Medical algorithm: diagnosis and management of antibody immunodeficiencies

Sedivá, Anna, Milota, Tomás, Litzman, Jirí, Quinti, Isabella, Meyts, Isabelle, Burns, Siobhan and Jolles, Stephen 2021. Medical algorithm: diagnosis and management of antibody immunodeficiencies. Allergy 76 (12) , pp. 3841-3844. 10.1111/all.14961

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Abstract

Primary antibodydeficiencies (PAD) constitute the majority of all primary immunodeficiency diseases (PID) also termed in born errors of immunity (IEI). This category (PAD) representsaround 52% of all IEI and the proportion overall is still greater given that antibody deficiency is a component of other groups including combined and severe combined immunodeficiencies (SCID), autoinflammatory disorders, diseases of immune dysregulation and other well defined PIDs(1,2). Secondary antibody deficiencies (SAD) represent a larger and expanding number of individuals resulting from the use of a wide range of immunosuppressive therapies, in particular those targeting B cells, and may also result from renal orgastrointestinal immunoglobulin losses, infections, for example HIVormalaria,malnutritionorothers(3).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	John Wiley and Sons
ISSN:	0105-4538
Date of First Compliant Deposit:	2 June 2021
Date of Acceptance:	12 May 2021
Last Modified:	15 Nov 2023 14:53
URI:	https://orca.cardiff.ac.uk/id/eprint/141664

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