,)-218.7(14,)-220.8(and)-219.5(28)-164.6(dpi\))]TJ
T*
[(as)-306.1(a)-302.8(within-subjects)-300.9(factor.)-306.9(Mauchlys)-302.7(test)-302.5(was)-306.8(used)-306.2(to)]TJ
0 -1.1847 TD
[(evaluate)-395.6(model)-393.8(sphericity.)-396.9(The)-394.5(Bonferroni)-394.2(correction)]TJ
0 -1.1795 TD
[(method)-281.6(was)-286.1(used)-280.3(to)-284.4(allow)-281.2(for)-283.2(repeated)-287.2(measures)-285.2(anal-)]TJ
0 -1.1847 TD
-.0002 Tc
[(ysis.)-452(Independent-samples)]TJ
/F10 1 Tf
11.1482 0 TD
0 Tc
(t)Tj
/F5 1 Tf
.7501 0 TD
[(tests)-450.6(were)-444.6(conducted)-453.2(to)]TJ
-11.8983 -1.1795 TD
[(study)-314(the)-308.1(effect)-314.9(at)-311.2(each)-315.8(time-point.)-310.6(Statistical)-309.5(analyses)]TJ
0 -1.1847 TD
[(were)-222.2(completed)-219.4(in)-218.1(IBM)-221.7(SPSS)-217.1(\(version)-220.1(22.0.0.0\).)-223.4(Results)]TJ
0 -1.1795 TD
[(from)-371.3(the)-370.2(histological)-365.9(studies)-368.3(were)-372.2(analyzed)-368.7(using)-371.2(the)]TJ
0 -1.1847 TD
[(Graphpad)-365.4(Prism)-364.3(stats)-362.4(package.)-364.8(Statistical)-366.5(signicance)]TJ
0 -1.1795 TD
[(was)-617.2(assessed)-624.6(using)-619.5(one-way)-615.9(ANOVA)-615.4(or)-620.7(Kruskal-)]TJ
0 -1.1847 TD
[(Wallis)-300.8(test,)-296.6(followed)-300(by)-299.1(appropriate)-300.4(post)-300.5(hoc)-296.4(tests.)]TJ
/F4 1 Tf
10.4607 0 0 10.4607 62.022 231.5905 Tm
/Cs8 cs 1 scn
(Results)Tj
/F6 1 Tf
0 -1.2357 TD
[(Shh)-255.1(protein)-250.8(levels)-253.1(decrease)-251.3(in)-254.1(the)-251.9(CSF)-253.9(of)-257.3(patients)]TJ
0 -1.2411 TD
[(with)-297.9(severe)-301(TBI)]TJ
/F5 1 Tf
10.959 0 0 10.959 62.022 192.7559 Tm
0 0 0 rg
[(There)-224.9(are)-221.2(limited)-221.9(data)-223.3(on)-226.4(the)-220.2(level)-222.4(of)-223(Shh)-223.7(in)-223.3(the)-225.4(human)]TJ
0 -1.1847 TD
[(central)-217.6(nervous)-215.1(system.)-216.5(To)-215.5(determine)-215.7(if)-214.6(Shh)-218.5(levels)-215.3(were)]TJ
0 -1.1795 TD
[(altered)-280(by)-278.4(TBI,)-274.7(we)-277.9(compared)-277.7(the)-282.3(concentration)-273.5(of)-279.9(Shh)]TJ
T*
[(protein)-428.6(in)-430.2(the)-427.1(CSF)-425.3(of)-429.9(patients)-427.5(requiring)-424.9(an)-429.1(external)]TJ
0 -1.1847 TD
[(ventricular)-302(drain)-304.2(\(EVD\))-300.6(following)-297.8(a)-302.8(severe)-302.6(TBI)-301.3(\(Glas-)]TJ
0 -1.1795 TD
[(gow)-217(Coma)-212.7(Scale)-216.8(score)]TJ
/F8 1 Tf
8.9496 0 TD
(<)Tj
/F5 1 Tf
.5484 0 TD
[(8,)-218.7(with)-216.5(raised)-215.3(intracranial)-212.5(pres-)]TJ
-9.4979 -1.1847 TD
[(sure)-213.9(necessitating)-215.2(an)-217(EVD)-215.8(to)-211.9(relieve)-213.5(that)-212.8(pressure\))-219.3(with)]TJ
0 -1.1795 TD
[(CSF)-311.5(of)-316.1(non-TBI)-310.5(patients.)-313(CSF)-316.6(from)-309.2(patients)-313.7(with)-314.8(TBI)]TJ
0 -1.1847 TD
[(was)-265.4(obtained)-269.4(at)-264.6(a)-271.7(median)-262.8(of)-269.5(1.5)-267.3(days)-269.6(from)-262.7(injury)-271.2(\(me-)]TJ
0 -1.1795 TD
[(dian,)-320.9(1.5)-324.2(days;)-320.6(range,)-323.3(03)-316.8(days\).)-324.2(In)-321(patients)-324.1(with)-320(TBI,)]TJ
0 -1.1847 TD
[(the)-380.6(level)-382.8(of)-378.1(Shh)-384.1(in)-378.5(CSF)-383.9(was)-379.2(signicantly)-381.1(lower)-379.6(com-)]TJ
22.9068 26.0573 TD
[(pared)-334.8(with)-335.5(uninjured)-330.7(control)-334.4(patients)-329.2(\(10.5)-164.4(pg/mL)-336.8(vs.)]TJ
0 -1.1847 TD
[(483.1)-168.1(pg/mL;)]TJ
/F10 1 Tf
5.4629 0 TD
(p)Tj
/F8 1 Tf
.6467 0 TD
(<)Tj
/F5 1 Tf
.7139 0 TD
[(0.01,)-299.8(Mann-Whitney)-299.8(U)-300.5(test;)-296.6(Fig.)-302.9(1\).)]TJ
-5.8198 -1.1795 TD
[(Next,)-505.7(we)-505.5(demonstrated)-507(that)-502.5(human)-506.1(cortical)-505.5(cells)]TJ
