Comparing the effects of selective cingulate cortex and cingulum bundle lesions on a spatial navigation task

Warburton, E. C., Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308 and Muir, Janice L. 1998. Comparing the effects of selective cingulate cortex and cingulum bundle lesions on a spatial navigation task. European Journal of Neuroscience 10 (2) , pp. 622-634. 10.1046/j.1460-9568.1998.00074.x

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Abstract

The ability of rats to learn the location of a hidden platform in a swim maze was compared in animals with excitotoxic lesions of the anterior or posterior (retrosplenial) cingulate cortex or radiofrequency lesions of the cingulum bundle or fimbria-fornix. Performance of this allocentric spatial task was unaffected by the posterior cingulate cortex lesions, while anterior cingulate cortex damage produced only a mild acquisition deficit. Transection of the fornix and lesions of the cingulum bundle produced similar patterns of impairment on initial acquisition, but the cingulum bundle lesions had less effect on reversal of the task. The results from the water maze, and from a subsequent T-maze alternation task, indicate that cingulum bundle lesions can produce a spatial deficit that is similar, but milder, to that observed after fornix transection. The results of the excitotoxic lesions suggest that previous studies examining conventional cingulate lesions may have been influenced by damage to adjacent fibre tracts, such as the cingulum bundle.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	spatial memory; cingulate cortex; cingulum bundle; fornix; rat
Publisher:	Wiley-Blackwell
ISSN:	0953-816X
Last Modified:	21 Oct 2022 08:58
URI:	https://orca.cardiff.ac.uk/id/eprint/34935

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