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A meta-analysis of the MTHFR C677T polymorphism and schizophrenia risk

Lewis, Sarah J., Zammit, Stanley, Gunnell, David and Smith, George Davey 2005. A meta-analysis of the MTHFR C677T polymorphism and schizophrenia risk. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 135B (1) , pp. 2-4. 10.1002/ajmg.b.30170

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Epigenetic mechanisms such as methylation of DNA, could lead to abnormal neurodevelopment and may be important in the etiology of schizophrenia. Maternal dietary folate intake may play a role in determining methylation levels. The MTHFR gene C677T polymorphism influences folate metabolism and intracellular availability of folate metabolites for methylation. We carried out a meta-analysis of MTHFR C677T genotype and schizophrenia risk, and found that TT homozygotes had a significantly increased risk, OR 1.48 (1.18–1.86). This supports the hypothesis that folate status is a determinant of schizophrenia risk. Larger studies of this issue are required, together with studies of maternal genotype which could identify whether maternal folate status during pregnancy is important. © 2005 Wiley-Liss, Inc.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: MTHFR, schizophrenia, folate, polymorphism
Publisher: Wiley-Blackwell
ISSN: 1552-4841
Related URLs:
Last Modified: 04 Jun 2017 04:47

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