-1.0036 -1.1847 TD
[(contain)-350.1(Shh)-347.9(signaling)-347.1(components.)-343.3(Patients)-349.3(undergo-)]TJ
0 -1.1795 TD
[(ing)-618.9(either)-618.4(epilepsy)-619(surgery)-620.3(or)-615.5(tumor)-621.5(surgery)-615.2(had)]TJ
T*
[(resected)-428()42.1(normal)49.8()-428.6(access)-427.1(tissue)-427.9(frozen)-425.9(and)-426.4(analyzed.)]TJ
0 -1.1847 TD
[(Human)-390.9(cDNA)-388.1(from)-392(cortical)-386.6(and)-395.4(hippocampal)-384.1(tissue)]TJ
0 -1.1795 TD
[(demonstrated)-620.8(expression)-618.8(of)-616.1(Shh)-616.9(and)-617.8(its)-615.6(receptors)]TJ
0 -1.1847 TD
[(Smoothened)-555.2(and)-550.6(Patched1.)-552.5(Expression)-555.6(of)-554(all)-552.9(three)]TJ
0 -1.1795 TD
[(genes)-469.2(was)-462(demonstrated)-460.4(in)-466.4(both)-458.7(brain)-463.9(regions)-464.8(with)]TJ
0 -1.1847 TD
[(no)-459.2(signicant)-452.8(difference)-455.9(in)-456.1(levels)-453.3(between)-451.5(cortex)-456.9(or)]TJ
0 -1.1795 TD
[(hippocampus)-300.9(\(Table)-300.8(2\).)]TJ
ET
/Cs8 cs 1 scn
1 i
q 1 0 0 1 313.058 699.364 cm 0 0 m
.113 1.02 l
.595 3.471 2.504 5.45 4.989 5.896 c
6.009 5.953 l
6.009 4.989 l
5.159 4.876 l
3.116 4.586 1.44 2.856 1.077 .85 c
1.02 0 l
f*
Q
q 1 0 0 1 547.54 705.316 cm 0 0 m
1.02 -.057 l
3.204 -.362 5.663 -2.708 5.839 -4.932 c
5.953 -5.953 l
4.989 -5.953 l
4.876 -5.102 l
4.573 -3.084 2.869 -1.38 .85 -1.077 c
0 -.964 l
f*
Q
319.068 704.353 228.472 .96381 re
f
q 1 0 0 1 319.068 380.126 cm 0 0 m
-1.02 .113 l
-3.474 .397 -5.449 2.568 -5.896 4.932 c
-6.009 5.953 l
-4.989 5.953 l
-4.932 5.102 l
-4.532 3.106 -2.916 1.363 -.85 1.077 c
0 1.02 l
f*
Q
q 1 0 0 1 553.493 386.079 cm 0 0 m
-.057 -1.02 l
-.362 -3.204 -2.708 -5.663 -4.932 -5.839 c
-5.953 -5.953 l
-5.953 -4.932 l
-5.102 -4.876 l
-3.084 -4.573 -1.38 -2.869 -1.077 -.85 c
-.964 0 l
f*
Q
319.068 380.126 228.472 1.0205 re
f
313.058 386.079 1.0205 313.285 re
f
552.529 386.079 .96381 313.285 re
f
q
331.143 695.338 m
535.464 695.338 l
535.464 573.109 l
331.143 573.109 l
W n
q
204.461 0 0 122.23 331.143 573.109 cm
/Im1 Do
Q
Q
BT
/F4 1 Tf
9.9626 0 0 9.9626 330.0093 555.1935 Tm
0 0 0 rg
[(FIG)-7.2(.)-330.4(1)0(.)]TJ
/F6 1 Tf
3.8753 0 TD
[(Shh)-301.9(is)-303.6(reduced)-310.3(in)-300.2(CSF)-303.7(followi)-10.7(ng)-301.6(TBI)-300.2(in)]TJ
-3.8753 -1.2974 TD
[(hum)-8.8(an)-300.6(patien)-7.8(ts.)-303.8(CSF)-303.7(was)-303.3(collect)-10.7(ed)-303.7(from)-306.3(externa)-8.1(l)]TJ
0 -1.3031 TD
[(vent)-7.8(ricular)-304.7(dra)-8.4(ins)-303.5(in)-300.2(patie)-7.8(nts)-301.6(who)-306.2(had)-301.9(suffer)-10.2(ed)-298(a)]TJ
0 -1.2975 TD
[(severe)-308.6(TBI)-305.9(or)-303.6(from)-306.3(a)-300.6(control)-306.6(gro)-7.6(up)-302.6(undergo)-9.3(ing)]TJ
0 -1.3031 TD
[(rout)-9.6(ine)-301(lumba)-7.8(r)-298.3(punc)-9.2(ture.)-308.8(The)-302.7(concentrat)-11.5(ion)-305.5(of)]TJ
0 -1.2974 TD
[(Shh)-307.6(was)-303.3(determi)-9.7(ned)-303.7(by)-301.6(ELISA)-304.5(and)-307.6(was)]TJ
0 -1.3031 TD
[(sign)-7.6(icantly)-310.6(lower)-302.3(in)-305.9(patients)-309.4(with)-301.9(TBI)-305.9(compared)]TJ
0 -1.2974 TD
[(with)-307.6(the)-304.7(control)-306.7(gro)-7.6(up.)-304.7(Graph)-302.3(sho)-8.6(ws)-298.6(d)-7.1(istributio)-12.5(n)]TJ
0 -1.3031 TD
[(of)-306.1(the)-299(d)-7.1(ata)-302(with)-301.9(the)-304.7(media)-8.9(n)-301.6(indicate)-8.9(d)-297.3(b)0(y)-307.3(the)]TJ
0 -1.2974 TD
[(hor)-7.6(izontal)-305.2(bars)-307.7(\(control,)]TJ
/F7 1 Tf
10.317 0 TD
(n)Tj
/F8 1 Tf
.6999 0 TD
(=)Tj
/F6 1 Tf
.717 0 TD
[(7;)-305.9(TBI,)]TJ
/F7 1 Tf
2.7713 0 TD
(n)Tj
/F8 1 Tf
.6999 0 TD
(=)Tj
/F6 1 Tf
.717 0 TD
(14;)Tj
-15.9222 -1.2974 TD
(**)Tj
/F7 1 Tf
.8137 0 TD
(p)Tj
/F8 1 Tf
.6886 0 TD
(<)Tj
/F6 1 Tf
.7227 0 TD
[(0.01\).)-304.5(CS)-8.8(F,)-297.1(cerebr)-10.1(ospi)-8.6(nal)-299.2(ui)-7.4(d;)-299.4(ELIS)-9.4(A,)]TJ
-2.225 -1.3031 TD
[(enz)-6.2(yme-link)-9.7(ed)-298(immu)-10.9(nosorbent)-310.9(assay)-9(;)-298.1(Shh,)-304.1(son)-8.6(ic)]TJ
0 -1.2974 TD
[(hed)-7.8(gehog;)-304.1(TBI,)-308.1(traumatic)-310.9(brain)-302.9(inju)-9.6(ry.)]TJ
ET
313.058 163.332 239.131 .22676 re
f
313.058 110.891 239.131 .28345 re
f
313.058 145.644 239.131 .22682 re
f
BT
/F4 1 Tf
8.9663 0 0 8.9663 313.0582 169.9653 Tm
[(Table)-306.5(2.)-500.5(Human)-299.6(PCR)]TJ
/F9 1 Tf
7.9702 0 0 7.9702 406.3747 151.8803 Tm
[(Cortex)-9850.7(Hippocamp)9.5(us)]TJ
/F6 1 Tf
-11.7082 -2.1268 TD
[(Shh)-9048.3(10.26)]TJ
/F8 1 Tf
13.0384 0 TD
()Tj
/F6 1 Tf
.7184 0 TD
[(1.46)-9483.3(9.33)]TJ
/F8 1 Tf
13.1024 0 TD
()Tj
/F6 1 Tf
.7113 0 TD
(1.29)Tj
-27.5705 -1.1239 TD
[(Smo)-9290.4(9.90)]TJ
/F8 1 Tf
13.0384 0 TD
()Tj
/F6 1 Tf
.7184 0 TD
[(1.44)-9483.3(9.20)]TJ
/F8 1 Tf
13.1024 0 TD
()Tj
/F6 1 Tf
.7113 0 TD
(1.42)Tj
-27.5705 -1.1239 TD
[(Ptc)-9853.4(9.63)]TJ
/F8 1 Tf
13.0384 0 TD
()Tj
/F6 1 Tf
.7184 0 TD
[(0.68)-9483.3(9.30)]TJ
/F8 1 Tf
13.1024 0 TD
()Tj
/F6 1 Tf
.7113 0 TD
(0.44)Tj
-26.4395 -2.2477 TD
[(Relative)-301.8(expression)-304.7(of)-306.1(Shh,)-308.4(Smo,)-308.7(and)-306.2(Ptc)-314.7(in)-307.3(cortex)-305.1(\()]TJ
/F7 1 Tf
21.7164 0 TD
(n)Tj
/F8 1 Tf
.6971 0 TD
(=)Tj
/F6 1 Tf
.7113 0 TD
[(5\))-311.5(and)-306.2(hippo-)]TJ
-24.2558 -1.1239 TD
[(campus)-242.7(\()]TJ
/F7 1 Tf
3.7771 0 TD
(n)Tj
/F8 1 Tf
.6971 0 TD
(=)Tj
/F6 1 Tf
.7184 0 TD
[(3\))-240.4(from)-246.5(adult)-235.7(human)-243.9(brain.)-241.1(Expression)-230.4(of)-249.2(all)-243.8(three)-236.7(genes)-239.6(oc-)]TJ
-5.1926 -1.1239 TD
[(curs)-300.9(in)-300.2(both)-292.1(brain)-295.8(regions,)-297(with)-294.8(no)-301.2(signicant)-289.7(difference)-294.4(observed)12.8(.)]TJ
1.131 -1.1239 TD
[(PCR,)-352.7(polymeras)11.3(e)-360.7(chain)-351.5(reaction;)-351.7(Ptc,)-359.5(Patched;)-350.7(Shh,)-351.1(sonic)-354.1(hedgehog;)]TJ
-1.131 -1.131 TD
[(Smo,)-301.6(Smoothen)12.3(ed.)]TJ
/F7 1 Tf
-31.497 86.8229 TD
[(Pringle)-298.4(et)-293.7(al.;)-304.2(Neurotr)10.7(auma)-298.3(Reports)]TJ
/F6 1 Tf
14.5464 0 TD
[(2021,)-295.3(2.1)]TJ
-14.5464 -1.2021 TD
[(http://onl)9.4(ine.liebertpu)9.7(b.com/doi/1)9.2(0.1089/neur.2)11.5(020.0016)]TJ
60.483 1.2021 TD
(30)Tj
ET
/EmbeddedDocument /MC11 BDC
/Document /MC12 BDC
q
572.031 35.263 10.035 -19.162 re
W n
1 .64 .53 .47 k
q 1 0 0 1 572.031 16.06 cm 0 0 m
.966 3.153 1.461 4.22 v
1.739 4.818 2.425 6.378 3.087 7.332 c
3.497 7.924 4.368 8.916 4.541 9.195 c
4.633 9.338 4.701 9.556 y
4.901 9.641 5.09 9.748 v
5.279 9.855 5.638 10.053 5.702 10.239 c
5.807 10.549 5.997 10.624 y
6.187 10.665 6.271 10.678 v
6.44 10.699 6.566 10.772 6.735 10.858 c
6.904 10.945 7.12 11.061 7.516 11.253 c
7.799 11.391 10.08 12.245 y
10.048 12.161 9.858 12.011 v
9.667 11.862 9.25 11.707 9.083 11.621 c
8.914 11.536 7.475 10.816 7.199 10.645 c
6.926 10.474 6.091 9.925 5.47 9.365 c
5.02 8.959 4.51 8.356 4.184 7.914 c
3.263 6.665 2.748 5.394 y
3.551 5.415 3.613 5.415 v
3.676 5.415 3.845 4.924 y
3.212 5.01 2.938 4.861 v
2.663 4.712 2.592 4.659 2.358 4.273 c
2.129 3.895 1.618 2.108 1.314 1.137 c
1.22 .833 1.125 .399 .936 .305 c
.813 .243 0 0 y
f
Q
Q
1 .64 .53 .47 K
1 J 0 j .405 w 4 M []0 d
/GS2 gs
q 1 0 0 1 577.63 22.437 cm 0 0 m
.403 .006 .637 -.007 v
.776 -.013 .996 -.05 1.152 -.097 c
1.288 -.142 1.451 -.222 1.542 -.287 c
1.659 -.373 1.711 -.47 1.783 -.568 c
1.832 -.637 1.991 -1.045 2.063 -1.095 c
2.136 -1.142 2.146 -1.179 2.081 -1.223 c
2.03 -1.257 2.004 -1.324 1.984 -1.373 c
1.965 -1.424 1.89 -1.613 1.84 -1.767 c
1.802 -1.888 1.742 -1.958 1.704 -2.004 c
1.646 -2.071 1.529 -2.169 1.405 -2.236 c
1.312 -2.285 1.146 -2.357 .995 -2.389 c
.716 -2.45 .292 -2.479 .174 -2.469 c
S
Q
1 .64 .53 .47 k
q 1 0 0 1 576.761 19.775 cm 0 0 m
-.054 0 -.095 .02 -.095 .045 c
-.095 .068 -.054 .088 0 .088 c
.05 .088 .094 .068 .094 .045 c
.094 .02 .05 0 0 0 c
-.35 .372 m
-.35 .416 -.271 .451 -.175 .451 c
-.08 .451 0 .416 0 .372 c
0 .328 -.08 .292 -.175 .292 c
-.271 .292 -.35 .328 -.35 .372 c
-.46 .766 m
-.46 .826 -.36 .874 -.238 .874 c
-.116 .874 -.018 .826 -.018 .766 c
-.018 .705 -.116 .656 -.238 .656 c
-.36 .656 -.46 .705 -.46 .766 c
-.586 1.181 m
-.586 1.262 -.477 1.325 -.34 1.325 c
-.206 1.325 -.095 1.262 -.095 1.181 c
-.095 1.101 -.206 1.035 -.34 1.035 c
-.477 1.035 -.586 1.101 -.586 1.181 c
-.19 1.641 m
-.19 1.586 -.269 1.545 -.364 1.545 c
-.462 1.545 -.539 1.586 -.539 1.641 c
-.539 1.69 -.462 1.732 -.364 1.732 c
-.269 1.732 -.19 1.69 -.19 1.641 c
-.373 2.112 m
-.265 2.112 -.175 2.066 -.175 2.012 c
-.175 1.954 -.265 1.908 -.373 1.908 c
-.481 1.908 -.569 1.954 -.569 2.012 c
-.569 2.066 -.481 2.112 -.373 2.112 c
-.303 2.491 m
-.215 2.491 -.143 2.459 -.143 2.418 c
-.143 2.379 -.215 2.347 -.303 2.347 c
-.39 2.347 -.46 2.379 -.46 2.418 c
-.46 2.459 -.39 2.491 -.303 2.491 c
-.175 2.753 m
-.131 2.753 -.095 2.735 -.095 2.708 c
-.095 2.688 -.131 2.666 -.175 2.666 c
-.22 2.666 -.255 2.688 -.255 2.708 c
-.255 2.735 -.22 2.753 -.175 2.753 c
1.513 .335 m
1.371 .352 1.288 .352 1.196 .352 c
1.101 .352 1.021 .346 .69 .352 c
.478 .354 .535 .471 .729 .496 c
.809 .506 .849 .51 .896 .518 c
.944 .525 .991 .531 1.212 .576 c
1.433 .62 1.308 .699 1.138 .711 c
1.009 .719 .952 .722 .903 .722 c
.824 .722 .78 .724 .569 .738 c
.3 .763 .425 .881 .548 .904 c
.611 .914 .637 .918 .675 .926 c
.715 .935 .738 .941 .984 .977 c
1.229 1.013 1.118 1.098 .976 1.109 c
.833 1.126 .809 1.13 .741 1.134 c
.68 1.137 .642 1.136 .471 1.158 c
.312 1.181 .375 1.266 .461 1.285 c
.547 1.307 .606 1.32 .661 1.321 c
.694 1.324 .723 1.33 .889 1.355 c
1.113 1.388 1.118 1.479 .868 1.512 c
.743 1.529 .723 1.53 .698 1.533 c
.661 1.54 .64 1.545 .44 1.566 c
.251 1.588 .304 1.698 .471 1.72 c
.589 1.734 .658 1.743 .69 1.749 c
.723 1.752 .77 1.752 .929 1.77 c
1.143 1.795 1.156 1.898 .936 1.918 c
.809 1.933 .797 1.93 .745 1.934 c
.715 1.937 .705 1.933 .485 1.953 c
.286 1.97 .358 2.07 .494 2.092 c
.62 2.112 .71 2.128 .802 2.142 c
.833 2.146 .858 2.14 1.131 2.2 c
1.284 2.232 1.25 2.307 1.068 2.315 c
1.002 2.32 .884 2.331 .793 2.339 c
.715 2.347 .666 2.347 .517 2.359 c
.366 2.373 .494 2.484 .548 2.498 c
.604 2.514 .84 2.535 .965 2.543 c
1.094 2.55 1.284 2.556 1.394 2.586 c
1.492 2.614 1.433 2.673 1.338 2.695 c
1.29 2.705 1.261 2.713 1.182 2.728 c
1.101 2.742 1.046 2.745 .965 2.761 c
.872 2.78 .889 2.769 .849 2.789 c
.809 2.814 .759 2.898 y
.729 2.985 .683 2.985 v
.636 2.985 .563 2.987 .421 2.987 c
.28 2.987 .326 2.994 .265 2.994 c
.2 2.994 .112 3.01 .026 3.016 c
-.061 3.024 -.171 3.03 -.227 3.024 c
-.281 3.016 -.358 2.992 -.417 2.959 c
-.504 2.906 -.622 2.777 -.692 2.695 c
-.764 2.614 -.875 2.397 -.915 2.323 c
-.954 2.251 -1.08 1.887 -1.129 1.808 c
-1.175 1.727 -1.302 1.675 y
-1.511 1.573 -1.387 1.54 v
-.964 1.423 -1.325 1.269 y
-1.31 1.172 l
-1.27 1.172 -1.262 1.153 v
-1.254 1.13 -1.129 1.158 -1.024 .874 c
-.977 .742 -.933 .651 -.85 .468 c
-.811 .38 -.677 .053 -.446 -.092 c
-.195 -.252 .012 -.207 .121 -.194 c
.251 -.181 .471 -.128 .581 -.125 c
