Measurement of T1 and T2 in the cervical spinal cord at 3 Tesla

Smith, Seth A., Edden, Richard Anthony Edward, Farrell, Jonathan A. D., Barker, Peter B. and Van Zijl, Peter C. M. 2008. Measurement of T1 and T2 in the cervical spinal cord at 3 Tesla. Magnetic Resonance in Medicine 60 (1) , pp. 213-219. 10.1002/mrm.21596

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Abstract

T1 and T2 were measured for white matter (WM) and gray matter (GM) in the human cervical spinal cord at 3T. T1 values were calculated using an inversion-recovery (IR) and B1-corrected double flip angle gradient echo (GRE) and show significant differences (p = 0.002) between WM (IR = 876 ± 27 ms, GRE = 838 ± 54 ms) and GM (IR = 973 ± 33 ms, GRE = 994 ± 54 ms). IR showed significant difference between lateral and dorsal column WM (863 ± 23 ms and 899 ± 18 ms, respectively, p = 0.01) but GRE did not (p = 0.40). There was no significant difference (p = 0.31) in T2 between WM (73 ± 6 ms) and GM (76 ± 3 ms) or between lateral and dorsal columns (lateral: 73 ± 6 ms, dorsal: 72 ± 7 ms, p = 0.59). WM relaxation times were similar to brain structures with very dense fiber packing (e.g., corpus callosum), while GM values resembled deep GM in brain. Optimized sequence parameters for maximal contrast between WM and GM, and between WM and cerebrospinal fluid (CSF) were derived. Since the spinal cord has rostral-caudal symmetry, we expect these findings to be applicable to the whole cord. Magn Reson Med 60:213–219, 2008. © 2008 Wiley-Liss, Inc.

Item Type:	Article
Status:	Published
Schools:	Chemistry
Uncontrolled Keywords:	relaxation; measurement;s pinal cord; 3 Tesla T1; T2
ISSN:	1522-2594
Last Modified:	10 Oct 2017 13:01
URI:	https://orca.cardiff.ac.uk/id/eprint/6127

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