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[(di)14.9(ff)20.9(er)19.7(en)19.7(t)-318(c)0(o)19.7(m)0(b)19.6(i)0(n)20.7(a)0(t)13.8(i)0(o)20.7(n)0(s)-307.3(o)0(f)-307.4(h)0(y)20.8(d)0(r)20.9(o)0(g)20.8(e)0(l)19.5(s)-317.7(an)19.7(d)-317.9(a)0(d)19.7(d)0(i)14.9(t)0(i)20.6(v)0(e)19.7(s)-317.7(ha)19.7(ve)-308.6(be)19.7(en)]TJ
T*
[(st)15.1(ud)20.8(ie)19.5(d)-162.4(a)0(n)19.7(d)-156.6(ma)18.4(ny)-151.9(of)-151.9(th)20.7(em)-148.6(de)19.7(mo)19.6(ns)15.3(tr)20.7(at)19.5(ed)-153.1(pr)20.9(om)19.6(is)20.9(in)15(g)-156.6(r)0(e)19.7(s)0(u)15.3(l)0(t)20.6(s)0(.)]TJ
7.3823 0 0 6.5614 280.7999 400.7621 Tm
-.0162 Tc
[(20)-16.2()8.5(2)-16.2(4)]TJ
9.843 0 0 9.843 59.7543 385.3983 Tm
0 Tc
[(Ho)14.2(we)18.8(ve)19.7(r,)-373.1(th)15(e)-388.2(m)0(a)18.4(i)0(n)-376.7(r)0(e)19.7(a)0(s)19.9(o)0(n)20.8(i)0(n)20.7(g)-387(fo)15.1(r)-387(r)0(e)19.7(s)0(e)19.9(a)0(r)19.7(c)0(h)19.7(,)-389.3(fo)20.9(cu)19.7(si)15.1(ng)-376.6(on)-376.6(hy)20.8(-)]TJ
T*
[(dr)15.1(og)20.8(el)19.5(s)-237(f)0(o)20.9(r)-243(bo)20.8(ne)-228(re)19.7(ge)19.7(ne)19.7(ra)14(ti)20.6(on)20.8(,)-239.6(i)0(s)-226.8(t)0(h)20.7(e)0(i)19.5(r)-243(in)20.7(je)19.6(ct)19.5(ab)19.7(il)20.6(it)14.8(y.)]TJ
7.3823 0 0 6.5614 255.7983 378.8219 Tm
(1)Tj
9.843 0 0 9.843 261.8645 374.4566 Tm
[(Th)19.6(e)-238.4(m)0(a)18.4(i)0(n)]TJ
-20.5334 -1.1116 TD
[(ad)13.9(va)19.7(nt)20.7(ag)19.7(e)-296(o)0(f)-284.4(i)0(n)20.7(j)0(e)19.6(c)0(t)19.6(a)0(b)19.7(l)0(e)-285.7(m)0(a)18.4(t)0(e)13.8(r)0(i)20.7(a)0(l)19.5(s)-294.6(co)19.7(mp)19.6(ar)19.7(ed)-285.6(to)-284.6(3D)-285.3(sc)19.9(af)14(fo)20.9(ld)-284.5(is)]TJ
0 -1.1174 TD
[(th)15(at)-326(th)15(ey)-325.9(ca)18.5(n)-340.9(b)0(e)-331.7(a)0(p)19.7(p)0(l)20.7(i)0(e)19.6(d)-340.9(us)21(in)20.7(g)-340.9(n)0(o)20.8(n)0(i)14.9(n)0(v)20.8(a)0(s)19.9(i)0(v)20.7(e)-342.1(or)-330.5(mi)19.5(ni)20.7(ma)18.4(ll)20.6(y)-340.9(i)0(n)20.7(-)]TJ
0 -1.1116 TD
[(va)13.9(si)20.9(ve)-279.8(su)21(rg)20.9(er)19.7(ie)13.8(s)-288.9(a)0(n)19.7(d)-283.3(th)15(ey)-279.8(ca)18.5(n)-289.1()0(l)20.9(l)-289.2(ir)20.7(re)19.7(gu)20.8(la)19.6(rl)15(y)-283.3(s)0(h)15.3(a)0(p)19.7(e)0(d)-279.8(b)0(o)20.8(n)0(e)-279.8(d)0(e)19.7(-)]TJ
