Indications for treatment of subclinical hypothyroidism and isolated hypothyroxinaemia in pregnancy

Taylor, Peter N. ORCID: https://orcid.org/0000-0002-3436-422X, Muller, Ilaria ORCID: https://orcid.org/0000-0003-2926-0722, Nana, Melanie, Velasco, Ines and Lazarus, John H. 2020. Indications for treatment of subclinical hypothyroidism and isolated hypothyroxinaemia in pregnancy. Best Practice and Research: Clinical Endocrinology and Metabolism 34 (4) , 101436. 10.1016/j.beem.2020.101436

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Abstract

Thyroid hormones are essential for maintaining a pregnancy and optimal fetal neurological development. Pregnancy places additional demands on the thyroid axis and around 5% of women who have their thyroid function checked during gestation will have borderline low thyroid function (subclinical hypothyroidism or isolated hypothyroxinemia) identified. These borderline low thyroid states are associated with adverse obstetric and offspring outcomes. Whilst it is well established that overt hypothyroidism requires treatment with levothyroxine, it is less clear whether there is any benefit of treating borderline low thyroid states. This review summarizes the potential indications for treatment of subclinical hypothyroidism and isolated hypothyroxinemia.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Elsevier
ISSN:	1521-690X
Last Modified:	09 Nov 2022 09:31
URI:	https://orca.cardiff.ac.uk/id/eprint/136023

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