.723 -.114 .763 -.114 .88 -.107 c
.999 -.099 1.361 -.092 y
.873 0 .778 0 v
.683 0 1.007 .094 1.142 .116 c
1.261 .139 1.378 .168 y
1.418 .184 1.553 .211 v
1.688 .242 1.655 .321 1.513 .335 c
f
Q
0 J
q 1 0 0 1 576.744 25.907 cm 0 0 m
-.066 -.119 -.079 -.096 v
-.122 .003 -.244 .254 -.395 .343 c
-.586 .454 -1.661 .89 -1.821 .965 c
-1.948 1.026 -2.464 1.133 -2.75 1.614 c
-3.04 2.104 -3.099 2.207 -3.229 2.355 c
-3.403 2.553 -3.277 2.712 -3.07 2.738 c
-2.962 2.752 -2.821 2.753 -2.718 2.753 c
-2.656 2.754 -2.654 2.877 -2.658 3.009 c
-2.668 3.222 -2.723 3.28 -2.881 3.41 c
-3.04 3.536 -3.323 3.744 -3.387 3.921 c
-3.451 4.096 -3.373 4.398 -3.53 4.526 c
-3.687 4.656 -4.023 4.897 -4.1 5.244 c
-4.164 5.532 -4.025 5.669 -3.927 5.723 c
-3.772 5.808 -3.609 5.804 -3.482 5.676 c
-3.354 5.549 -3.341 5.389 -3.277 5.311 c
-3.214 5.229 -3.051 5.181 -2.976 5.149 c
-2.875 5.106 -2.769 5.065 -2.643 5.032 c
-2.598 5.021 -2.38 4.925 -2.339 5.021 c
-2.302 5.102 -2.351 5.196 -2.389 5.311 c
-2.47 5.532 -3.008 5.771 -3.07 5.837 c
-3.134 5.899 -3.335 6.063 -3.403 6.377 c
-3.467 6.671 -3.468 6.71 -3.53 6.857 c
-3.637 7.108 -3.585 7.299 -3.552 7.427 c
-3.51 7.591 -3.627 7.705 -3.547 7.8 c
-3.446 7.916 -3.299 7.981 -3.198 7.911 c
-3.122 7.856 -3.023 7.773 -2.96 7.726 c
-2.895 7.676 -2.854 7.64 -2.707 7.554 c
-2.596 7.489 -2.439 7.54 -2.327 7.512 c
-2.242 7.489 -2.082 7.349 -2.074 7.364 c
-2.025 7.443 -2.058 7.561 -2.074 7.688 c
-2.09 7.814 -2.216 8.07 -2.247 8.151 c
-2.28 8.23 -2.31 8.359 -2.231 8.469 c
-2.153 8.582 -1.963 8.82 -1.868 8.932 c
-1.773 9.045 -1.661 9.284 -1.504 9.061 c
-1.344 8.836 -1.282 8.694 -1.202 8.646 c
-1.124 8.597 -1.039 8.597 -.917 8.63 c
-.799 8.661 -.646 8.694 -.537 8.726 c
-.426 8.755 -.346 8.836 -.252 8.902 c
-.157 8.965 -.093 8.98 -.03 8.948 c
.033 8.917 .059 8.874 .097 8.789 c
.122 8.729 .122 8.63 .144 8.55 c
.184 8.396 .229 8.322 .207 8.263 c
.159 8.129 .065 8.024 .033 7.927 c
0 7.831 .059 7.567 .018 7.496 c
-.046 7.383 -.109 7.352 -.141 7.239 c
-.173 7.13 -.141 7.001 -.093 6.905 c
-.046 6.811 -.046 6.714 -.03 6.634 c
-.014 6.554 .082 6.603 .144 6.681 c
.207 6.762 .207 6.841 .271 6.953 c
.334 7.064 .491 7.064 .635 7.082 c
.764 7.095 .925 7.258 1.063 7.273 c
1.141 7.281 1.285 7.242 1.348 7.13 c
1.442 6.957 1.458 6.793 1.378 6.664 c
1.3 6.539 1.18 6.429 1.143 6.282 c
1.094 6.097 1.074 5.872 .968 5.723 c
.866 5.581 .727 5.501 .635 5.358 c
.533 5.191 .508 4.877 .555 4.718 c
.604 4.558 .661 4.602 .698 4.687 c
.746 4.795 .787 4.904 .888 4.957 c
1.086 5.061 1.327 5.17 1.475 5.181 c
1.554 5.186 1.712 5.102 1.775 4.973 c
1.839 4.846 1.816 4.657 1.79 4.526 c
1.737 4.276 1.671 4.01 1.602 3.921 c
1.505 3.796 1.391 3.694 1.237 3.584 c
1.08 3.473 .715 3.298 .57 3.201 c
.407 3.091 .323 2.923 .292 2.797 c
.261 2.673 .302 2.578 .382 2.578 c
.46 2.578 .555 2.721 .604 2.785 c
.65 2.851 .705 2.992 .798 3.009 c
.904 3.03 1.031 2.963 1.143 2.963 c
1.253 2.963 1.316 3.009 1.442 3.042 c
1.569 3.073 1.649 2.999 1.632 2.871 c
1.616 2.744 1.616 2.674 1.553 2.593 c
1.49 2.513 1.316 2.419 1.3 2.307 c
1.284 2.194 1.318 2.064 1.3 1.972 c
1.273 1.838 1.143 1.747 1.016 1.635 c
.888 1.525 .46 1.179 .367 .981 c
.3 .844 .3 .566 .318 .454 c
.345 .294 .398 .262 y
.431 .262 .132 .139 .121 .127 c
.047 .055 0 0 y
h
S 1 0 0 1 1.403 6.747 cm 0 0 m
.079 .046 .119 .094 .222 .199 c
.324 .301 .436 .422 .505 .501 c
.559 .56 .696 .684 .768 .806 c
.828 .905 .87 .941 .95 .949 c
.997 .953 1.107 .949 1.164 .972 c
1.22 .996 1.367 1.077 1.417 1.115 c
1.456 1.149 1.679 1.195 1.728 1.021 c
1.777 .829 1.784 .588 1.757 .526 c
