COVID-19: molecular pathophysiology, genetic evolution and prospective therapeutics—a review

Dhanya Raj, C. T., Kandaswamy, Dinesh Kumar, Reddy Danduga, Ravi Chandra Sekhara, Rajasbapathy, Raju and James, Rathinam Arthur 2021. COVID-19: molecular pathophysiology, genetic evolution and prospective therapeutics—a review. Archives of Microbiology 203 , pp. 2043-2057. 10.1007/s00203-021-02183-z

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Abstract

The Covid-19 pandemic is highly contagious and has spread rapidly across the globe. To date there have been no specific treatment options available for this life-threatening disease. During this medical emergency, target-based drug repositioning/repurposing with a continuous monitoring and recording of results is an effective method for the treatment and drug discovery. This review summarizes the recent findings on COVID-19, its genomic organization, molecular evolution through phylogenetic analysis and has recapitulated the drug targets by analyzing the viral molecular machinery as drug targets and repurposing of most frequently used drugs worldwide and their therapeutic applications in COVID-19. Data from solidarity trials have shown that the treatment with Chloroquine, hydroxychloroquine and lopinavir-ritonavir had no effect in reducing the mortality rate and also had adverse side effects. Remdesivir, Favipiravir and Ribavirin might be a safer therapeutic option for COVID-19. Recent clinical trial has revealed that dexamethasone and convalescent plasma treatment can reduce mortality in patients with severe forms of COVID-19.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences
Subjects:	Q Science > QR Microbiology Q Science > QR Microbiology > QR355 Virology R Medicine > R Medicine (General)
Additional Information:	This article is licensed under a Creative Commons Attribution 4.0 International License
Publisher:	Springer Verlag
ISSN:	0302-8933
Date of First Compliant Deposit:	8 February 2021
Date of Acceptance:	27 December 2020
Last Modified:	05 May 2023 20:05
URI:	https://orca.cardiff.ac.uk/id/eprint/138372

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