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Enhanced visualization of choroidal vessels using ultrahigh resolution ophthalmic OCT at 1050nm

Považay, Boris, Bizheva, K, Hermann, Boris, Unterhuber, Angelika, Sattmann, Harald, Fercher, Adolf F., Drexler, Wolfgang, Schubert, C., Ahnelt, Peter, Mei, M., Holzwarth, R., Wadsworth, W. J., Knight, J. and Russell, P. St. J. 2003. Enhanced visualization of choroidal vessels using ultrahigh resolution ophthalmic OCT at 1050nm. Optics Express 11 (17) , pp. 1980-1986.

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In this article the ability of ultrahigh resolution ophthalmic optical coherence tomography (OCT) to image small choroidal blood vessels below the highly reflective and absorbing retinal pigment epithelium is demonstrated for the first time. A new light source (?c= 1050 nm, ??? = 165 nm, Pout= 10 mW), based on a photonic crystal fiber pumped by a compact, self-starting Ti:Al2O3 laser has therefore been developed. Ex-vivo ultrahigh resolution OCT images of freshly excised pig retinas acquired with this light source demonstrate enhanced penetration into the choroid and better visualization of choroidal vessels as compared to tomograms acquired with a state-of-the art Ti:Al2O3 laser (Femtolasers Compact Pro, lc= 780 nm, ???= 160 nm, Pout= 400 mW), normally used in clinical studies for in vivo ultrahigh resolution ophthalmic OCT imaging. These results were also compared with retinal tomograms acquired with a novel, spectrally broadened fiber laser (MenloSystems, ?c= 1350 nm, ???= 470 nm, Pout = 4 mW) permitting even greater penetration in the choroid. Due to high water absorption at longer wavelengths retinal OCT imaging at ~1300 nm may find applications in animal ophthalmic studies. Detection and follow-up of choroidal neovascularization improves early diagnosis of many retinal pathologies, e.g. age-related macular degeneration or diabetic retinopathy and can aid development of novel therapy approaches.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Additional Information: Publisher’s copyright requirements: ”This paper was published in [Optics Express] and is made available as an electronic reprint with the permission of OSA. The paper can be found at the]. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law”. See:
ISSN: 10944087
Last Modified: 04 Jun 2017 01:36

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