Through-thickness plasma modification of biodegradable and nonbiodegradable porous polymer constructs

Safinia, Laleh, Wilson, Karen, Mantalaris, Athanasios and Bismarck, Alexander 2008. Through-thickness plasma modification of biodegradable and nonbiodegradable porous polymer constructs. Journal of Biomedical Materials Research Part A 87A (3) , pp. 632-642. 10.1002/jbm.a.31731

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Abstract

Pure poly(lactide-co-glycolide) and polystyrene surfaces are not very suitable to support cell adhesion/spreading owing to their hydrophobic nature and low surface energy. The interior surfaces of large porous 3D scaffolds were modified and activated using radio-frequency, low-pressure air plasma. An increase in the wettability of the surface was observed after exposure to air plasma, as indicated by the decrease in the contact angles of the wet porous system. The surface composition of the plasma-treated polymers was studied using X-ray photoelectron spectroscopy. pH-dependent zeta-potential measurements confirm the presence of an increased number of functional groups. However, the plasma-treated surfaces have a less acidic character than the original polymer surfaces as seen by a shift in their isoelectric point. Zeta-potential, as well as contact angle measurements, on 3D scaffolds confirm that plasma treatment is a useful tool to modify the surface properties throughout the interior of large scaffolds

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Cardiff Catalysis Institute (CCI)
Subjects:	Q Science > QD Chemistry
Publisher:	Wiley-Liss
ISSN:	15493296
Last Modified:	19 Mar 2016 22:43
URI:	https://orca.cardiff.ac.uk/id/eprint/25367

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