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Maternal obesity and developmental programming of neuropsychiatric disorders: an inflammatory hypothesis

Davis, Jonathan and Mire, Erik 2021. Maternal obesity and developmental programming of neuropsychiatric disorders: an inflammatory hypothesis. Brain and Neuroscience Advances 5 , pp. 1-12. 10.1177/23982128211003484

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Abstract

Maternal obesity is associated with the development of a variety of neuropsychiatric disorders; however, the mechanisms behind this association are not fully understood. Comparison between maternal immune activation and maternal obesity reveals similarities in associated impairments and maternal cytokine profile. Here, we present a summary of recent evidence describing how inflammatory processes contribute towards the development of neuropsychiatric disorders in the offspring of obese mothers. This includes discussion on how maternal cytokine levels, fatty acids and placental inflammation may interact with foetal neurodevelopment through changes to microglial behaviour and epigenetic modification. We also propose an exosome-mediated mechanism for the disruption of brain development under maternal obesity and discuss potential intervention strategies.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher: SAGE Publications
ISSN: 2398-2128
Date of First Compliant Deposit: 19 May 2021
Date of Acceptance: 9 February 2021
Last Modified: 20 May 2021 13:45
URI: http://orca.cardiff.ac.uk/id/eprint/141460

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