1.693 .374 1.6 .262 1.552 .11 c
1.522 .022 1.527 -.153 1.583 -.312 c
1.633 -.459 1.703 -.393 1.798 -.337 c
1.893 -.281 1.964 -.25 2.041 -.258 c
2.121 -.266 2.462 -.312 2.51 -.322 c
2.556 -.328 2.636 -.37 2.612 -.449 c
2.589 -.527 2.431 -.817 2.312 -.92 c
2.192 -1.024 2.105 -1.111 2.083 -1.175 c
2.058 -1.238 1.995 -1.406 1.985 -1.487 c
1.979 -1.566 1.853 -1.718 1.78 -1.765 c
1.709 -1.812 1.393 -2.014 1.346 -2.054 c
1.299 -2.091 1.11 -2.161 1.274 -2.349 c
1.393 -2.484 1.4 -2.421 1.456 -2.413 c
1.513 -2.403 1.545 -2.391 1.646 -2.324 c
1.757 -2.254 1.86 -2.229 1.972 -2.277 c
2.083 -2.324 2.163 -2.357 2.192 -2.403 c
2.257 -2.499 2.202 -2.581 2.176 -2.62 c
2.146 -2.671 1.868 -2.946 1.813 -3.003 c
1.757 -3.059 1.527 -3.259 1.456 -3.315 c
1.387 -3.371 1.22 -3.529 1.171 -3.633 c
1.124 -3.738 1.068 -3.953 1.021 -4.034 c
.974 -4.113 .775 -4.295 .607 -4.407 c
.442 -4.52 .135 -4.736 .071 -4.847 c
.027 -4.922 -.008 -5.127 -.025 -5.288 c
-.04 -5.446 0 -5.589 y
-.119 -5.614 -.205 -5.638 v
-.294 -5.662 -.364 -5.741 -.364 -5.798 c
-.364 -5.853 -.491 -5.988 y
-.477 -5.853 -.554 -5.766 v
-.634 -5.676 -.713 -5.567 -.761 -5.542 c
S
Q
q 1 0 0 1 576.579 25.908 cm 0 0 m
.054 .175 l
-.08 .388 -.135 .459 v
-.19 .531 -.809 1.001 -.901 1.074 c
-.995 1.145 -1.305 1.351 -1.409 1.39 c
-2.032 1.677 -2.075 1.693 v
-2.12 1.712 -2.419 1.883 -2.468 1.909 c
-2.517 1.936 -2.639 2.005 -2.678 2.031 c
-2.715 2.059 -2.748 2.122 -2.748 2.148 c
-2.748 2.176 -2.731 2.227 -2.71 2.221 c
-2.687 2.216 -2.639 2.221 -2.616 2.197 c
-2.596 2.176 -2.507 2.138 -2.456 2.109 c
-2.406 2.081 -2.037 1.901 -1.993 1.879 c
-1.949 1.854 -1.623 1.689 -1.574 1.671 c
-1.523 1.654 -1.294 1.545 -1.255 1.522 c
-1.217 1.501 -1.133 1.445 -1.077 1.418 c
-1.021 1.39 -.901 1.316 -.873 1.297 c
-.848 1.272 -.72 1.179 -.692 1.145 c
-.664 1.114 -.477 .996 -.454 .978 c
-.433 .964 -.301 .836 -.278 .825 c
-.257 .813 -.18 .759 -.162 .754 c
-.146 .747 -.112 .729 -.092 .74 c
-.067 .754 -.057 .818 -.063 .852 c
-.067 .886 -.162 1.346 -.18 1.424 c
-.194 1.501 -.262 1.833 -.278 1.888 c
-.296 1.942 -.41 2.109 -.516 2.187 c
-.619 2.266 -1.105 2.664 -1.166 2.702 c
-1.227 2.739 -1.508 2.946 -1.585 2.984 c
-1.663 3.024 -1.91 3.179 -1.977 3.223 c
-2.044 3.268 -2.374 3.495 -2.43 3.545 c
-2.484 3.594 -2.864 4.004 -2.936 4.082 c
-3.009 4.16 -3.274 4.55 -3.332 4.646 c
-3.393 4.747 -3.538 4.891 -3.603 4.974 c
-3.671 5.057 -3.734 5.167 -3.741 5.207 c
-3.746 5.247 -3.696 5.334 -3.603 5.258 c
-3.511 5.179 -3.454 5.124 -3.399 5.086 c
-3.344 5.046 -3.3 5.003 -3.262 4.945 c
-3.224 4.891 -3.151 4.796 -3.123 4.753 c
-3.096 4.708 -2.97 4.515 -2.926 4.454 c
-2.883 4.392 -2.706 4.136 -2.605 4.022 c
-2.507 3.903 -2.253 3.635 -1.784 3.351 c
-1.317 3.068 -.757 2.691 -.697 2.658 c
-.637 2.623 -.592 2.576 -.554 2.576 c
-.516 2.576 -.498 2.598 -.487 2.623 c
-.477 2.652 -.521 2.758 -.544 2.829 c
-.565 2.901 -.603 3.279 -.626 3.383 c
-.648 3.488 -.823 4.42 -.848 4.499 c
-.867 4.575 -.852 4.715 -1.001 4.806 c
-1.148 4.902 -1.547 5.194 -1.618 5.252 c
-1.69 5.306 -2.264 5.859 -2.324 5.927 c
-2.386 5.992 -2.673 6.332 -2.721 6.38 c
-2.771 6.432 -2.941 6.636 -2.981 6.741 c
-3.018 6.846 -3.047 6.912 -3.079 6.99 c
-3.113 7.068 -3.185 7.234 -3.206 7.283 c
-3.228 7.335 -3.25 7.416 -3.245 7.434 c
-3.239 7.45 -3.218 7.473 -3.175 7.45 c
-3.129 7.428 -3.024 7.29 -3.004 7.251 c
-2.981 7.213 -2.876 7.046 -2.858 7.002 c
-2.843 6.958 -2.803 6.868 -2.776 6.823 c
-2.748 6.781 -2.534 6.476 -2.462 6.402 c
-2.391 6.332 -2.147 6.07 -2.087 6.016 c
-2.027 5.961 -1.518 5.449 -1.435 5.379 c
