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Exact group sequential designs for two-arm experiments with Poisson distributed outcome variables

Grayling, Michael J., Wason, James M. S. and Mander, Adrian P. 2019. Exact group sequential designs for two-arm experiments with Poisson distributed outcome variables. Communications in Statistics - Theory and Methods 50 (1) , pp. 18-34. 10.1080/03610926.2019.1628273

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Abstract

We describe and compare two methods for the group sequential design of two-arm experiments with Poisson distributed data, which are based on a normal approximation and exact calculations respectively. A framework to determine near-optimal stopping boundaries is also presented. Using this framework, for a considered example, we demonstrate that a group sequential design could reduce the expected sample size under the null hypothesis by as much as 44% compared to a fixed sample approach. We conclude with a discussion of the advantages and disadvantages of the two presented procedures.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Centre for Trials Research (CNTRR)
Publisher: Taylor & Francis
ISSN: 0361-0926
Date of First Compliant Deposit: 29 April 2021
Date of Acceptance: 31 May 2019
Last Modified: 29 Apr 2021 15:15
URI: http://orca.cardiff.ac.uk/id/eprint/140821

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