T*
[(fe)14(ct)19.5(s)-191(e)0(a)18.5(s)0(i)15.1(l)0(y)20.7(.)-193.5(Th)19.6(er)19.7(ef)19.7(or)15.1(e,)-184.2(us)21(in)20.7(g)-196.9(a)0(n)-181.9(i)0(n)20.7(j)0(e)19.6(c)0(t)13.8(a)0(b)19.7(l)0(e)-182(h)0(y)20.8(d)0(r)15.1(o)0(g)20.8(e)0(l)19.5(,)-193.5(in)20.7(st)20.9(ea)12.8(d)-191.2(o)0(f)]TJ
T*
[(an)-216.5(au)19.7(to)20.7(lo)20.7(go)15.1(us)-209.4(bo)20.8(ne)-216.5(gr)20.9(af)19.7(t,)-212(ha)19.7(s)-225.5(a)-221.1(do)20.8(ub)15.1(le)-210.8(ad)19.7(va)19.7(nt)14.9(ag)19.7(e:)-210.8(th)20.7(e)-226.9(p)0(r)20.9(i)0(m)19.5(a)0(r)19.7(y)]TJ
0 -1.1174 TD
[(su)15.3(rg)20.9(er)19.7(y)-277.6(t)0(o)-267.3(i)0(m)19.5(p)0(l)14.9(a)0(n)19.7(t)-277.7(th)20.7(e)-278.7(g)0(e)19.7(l)-277.7(wo)14.2(ul)20.7(d)-277.6(b)0(e)-268.3(n)0(o)20.8(n)0(i)20.7(n)0(v)15.1(a)0(s)19.9(i)0(v)20.7(e)-278.7(an)19.7(d)-277.6(t)0(h)14.9(e)-278.7(se)19.9(c-)]TJ
0 -1.1116 TD
[(on)15.1(da)19.7(ry)-295.9(su)15.3(rg)20.9(er)19.7(y)-312.1(t)0(o)-296.1(e)0(x)19.7(p)0(l)15(a)0(n)19.7(t)-306.5(th)15(e)-307.5(g)0(r)20.9(a)0(f)19.7(t)-312.3(wo)20(ul)20.7(d)-312.1(b)0(e)-302.9(a)0(v)19.7(o)0(i)20.7(d)0(e)19.7(d)0(.)-298.3(I)0(n)-301.7(t)0(h)20.7(e)]TJ
T*
[(de)13.9(ve)19.7(lo)20.7(pm)19.6(en)19.7(t)-490.8(o)0(f)-480.2(i)0(n)15(j)0(e)19.5(c)0(t)19.5(a)0(b)19.7(l)0(e)-481.5(h)0(y)20.8(d)0(r)15.1(o)0(g)20.8(e)0(l)19.5(s)0(,)-482.4(t)0(w)19.8(o)-490.7(ma)18.4(in)-480.4(cl)19.5(as)19.9(se)14.1(s)-490.5(o)0(f)]TJ
0 -1.1174 TD
[(ma)18.4(te)13.8(ri)20.7(al)19.5(s)-421.4(h)0(a)19.7(v)0(e)-406.5(b)0(e)13.9(e)0(n)-406.5(u)0(s)15.3(e)0(d)19.7(,)-418.1(na)19.7(tu)20.7(ra)19.7(l)-421.7(a)0(n)19.7(d)-421.6(sy)21(nt)20.7(he)19.7(ti)14.8(c)-417(p)0(o)20.8(l)0(y)15(m)0(e)18.4(r)0(s)21.1(.)]TJ
7.3823 0 0 6.5614 295.1999 280.1763 Tm
(1)Tj
9.843 0 0 9.843 59.7543 264.8692 Tm
[(Hy)14.2(al)19.5(ur)20.9(on)20.8(at)19.5(e-)]TJ
7.3823 0 0 6.5614 110.6645 269.2346 Tm
[(25)24.7(,2)20.4(6)]TJ
9.843 0 0 9.843 128.6362 264.8692 Tm
[(an)19.7(d)-173.9(c)0(h)13.9(i)0(t)20.6(o)0(s)21(a)0(n)19.7(-)]TJ