-1.353 5.306 -1.188 5.2 -1.144 5.184 c
-1.101 5.167 -1.057 5.167 -1.035 5.179 c
-1.011 5.189 -.984 5.222 -.99 5.322 c
-.995 5.423 -1.105 6.353 -1.128 6.486 c
-1.148 6.621 -1.271 7.022 -1.3 7.135 c
-1.325 7.245 -1.364 7.571 -1.392 7.794 c
-1.419 8.016 -1.568 8.645 -1.613 8.737 c
-1.657 8.824 -1.686 8.912 -1.705 8.963 c
-1.728 9.012 -1.767 9.105 -1.739 9.152 c
-1.714 9.195 -1.646 9.339 -1.613 9.334 c
-1.579 9.329 -1.534 9.31 -1.514 9.272 c
-1.491 9.233 -1.446 8.984 -1.435 8.935 c
-1.426 8.884 -1.31 8.337 -1.305 8.293 c
-1.3 8.247 -1.242 8.098 -1.232 8.038 c
-1.223 7.976 -1.184 7.728 -1.178 7.622 c
-1.172 7.517 -1.139 7.406 -1.111 7.385 c
-1.083 7.361 -1.05 7.367 -1.018 7.379 c
-.984 7.389 -.945 7.522 -.911 7.583 c
-.88 7.643 -.71 7.905 -.671 7.947 c
-.631 7.991 -.537 8.198 -.516 8.237 c
-.493 8.275 -.388 8.48 -.356 8.535 c
-.321 8.592 -.229 8.714 -.2 8.755 c
-.174 8.79 -.129 8.867 -.102 8.863 c
-.074 8.857 -.009 8.824 y
.048 8.784 .014 8.709 v
-.018 8.63 -.14 8.486 -.174 8.432 c
-.207 8.377 -.345 8.128 -.388 8.026 c
-.433 7.928 -.615 7.711 -.644 7.667 c
-.671 7.622 -.775 7.373 -.813 7.283 c
-.852 7.193 -.919 7.018 -.935 6.924 c
-.95 6.83 -.919 6.396 -.906 6.332 c
-.896 6.265 -.79 5.526 -.78 5.395 c
-.769 5.262 -.736 5.057 -.72 4.997 c
-.702 4.935 -.687 4.764 -.676 4.663 c
-.664 4.564 -.659 4.509 -.631 4.481 c
-.603 4.454 -.565 4.447 -.544 4.465 c
-.521 4.481 -.382 4.698 -.349 4.747 c
-.316 4.796 -.169 5.04 -.146 5.067 c
-.123 5.097 .108 5.35 .18 5.407 c
.253 5.461 .394 5.59 .449 5.683 c
.505 5.776 .561 5.882 .621 6.032 c
.681 6.182 .731 6.409 .77 6.47 c
.81 6.529 .896 6.697 .931 6.741 c
.963 6.787 1.14 7.002 1.194 7.033 c
1.25 7.068 1.305 7.117 1.338 7.117 c
1.37 7.117 1.403 7.074 1.397 7.04 c
1.394 7.008 1.338 6.944 1.315 6.92 c
1.296 6.891 1.129 6.691 1.101 6.636 c
1.072 6.581 .913 6.265 .896 6.192 c
.88 6.121 .831 5.91 .798 5.844 c
.764 5.776 .72 5.667 .647 5.566 c
.576 5.467 .466 5.362 .372 5.272 c
.279 5.184 .081 5.029 .004 4.895 c
-.074 4.764 -.339 4.38 -.373 4.277 c
-.406 4.172 -.576 3.938 -.472 3.523 c
-.367 3.107 -.333 3.019 y
-.321 2.901 -.262 2.936 v
-.2 2.968 -.146 3.102 -.097 3.156 c
-.047 3.212 .141 3.434 .19 3.477 c
.24 3.523 .389 3.665 .477 3.738 c
.566 3.811 .852 4.031 .907 4.071 c
.963 4.11 1.167 4.287 1.212 4.337 c
1.255 4.388 1.382 4.582 1.409 4.612 c
1.438 4.646 1.496 4.708 1.531 4.708 c
1.564 4.708 1.619 4.675 1.603 4.612 c
1.586 4.555 1.543 4.475 1.491 4.397 c
1.442 4.321 1.37 4.216 1.338 4.176 c
1.305 4.136 1.194 4.056 1.145 4.009 c
1.095 3.967 .88 3.827 .81 3.761 c
.736 3.695 .652 3.635 .512 3.502 c
.365 3.366 .312 3.323 .229 3.223 c
.147 3.125 0 2.885 -.041 2.792 c
-.08 2.696 -.135 2.498 -.135 2.427 c
-.135 2.353 -.097 2.031 -.063 1.883 c
-.03 1.732 -.03 1.599 .014 1.549 c
.059 1.501 .091 1.506 .118 1.527 c
.147 1.549 .168 1.645 .208 1.693 c
.246 1.743 .284 1.788 .322 1.833 c
.362 1.879 .5 1.993 .543 2.026 c
.587 2.059 .692 2.148 .746 2.187 c
.804 2.227 .958 2.387 1.013 2.42 c
1.067 2.455 1.15 2.514 1.188 2.52 c
1.229 2.524 1.319 2.547 1.343 2.542 c
1.366 2.538 1.426 2.504 1.388 2.458 c
1.349 2.414 1.217 2.298 1.188 2.275 c
1.161 2.254 1.007 2.122 .936 2.059 c
.862 1.999 .72 1.904 .665 1.86 c
.61 1.816 .517 1.727 .472 1.671 c
.429 1.615 .362 1.506 .328 1.424 c
.295 1.339 .246 1.114 .229 .99 c
.212 .867 .24 .724 .253 .687 c
.263 .646 .267 .609 .279 .575 c
.29 .543 .345 .452 .365 .569 c
.389 .687 .417 .874 .477 .946 c
.537 1.02 .715 1.25 .731 1.095 c
.746 .94 .556 .598 .569 .475 c
.587 .354 .551 .192 .482 .092 c
