Influence of platelet size on outcome after myocardial infarction

Martin, J. F., Bath, P. and Burr, Michael Leslie 1991. Influence of platelet size on outcome after myocardial infarction. The Lancet 338 (8780) , pp. 1409-1411. 10.1016/0140-6736(91)92719-i

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Abstract

Although platelet characteristics have an important influence on ischaemic heart disease, the nature of the association of platelet size and platelet count with death and reinfarction after an index heart attack is unknown. Mean platelet volume (MPV), a determinant of platelet reactivity, was measured in 1716 men six months after myocardial infarction (MI). Deaths and recurrent ischaemic heart disease events were then assessed at two years. MPV was greater in 126 men who had a further ischaemic event (fatal or non-fatal) than in the 1590 men who had no further Ml (p<0·001). In addition, the MPV was larger in men who died than in those who did not (p<0·001). There was no difference in platelet count between these groups. When analysed by quartiles, consistent trends of increasing age-adjusted relative odds of death and recurrent ischaemic events were noted for MPV. MPV did not correlate with known ischaemic heart disease risk factors such as blood pressure, blood lipids, fibrinogen, white cell count, or plasma viscosity. We believe that MPV is a further independent risk factor for recurrent Ml.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Publisher:	Elsevier
ISSN:	0140-6736
Last Modified:	04 May 2016 03:20
URI:	https://orca.cardiff.ac.uk/id/eprint/71950

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