7.3823 0 0 6.5614 179.7165 269.2346 Tm
(27)Tj
9.843 0 0 9.843 188.7307 264.8692 Tm
[(ba)19.7(se)14.1(d)-173.9(h)0(y)20.8(d)0(r)20.9(o)0(g)20.8(e)0(l)-164.8(a)0(r)14(e)-175.1(ex)19.7(am)18.5(pl)20.7(es)]TJ
-13.1033 -1.1116 TD
[(of)-382.3(th)20.7(e)-388.2(f)0(o)20.9(r)0(m)19.7(e)0(r)-377.7(t)0(y)15(p)0(e)19.7(,)-383.6(wh)14.2(er)19.7(ea)18.5(s)-386.8(P)0(E)19.8(G)0(-)]TJ
7.3823 0 0 6.5614 197.4614 258.2928 Tm
[(28)24.7(3)24.7(0)]TJ
9.843 0 0 9.843 219.4015 253.9275 Tm
[(an)19.7(d)-387(P)0(L)19.8(G)0(A)19.1(-)]TJ
7.3823 0 0 6.5614 265.7196 258.2928 Tm
-.0162 Tc
(31)Tj
9.843 0 0 9.843 276.8314 253.9275 Tm
0 Tc
[(ba)19.7(se)19.9(d)]TJ
-22.0539 -1.1174 TD
[(hy)15.1(dr)20.9(og)20.8(el)19.5(s)-248.6(b)0(e)13.9(l)0(o)20.7(n)0(g)-238.3(t)0(o)-238.5(t)0(h)15(e)-249.9(la)19.6(tt)20.6(er)-245.2(ty)20.7(pe)19.7(.)]TJ
1.0137 -1.1116 TD
.0233 Tc
[(We)-549.2(hav)4.9(e)-549.2(pr)5(evi)4.8(o)4.9(us)5.1(ly)-548(d)4.9(e)3.8(vel)4.8(o)-.8(p)4.9(e)3.8(d)-553.8(s)5.1(y)4.9(n)-.8(t)4.8(h)4.9(et)4.8(i)4.8(c)-549.2(bo)4.9(ne)-549.2(g)4.9(r)5(af)5(t)]TJ
-1.0137 -1.1116 TD
0 Tc
[(PEG-based)-336.5(hydrogels)-333.5(using)-333.7(acrylate)-336.2(monomers)-329([PEGMEM)]TJ
0 -1.1174 TD
[(\(p)15.1(ol)20.7(y\()20.9(et)19.5(hy)20.8(le)13.8(ne)-331.7(gl)15(yc)19.7(ol)20.7(\))-346.6(m)0(e)18.4(t)0(h)20.7(y)0(l)-336.4(e)0(t)19.5(h)0(e)19.7(r)-346.6(me)18.4(th)20.7(ac)18.5(ry)20.9(la)19.6(te)13.8(\),)-332.8(DE)18.8(M)-347.6(\()0(2)20.9(-)]TJ
0 -1.1116 TD
[(\(d)15.1(im)19.5(et)19.6(hy)20.8(la)19.5(mi)19.5(no)20.8(\)e)14(th)20.7(yl)-353.7(me)18.4(th)20.7(ac)18.5(ry)20.9(la)19.6(te)13.8(\)])-353.5(cr)19.7(os)21(sl)15.1(in)20.7(ke)19.7(d)-364(w)0(i)19.8(t)0(h)-353.7(N)0(-)20(N)]TJ
/F9 1 Tf
23.7185 0 TD
()Tj
/F4 1 Tf
.2419 0 TD
(-)Tj
-23.9604 -1.1116 TD
[(me)18.4(th)15(yl)20.7(en)19.7(eb)19.7(is)20.9(ac)18.5(ry)15.1(la)19.6(mi)19.5(de)]TJ
7.3823 0 0 6.5614 154.3181 192.5291 Tm
-.0173 Tc
[(32)-17.3(,33)]TJ
9.843 0 0 9.843 174.6141 188.1637 Tm
0 Tc
[(th)20.7(at)-406.7(ex)19.7(hi)20.7(bi)20.7(te)13.8(d)-410(h)0(i)20.7(g)0(h)-405.4(m)0(e)18.4(c)0(h)19.7(a)0(n)19.7(i)0(c)19.6(a)0(l)]TJ
