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Modeling of regional dynamic CO2 reactivity in respiratory related brain areas using BOLD fMRI

Mitsis, G. D., Harvey, Ann, Dirckx, S., Mayhew, S. D., Rogers, R., Tracey, I., Wise, R. G. and Pattinson, K. T. S. 2008. Modeling of regional dynamic CO2 reactivity in respiratory related brain areas using BOLD fMRI. Presented at: 8th IEEE International Conference on BioInformatics and BioEngineering, Athens, Greece, 8-10 October 2008. BioInformatics and BioEngineering, 2008. BIBE 2008. 8th IEEE International Conference on. IEEE, pp. 1-5. 10.1109/BIBE.2008.4696667

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Abstract

The cerebrovascular bed is very sensitive to CO2 changes, particularly the areas responsible for generation and control of respiratory rhythm. We have used BOLD functional magnetic resonance imaging (fMRI) and externally induced CO2 challenges that stimulate respiration, to identify respiratory areas in-vivo in humans and to quantify the dynamic effects of CO2 on the BOLD fMRI signal (dynamic CO2 reactivity). We sought to identify regional differences in dynamic reactivity within the brainstem and other respiratory related areas (thalamus) by using linear impulse response (IR) and nonlinear Volterra models, as well as experimental measurements obtained during spontaneous breathing and larger externally induced step CO2 changes (end-tidal forcing). The results revealed areas in the brainstem and thalamus that responded strongly to the external CO2 stimuli, which correspond to respiratory nuclei identified in recent rodent studies, as well as pronounced regional differences in CO2 reactivity.

Item Type: Conference or Workshop Item (Paper)
Date Type: Publication
Status: Published
Schools: Biosciences
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > QH Natural history > QH301 Biology
T Technology > TA Engineering (General). Civil engineering (General)
Publisher: IEEE
ISBN: 9781424428441
Last Modified: 19 Mar 2016 23:48
URI: https://orca.cardiff.ac.uk/id/eprint/66101

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