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The effect of topical 0.75% metronidazole gel on malodorous cutaneous ulcers

Finlay, Ilora Gillian, Bowszyc, J., Ramlau, C. and Gwiezdzinski, Z. 1996. The effect of topical 0.75% metronidazole gel on malodorous cutaneous ulcers. Journal of Pain and Symptom Management 11 (3) , pp. 158-162. 10.1016/0885-3924(95)00164-6

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The unpleasant smell of infected fungating tumors and benign cutaneous ulcers is a distressing clinical problem, known to be associated with anaerobic infection. Topical metronidazole 0.8% gel has been shown to decrease smell from fungating malodorous tumors. This study was conducted to assess prospectively the subjective and bacteriological response to 0.75% metronidazole gel to decrease smell from these lesions and to assess whether bacterial contamination of the tubes of gel occurs during use. Forty-seven patients with benign or malignant cutaneous lesions associated with a foul smell were assessed for smell, pain, appearance, and bacteriological profile before entry and at 7 and 14 days. Forty-one (95%) of the 43 patients assessed at 14 days reported decreased smell. Anaerobic infection was initially found in 25 (53%) of patients and was eliminated in 21 (84%) of these. At review after 7 days, patients reported less pain from the lesions. Discharge and associated cellulitis were also observed to decrease significantly.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Publisher: Elsevier
ISSN: 0885-3924
Last Modified: 04 Jun 2017 07:47

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