-11.6692 -1.1116 TD
[(pr)15.1(op)20.8(er)19.7(ti)20.6(es)19.9(,)-285.7(w)0(h)20(e)0(r)13.9(e)0(a)18.5(s)-283.1(ca)18.5(lc)19.6(iu)20.7(m)-284.5(p)0(h)15.1(o)0(s)21(p)0(h)20.8(a)0(t)19.5(e)-284.5(pa)19.7(rt)15(ic)19.6(le)19.6(s)-283.1(w)0(e)18.8(r)0(e)-279.8(f)0(o)20.9(r)0(m)19.6(e)0(d)]TJ
0 -1.1174 TD
-.0166 Tc
[(in)5.3(si)5.2(de)-180.1(t)5.2(h)-.4(e)-180.1(g)5.3(el)-179.1(matr)5.4(ix)5.3(,)-181.3(p)5.3(os)5.5(tg)5.3(el)5.2(i)5.5(cati)5.2(on)5.3(,)-181.3(u)5.3(si)5.2(ng)-179(a)-180.1(r)5.4(eacti)5.2(o)-.4(n)5.3()-.4(d)5.3(i)-.5(f)5.4(fus)5.5(io)5.3(n)]TJ
0 -1.1116 TD
-.0218 Tc
[(m)-6.8(e)-1(t)-5.7(h).1(o)-5.6(d).1(.)-319(I)-5.6(n)-316.6(t)-5.7(hi)-5.7(s)-322.2(w)-.7(o)-5.6(r).2(k)-5.6(,)-319(we)-323.6(de)-6.8(ve)-6.8(lo)-5.6(pe)-6.8(d)-316.6(a)-6.8(nd)]TJ
/F5 1 Tf
16.1963 0 TD
-.0215 Tc
[(in)-322.1(vi)-5.4(tr)-5.1(o)]TJ
/F4 1 Tf
3.1736 0 TD
-.0191 Tc
[(tested)-319.7(a)-315.1(n)-2.9(ew)]TJ
-19.3699 -1.1116 TD
-.0166 Tc
[(acry)5.3(late-b)5.3(as)5.5(ed)-288.4(h)5.3(y)-.4(d)5.3(r)-.4(o)5.3(g)-.4(el)5.2(s)-294(a)4.2(d)5.3(d)-.4(i)5.2(n)-.4(g)-288.4(c)4.2(al)5.2(ci)5.2(um)-283.9(ph)5.3(os)5.5(ph)5.3(at)5.2(e)-289.6(d)-.4(i)5.2(r)-.4(ect)5.2(l)-.5(y)-288.4(i)5.2(n)]TJ
0 -1.1174 TD
-.0217 Tc
[(t)-5.6(h).2(e)-242.8(g)-5.5(el)-5.6(if)-5.5(yi)-5.6(ng)-241.7(s)-5.3(o)-5.5(lu)-5.5(ti)-5.6(on)-241.7(a)-6.7(n).2(d)-241.7(s)-5.3(uc)-6.7(h)-241.7(n).2(o)-5.5(t)-241.8(re)-6.7(qu)-5.5(ir)-5.5(in)-5.5(g)-241.7(t)-5.6(he)-242.8(a)-6.7(d).2(d)-5.5(i).1(t)-5.6(i).1(on)-5.5(al)-247.6(st)-5.6(ep)]TJ
0 -1.1116 TD
-.0173 Tc
[(of)-185.4(t)4.5(h)-1.1(e)-180.8(r)-1.1(eacti)4.5(o)-1.1(n)4.6()4.6(d)-1.1(i)4.5(ffu)4.6(si)4.5(on)-179.7(pr)4.7(oces)4.8(s.)-182(Fu)4.6(rt)4.5(hermo)4.6(r)-1.1(e,)-187.8(i)4.5(n)-1.1(j)4.5(e)-2.3(ct)4.5(ab)4.6(il)4.5(it)4.5(y)-185.4(w)-2(as)]TJ
T*
-.0171 Tc
[(co)4.8(nf)4.9(er)4.9(red)-173.7(b)4.8(y)-173.7(t)4.7(he)-169.1(use)-169.1(o)-.9(f)-167.9(a)-174.9(d)4.8(i)-1(acr)4.9(y)-.9(l)4.7(a)-2.1(t)4.7(e)-174.9(est)4.7(e)-2.1(r)-167.9(a)-2.1(s)-167.8(c)-2.1(r)4.9(o)-.9(s)5(s)-.7(l)4.7(i)-1(n)4.8(k)-.9(er)-173.7(in)4.8(st)4.7(ead)-173.7(o)4.8(f)]TJ
