Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Sexual differentiation of the brain: investigating the role of Sry using animal models

Kopsida, Eleni 2012. Sexual differentiation of the brain: investigating the role of Sry using animal models. PhD Thesis, Cardiff University.
Item availability restricted.

[thumbnail of 2012kopsidaephd.pdf]
Preview
PDF - Accepted Post-Print Version
Download (2MB) | Preview
[thumbnail of kopsidae1.pdf] PDF - Supplemental Material
Restricted to Repository staff only

Download (507kB)

Abstract

Recent findings have challenged the dogma that gonadal hormones are the sole factor mediating sexual differentiation of the mammalian brain, and have highlighted the importance of sex-linked genes in this process, either independently, or in combination with, gonadal hormones. Using two rodent models, this thesis investigated the roles of the Y-linked (male-specific) gene Sry and other sex chromosome-linked genes on emotional behaviour. Using an established murine ‘four core genotype’ (FCG) model an attempt was made to dissociate, ‘Sry-dependent effects’ (due to direct effects of Sry brain expression, or to downstream hormonal factors) and effects due to ‘sex chromosome complement’ (i.e. sex-linked genes other than Sry). The mouse work was augmented by the development of a novel rat Sry antisense ‘knockdown’ model permitting investigation of the behavioural effects of direct manipulation of Sry expressed in discrete brain areas.

Item Type: Thesis (PhD)
Status: Unpublished
Schools: Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Date of First Compliant Deposit: 30 March 2016
Last Modified: 19 Mar 2016 23:02
URI: https://orca.cardiff.ac.uk/id/eprint/36105

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics