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Membrane traffic at the hepatocyte's sinusoidal and canalicular surface domains [review]

Evans, William Howard 1981. Membrane traffic at the hepatocyte's sinusoidal and canalicular surface domains [review]. Hepatology -Baltimore then Orlando- 1 (5) , pp. 452-457. /10.1002/hep.1840010515

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Traffic in the environs of regions of the hepatocyte's plasma membrane is heavy. A fuller understanding of the nature and control of this membrane traffic depends on the appreciation of the hepatocyte's plasma membrane. This conglomerate consists of a receptor-rich and metabolically dynamic blood-sinusoidal domain which is separated from the bile canalicular domain by a lateral domain which participates in cell-cell interactions (1, 2). The rapid receptor-mediated endocytotic uptake and processing of membrane receptor-ligand complexes occurring against a background of hepatic secretion is a key step in understanding relationships between intracellular membrane compartments and the maintenance of differentiated plasma membrane domains. The fate of a wide range of interiorized ligands appears to be decided upon transfer to a Golgi-endoplasmic reticulum lysosomal (GERL) locus where a processing decision is made leading to release of ligands in an intact form into sinusoids or bile canaliculi, or to degradation. This review discusses properties of receptor-binding sites for hormones and metabolites which are located primarily at the sinusoidal plasma membrane, the biogenesis of this membrane, and the various traffic routes of membrane-ligand complexes traversing the hepatocyte interior.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Publisher: Wiley-Blackwell
ISSN: 0270-9139
Last Modified: 17 Mar 2021 02:53

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