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Diffusion-MRI in neurodegenerative disorders

Goveas, Joseph, O'Dwyer, Laurence, Mascalchi, Mario, Cosottini, Mirco, Diciotti, Stefano, De Santis, Silvia, Passamonti, Luca, Tessa, Carlo, Toschi, Nicola and Giannelli, Marco 2015. Diffusion-MRI in neurodegenerative disorders. Magnetic Resonance Imaging 33 (7) , pp. 853-876. 10.1016/j.mri.2015.04.006

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The ability to image the whole brain through ever more subtle and specific methods/contrasts has come to play a key role in understanding the basis of brain abnormalities in several diseases. In magnetic resonance imaging (MRI), “diffusion” (i.e. the random, thermally-induced displacements of water molecules over time) represents an extraordinarily sensitive contrast mechanism, and the exquisite structural detail it affords has proven useful in a vast number of clinical as well as research applications. Since diffusion-MRI is a truly quantitative imaging technique, the indices it provides can serve as potential imaging biomarkers which could allow early detection of pathological alterations as well as tracking and possibly predicting subtle changes in follow-up examinations and clinical trials. Accordingly, diffusion-MRI has proven useful in obtaining information to better understand the microstructural changes and neurophysiological mechanisms underlying various neurodegenerative disorders. In this review article, we summarize and explore the main applications, findings, perspectives as well as challenges and future research of diffusion-MRI in various neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease and degenerative ataxias.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Additional Information: Available online 23 April 2015
Publisher: Elsevier
ISSN: 0730-725X
Date of Acceptance: 19 April 2015
Last Modified: 12 Mar 2019 11:46

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