.417 -.007 .196 -.072 .158 -.067 c
.118 -.062 0 0 y
f
Q
q 1 0 0 1 578.21 27.082 cm 0 0 m
.164 .542 .176 .587 v
.188 .631 .131 .741 .121 .775 c
.109 .81 .054 .932 .054 .984 c
.054 1.042 .065 1.107 .109 1.13 c
.153 1.153 .176 1.175 .231 1.239 c
.285 1.308 .341 1.363 .351 1.462 c
.363 1.561 .351 1.596 .386 1.673 c
.418 1.75 .462 1.817 .551 1.872 c
.638 1.928 .693 1.993 .772 2.037 c
.849 2.081 .926 2.172 .98 2.228 c
1.036 2.282 1.148 2.393 1.213 2.427 c
1.279 2.461 1.345 2.482 1.411 2.491 c
1.476 2.505 1.521 2.516 1.599 2.537 c
1.676 2.56 1.753 2.659 1.775 2.692 c
1.797 2.726 1.786 2.825 1.664 2.78 c
1.543 2.735 1.366 2.692 1.313 2.682 c
1.256 2.669 1.114 2.637 1.07 2.592 c
1.025 2.549 .97 2.461 .849 2.383 c
.728 2.304 .65 2.206 .584 2.206 c
.517 2.206 .484 2.206 .508 2.315 c
.529 2.427 .54 2.592 .574 2.726 c
.606 2.857 .65 3.058 .672 3.157 c
.693 3.259 .737 3.445 .804 3.469 c
.87 3.489 .991 3.545 1.091 3.645 c
1.19 3.744 1.323 3.866 1.4 3.954 c
1.476 4.042 1.599 4.276 1.664 4.331 c
1.73 4.388 1.84 4.509 1.952 4.553 c
2.062 4.598 1.996 4.589 2.161 4.62 c
2.326 4.653 2.37 4.644 2.437 4.686 c
2.503 4.731 2.548 4.775 2.514 4.786 c
2.481 4.797 2.481 4.797 2.415 4.831 c
2.349 4.863 2.293 4.907 2.216 4.887 c
2.14 4.863 2.05 4.843 1.974 4.809 c
1.897 4.775 1.709 4.696 1.653 4.62 c
1.599 4.542 1.433 4.366 1.378 4.299 c
1.323 4.233 1.224 4.11 1.179 4.057 c
1.134 3.999 1.08 3.945 1.025 3.912 c
.97 3.878 .837 3.844 .87 3.978 c
.904 4.11 .915 4.255 .949 4.398 c
.98 4.542 1.014 4.809 1.091 4.887 c
1.168 4.965 1.289 5.098 1.345 5.151 c
1.4 5.206 1.476 5.328 1.378 5.317 c
1.279 5.307 1.224 5.417 1.235 5.496 c
1.245 5.574 1.279 5.827 1.313 5.938 c
1.345 6.05 1.423 6.248 1.456 6.315 c
1.488 6.381 1.5 6.436 1.588 6.525 c
1.676 6.615 1.808 6.647 1.719 6.727 c
1.631 6.803 1.313 6.959 1.411 6.925 c
1.51 6.892 1.4 6.77 1.389 6.727 c
1.378 6.682 1.323 6.626 1.289 6.525 c
1.256 6.427 1.19 6.283 1.168 6.183 c
1.148 6.082 1.058 5.807 1.047 5.672 c
1.036 5.539 .991 5.496 .991 5.45 c
.991 5.406 .915 5.328 .86 5.429 c
.804 5.528 .804 5.607 .782 5.695 c
.76 5.783 .772 5.871 .76 5.928 c
.75 5.982 .617 6.082 .617 5.938 c
.617 5.794 .606 5.761 .617 5.695 c
.627 5.628 .627 5.561 .638 5.474 c
.65 5.385 .716 5.131 .75 5.074 c
.782 5.019 .849 4.887 .826 4.775 c
.804 4.664 .75 4.589 .728 4.509 c
.704 4.434 .661 4.276 .508 4.441 c
.351 4.609 -.065 5.273 -.1 5.317 c
-.134 5.363 -.177 5.395 -.221 5.284 c
-.265 5.175 -.299 5.295 -.211 5.141 c
-.123 4.986 -.033 4.852 .021 4.731 c
.076 4.609 .176 4.498 .231 4.419 c
.285 4.344 .351 4.276 .407 4.188 c
.462 4.1 .484 4.089 .473 3.889 c
.462 3.689 .407 3.29 .351 2.914 c
.297 2.537 .231 2.206 .176 2.116 c
.121 2.027 .109 1.982 0 2.072 c
-.111 2.16 -.078 2.26 -.123 2.304 c
-.167 2.351 -.243 2.404 -.32 2.36 c
-.397 2.315 -.541 2.238 -.53 2.172 c
-.519 2.105 -.608 2.126 -.464 2.072 c
-.32 2.016 -.299 2.006 -.265 1.95 c
-.233 1.895 -.221 1.883 -.177 1.829 c
-.134 1.772 -.1 1.807 -.012 1.772 c
.076 1.739 .099 1.783 .131 1.693 c
.164 1.607 .241 1.65 .164 1.484 c
.087 1.318 -.055 1.283 -.111 1.153 c
-.167 1.02 -.155 .942 -.155 .842 c
-.155 .741 -.167 .676 -.221 .566 c
-.276 .453 -.199 .532 -.403 .343 c
-.608 .155 -.795 .044 -.815 -.057 c
-.838 -.154 -.905 -.2 -.838 -.243 c
-.772 -.288 -.739 -.255 -.696 -.345 c
-.649 -.433 -.597 -.441 -.597 -.531 c
-.597 -.619 -.331 -.401 y
0 0 l
f
Q
EMC
EMC
endstream
endobj
72 0 obj
<>stream
Adobe d C
s !1AQa"q2B#R3b$r%C4Scs5D'6Tdt&
EFVU(eufv7GWgw8HXhx)9IYiy*:JZjz ? Nlٳao5k#A&-"i"fHc>#/;XMx4U( *ǏDμ 3yxeǏ@X
7JIQւpRxM_
{4\Mм{
Z+[v=_JVr+SΞjJn\ҼnB