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Templated chromophore assembly by dynamic covalent bonds

Rocard, Lou, Berezin, Andrey, De Leo, Federica and Bonifazi, Davide 2015. Templated chromophore assembly by dynamic covalent bonds. Angewandte Chemie International Edition 54 (52) , pp. 15739-15743. 10.1002/anie.201507186

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Through the simultaneous use of three orthogonal dynamic covalent reactions, namely disulfide, boronate, and acyl hydrazone formation, we conceived a facile and versatile protocol to spatially organize tailored chromophores, which absorb in the blue, red, and yellow regions, on a preprogrammed α-helix peptide. This approach allowed the assembly of the dyes in the desired ratio and spacing, as dictated by both the relative positioning and distribution of the recognition units on the peptide scaffold. Steady-state UV/Vis absorption and emission studies suggest an energy transfer from the yellow and red donors to the blue acceptor. A molecular dynamics simulation supports the experimental findings that the helical structure is maintained after the assembly and the three dyes are confined in defined conformational spaces.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Wiley
ISSN: 1433-7851
Date of Acceptance: 2 August 2015
Last Modified: 08 Sep 2020 16:00

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