0 -1.1174 TD
-.0153 Tc
[(N-)6.7(N)]TJ
/F9 1 Tf
1.7164 0 TD
0 Tc
()Tj
/F4 1 Tf
.2304 0 TD
-.0216 Tc
[(-m)-6.6(et)-5.5(hy)-5.4(le)-6.6(ne)-6.6(bi)-5.5(sa)-6.6(cr)-5.4(yl)-5.5(ami)-5.5(d).3(e)]TJ
7.3823 0 0 6.5614 174.5574 104.8819 Tm
-.0246 Tc
(32,33)Tj
9.843 0 0 9.843 192.9826 100.4598 Tm
-.0202 Tc
[(that)-280.6(re)-5.2(quires)-280.3(the)-275.9(r)-4(em)-5.2(oval)-280.6(of)]TJ
-13.5353 -1.1116 TD
-.0216 Tc
[(u)-5.4(n).3(r)-5.4(e)-.8(a)-6.6(c)-.8(t)-5.5(e)-.8(d)-230(m)-6.6(ol)-5.5(ecu)-5.4(le)-6.6(s)-229.8(t)-5.5(hr)-5.4(ou)-5.4(gh)-230(t)-5.5(i).2(m)-6.6(e)-.8(-)-5.4(c)-.8(on)-5.4(s)-5.2(u).3(mi)-5.5(ng)-230(d)-5.4(i).2(a)-6.6(l).2(y)-5.4(s).5(i)-5.5(s)-5.2(.)-226.6(W)-1.9(e)-237(a)-.8(ls)-5.2(o)]TJ
T*
-.017 Tc
[(ad)4.9(ded)-237(Z)3.8(n)-231.2(a)-2(n)4.9(d)-237(S)5.1(r)-236.9(t)4.8(o)-231.2(th)4.9(e)-238.1(h)4.9(yd)4.9(ro)4.9(gels)-231(as)-231(th)4.9(ey)-231.2(are)-232.4(k)-.8(n)4.9(o)-.8(wn)-237(t)4.8(o)-231.2(en)4.9(hance)]TJ
0 -1.1174 TD
[(os)5(teob)4.8(last)-243(g)4.8(r)-.9(o)4.8(w)-1.8(t)4.7(h)]TJ
7.3823 0 0 6.5614 126.5385 72 Tm
-.0239 Tc
(34)Tj
9.843 0 0 9.843 135.9496 67.5779 Tm
-.0216 Tc
[(a)-6.6(n).3(d)-247.3(d)-5.4(emo)-5.4(n).3(s)-5.2(t)-5.5(ra)-6.6(te)-248.5(th)-5.4(at)-247.5(t)-5.5(h).3(e)-6.6(s).5(e)-248.5(i)-5.5(on)-5.4(s)-247.1(a)-6.6(ls)-5.2(o)-247.3(c)-.8(o)-5.4(n).3(f)-5.4(e)-.8(r)]TJ
-7.741 -1.1116 TD
-.0163 Tc
[(an)5.6(ti)5.5(mi)5.5(cr)5.7(ob)5.6(ial)-259.4(p)5.6(ro)5.6(pert)]TJ
8.1385 0 TD
-.017 Tc
[(ies)-259.8(t)4.8(o)-260(t)4.8(he)-255.4(materi)4.8(al)4.8(.)]TJ
/F6 1 Tf
8.9663 0 0 8.9663 310.8472 725.7825 Tm
0 Tc
[(Materials)-332.7(and)-331.9(Methods)]TJ
/F10 1 Tf
0 -1.8336 TD
(Materials)Tj
/F4 1 Tf
9.843 0 0 9.843 320.8251 692.9006 Tm
[(PEGMEM)-288([poly\(ethylene)-290(glycol\))-291.3(methyl)-285.7(ether)-290.2(methacry-)]TJ
-1.0137 -1.1116 TD
[(late])-284.5(with)-287.8(average)-288.8(Mn)]TJ
/F9 1 Tf
9.1061 0 TD
(=)Tj
/F4 1 Tf
.7142 0 TD
