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Effects of oral testosterone undecanoate on growth, body composition, strength and energy expenditure of adolescent boys

Gregory, John Welbourn ORCID: https://orcid.org/0000-0001-5189-3812, Greene, S. A., Thompson, J., Scrimgeour, C. M. and Rennie, M. J. 1992. Effects of oral testosterone undecanoate on growth, body composition, strength and energy expenditure of adolescent boys. Clinical Endocrinology -Oxford- 37 (3) , pp. 207-213. 10.1111/j.1365-2265.1992.tb02312.x

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Abstract

OBJECTIVE: We determined the effect of 3 months of daily, 40 mg oral testosterone undecanoate on growth, body composition, hand grip and quadriceps muscle strength, and total free-living daily energy expenditure in boys with constitutionally delayed puberty. DESIGN: Double blind, placebo controlled study. PATIENTS: Eighteen boys with constitutionally delayed puberty, mean (SD) age 13.2 (1.6) years. MEASUREMENTS: Body composition measurements were made by skinfold thickness, bioelectrical impedance and stable isotope dilution (H2(18)O) methods. Energy expenditure was assessed by the doubly-labelled water (2H2(18)O) technique. RESULTS: Height velocity increased from 5.4 (0.8) to 8.1 (0.6) cm/year (P < 0.05) in the 3 months after active therapy. Fat-free mass increased more with therapy (2.7 (0.3) kg) over the 6-month study period than with placebo (1.7 (0.4) kg, P < 0.5). Height velocity increases correlated with daily increases in fat-free mass (r = 0.68, P = 0.005) in the study group as a whole. Energy expenditure and muscle strength increased similarly in both groups. Predicted adult height decreased in the group which was treated with testosterone undecanoate. CONCLUSIONS: Testosterone undecanoate (40 mg daily for 3 months) significantly increased height velocity and fat-free mass velocities after 6 months but not muscle strength, endurance or total daily energy expenditure.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Publisher: Wiley-Blackwell
ISSN: 0300-0664
Last Modified: 27 Oct 2022 10:24
URI: https://orca.cardiff.ac.uk/id/eprint/69946

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