Gap junctions and connexin-mediated communication in the immune system

Oviedo-Orta, Ernesto and Evans, William 2004. Gap junctions and connexin-mediated communication in the immune system. Biochimica et Biophysica Acta (BBA) - Biomembranes 1662 (1-2) , pp. 102-112. 10.1016/j.bbamem.2003.10.021

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Abstract

Gap junctions and connexins are present in the immune system. In haematopoiesis, connexin 43, the most widely distributed gap junction protein, appears to be a key player in the development of progenitor cells and their communication with stromal cells. Connexin 43 is expressed by macrophages, neutrophils and mast cells. Lymphocytes also express connexin 43, and inhibition of gap junction channels in these cells by using highly specific connexin mimetic reagents has profound effects on immunoglobulin secretion and synthesis of cytokines. Lymphocytes and leukocytes also communicate directly in vitro with endothelial cells via gap junctions. Connexins are implicated in inflammatory reactions in a range of tissues. Their involvement in atherosclerotic plaque formation in the vascular system is also a current growth point in research, and could lead to the development of therapeutic interventions.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Connexin; Inflammation; Lymphocyte; Endothelium; Leukocyte; Monocyte; Macrophage; Mast cell; Intercellular communication.
Publisher:	Elsevier
ISSN:	0005-2736
Last Modified:	17 Mar 2021 02:50
URI:	https://orca.cardiff.ac.uk/id/eprint/65337

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