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Is NF-κappaB a useful therapeutic target in rheumatoid arthritis?

Feldman, M, Andreakos, E, Smith, C, Bondeson, Jan, Yoshimura, S, Kiriakidis, S, Monaco, C, Gasparini, C, Sacre, S, Lundberg, A, Paleolog, E, Horwood, N. J., Brennan, F. M. and Foxwell, B. M. J. 2002. Is NF-κappaB a useful therapeutic target in rheumatoid arthritis? Annals of the Rheumatic Diseases 61 , pp. 13-18. 10.1136/ard.61.suppl_2.ii13

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There is increasing evidence that NF-kappaB is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-kappaB might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-kappaB blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-kappaB family.

Item Type: Article
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: BMJ Publishing Group
ISSN: 0003-4967
Last Modified: 30 Jun 2017 03:25

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