[(300,)-289(DEM)-282.7([2-\(dimethy)-8.9(lamino\)ethyl)]TJ
-9.8203 -1.1174 TD
[(methacrylate],)-635.7(1,4-butanediol)-631(dimethacrylate,)-631.2(ammonium)]TJ
0 -1.1116 TD
[(persulfate)-337(\(APS\),)-337.7(ZnCl)]TJ
7.3823 0 0 6.5614 403.6534 658.3746 Tm
(2)Tj
9.843 0 0 9.843 407.3385 660.0187 Tm
[(,)-337.5(SrCl)]TJ
7.3823 0 0 6.5614 431.1495 658.3746 Tm
(2,)Tj
9.843 0 0 9.843 439.9936 660.0187 Tm
[(glutaraldehyde,)-340.7(acetic)-339.8(acid,)]TJ
-13.1206 -1.1116 TD
[(Thiazolyl)-376.7(Blue)-381.1(Tetrazolium)-381.2(Bromide)-379.9(\()-81.7(MTT\),)-379.7(and)-378.8(Alizarin)]TJ
0 -1.1174 TD
[(Red)-385.6(S)-386.8(were)-393.5(purchased)-387.6(from)-391.5(Sigma-Aldrich.)]TJ
/F11 1 Tf
18.6557 0 TD
(a)Tj
/F4 1 Tf
.5529 0 TD
(-Tricalcium-)Tj
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T*
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T*
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T*
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[(remained)-451.4(immersed)-457(in)-445.8(SBF)-453.3(at)-447(37)]TJ
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[(C)-341.9(using)-345.3(an)-343.2(Edwards)-344.8(Modulyo)-348.6(Freeze)]TJ
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[(Dryer.)-368(X-ray)-370.3(diffraction)-366.1(\(XRD\))-371.1(patterns)-368.3(were)-370.4(acquired)-369.5(us-)]TJ
T*
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T*
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[(Scanning)-383.2(electron)-386.5(microscope.)]TJ
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T*
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T*
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T*
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T*
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T*
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25.5097 18.2583 TD
[(value)-474.5(close)-480.1(to)-474.6(0)]TJ
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T*
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T*
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