Asymmetry of white matter pathways in developing human brains

Song, Jae W., Mitchell, Paul D., Kolasinski, James ORCID: https://orcid.org/0000-0002-1599-6440, Grant, P. Ellen, Galaburda, Albert M. and Takahashi, Emi 2015. Asymmetry of white matter pathways in developing human brains. Cerebral Cortex 25 (9) , pp. 2883-2893. 10.1093/cercor/bhu084

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Abstract

Little is known about the emergence of structural asymmetry of white matter tracts during early brain development. We examined whether and when asymmetry in diffusion parameters of limbic and association white matter pathways emerged in humans in 23 brains ranging from 15 gestational weeks (GW) up to 3 years of age (11 ex vivo and 12 in vivo cases) using high-angular resolution diffusion imaging tractography. Age-related development of laterality was not observed in a limbic connectional pathway (cingulum bundle or fornix). Among the studied cortico-cortical association pathways (inferior longitudinal fasciculus [ILF], inferior fronto-occipital fasciculus, and arcuate fasciculus), only the ILF showed development of age-related laterality emerging as early as the second trimester. Comparisons of ages older and younger than 40 GW revealed a leftward asymmetry in the cingulum bundle volume and a rightward asymmetry in apparent diffusion coefficient and leftward asymmetry in fractional anisotropy in the ILF in ages older than 40 GW. These results suggest that morphometric asymmetry in cortical areas precedes the emergence of white matter pathway asymmetry. Future correlative studies will investigate whether such asymmetry is anatomically/genetically driven or associated with functional stimulation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > Q Science (General)
Uncontrolled Keywords:	Asymmetry; Brain; Development; Diffusion imaging; Human; Tractography; White matter
Publisher:	Oxford University Press
ISSN:	1047-3211
Last Modified:	02 Nov 2022 10:13
URI:	https://orca.cardiff.ac.uk/id/eprint/97867

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