Strong association of the Saitohin gene Q7 variant with progressive supranuclear palsy

de Silva, R., Hope, A., Pittman, A., Weale, M.E., Morris, Huw, Wood, N.W. and Lees, A.J. 2003. Strong association of the Saitohin gene Q7 variant with progressive supranuclear palsy. Neurology 61 (3) , pp. 407-409. 10.1212/01.WNL.0000073140.25533.90

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Abstract

Recent reports are inconclusive in showing that the Q7R polymorphism of the novel Saitohin gene, nested in intron 9 of the tau gene, is associated with AD. The authors show that this polymorphism is in complete linkage disequilibrium with the extended tau H1/H2 haplotype and that the Q variant and QQ genotype of Q7R are strongly associated with progressive supranuclear palsy, implicating it as a possibly important pathogenic candidate.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine
Subjects:	R Medicine > R Medicine (General)
ISSN:	0028-3878
Last Modified:	24 Nov 2015 12:00
URI:	https://orca.cardiff.ac.uk/id/eprint/82081

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