Plasma miR-124-3p and miR-16 concentrations as prognostic markers in acute stroke

Rainer, Timothy ORCID: https://orcid.org/0000-0003-3355-3237, Leung, Ling Yan, Chan, Cangel Pui Yee, Leung, Yuk Ki, Abrigo, Jill Morales, Wang, Defeng and Graham, Colin A. 2016. Plasma miR-124-3p and miR-16 concentrations as prognostic markers in acute stroke. Clinical Biochemistry 49 (9) , pp. 663-668. 10.1016/j.clinbiochem.2016.02.016

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Abstract

Objectives This study aimed to investigate plasma concentrations of miR-124-3p and miR-16 as prognostic markers in emergency department patients with acute stroke. Design and methods Plasma concentrations of miR-124-3p and miR-16 of 84 stroke patients (presenting to the emergency department within 24 h from onset of symptoms) were determined by RT-qPCR. The primary outcome measure was 3-month mortality and the secondary outcome measure was post-stroke modified Rankin Score (mRS). Results Twelve patients (14.3%) died within 3 months of hospital admission and forty-one (48.8%) patients as achieved a 3-month mRS > 2. Median plasma miR-124-3p concentrations were elevated in patients who died compared to patients who survived (p = 0.0052), and its levels were found to be higher in patients with a 3-month mRS > 2 compared with patients with mRS ≤ 2 (p = 0.0312). Higher plasma miR-16 concentrations were observed in patients who survived than in patients who died (p = 0.0394), while its concentrations were lower in patients achieving mRS > 2 than in patients with mRS ≤ 2 (p = 0.0124). For a subgroup of cases presenting to the emergency department within 6 h from time of symptom onset (n = 36), plasma miR-124-3p concentrations predicted 3-month mortality with an area under the ROC curve of 0.87 (95%CI: 0.72–0.96). Conclusions Plasma miR-124-3p and miR-16 are molecular markers which could be useful for the early prediction of mortality and mRS.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Uncontrolled Keywords:	microRNA; Stroke; Plasma; Prognosis
Publisher:	Elsevier
ISSN:	0009-9120
Date of First Compliant Deposit:	20 July 2016
Date of Acceptance:	24 February 2016
Last Modified:	01 Nov 2022 10:50
URI:	https://orca.cardiff.ac.uk/id/eprint/93017

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