Are interleukin-1 gene polymorphisms risk factors or disease modifiers in AD?

Green, Elaine Karen, Harris, J. M., Lemmon, H., Lambert, J. C., Chartier-Harlin, M. C., St. Clair, D., Mann, D. M.A., Iwatsubo, T. and Lendon, C. L. 2002. Are interleukin-1 gene polymorphisms risk factors or disease modifiers in AD? Neurology 58 (10) , pp. 1566-1568. 10.1212/WNL.58.10.1566

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Abstract

Polymorphisms in the interleukin-1 genes, IL-1A and IL-1B, have been associated with AD, but not in all studies. The authors genotyped the IL-1A(-889) and IL-1B(-511) polymorphisms in large independent cohorts of 503 control individuals and 395 patients with AD, and a further 100 with brain Abeta load. No evidence was found of risk for AD with these variants, nor of an effect on age at onset. However, an impact of IL-1B(-511) on Abeta(40) load (p < 0.05) was detected.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Neurology
ISSN:	0028-3878
Last Modified:	09 Sep 2021 15:08
URI:	https://orca.cardiff.ac.uk/id/eprint/82408

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