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CRIB - the use of cardiac rehabilitation services to aid the recovery of patients with bowel cancer: a pilot randomised controlled trial (RCT) with embedded feasibility study

Munro, Julie, Adams, Richard, Campbell, Anna, Campbell, Sandra, Donaldson, Cam, Godwin, Jon, Haw, Sally, Kidd, Lisa, Lane, Chrissie, Leslie, Stephen J, Mason, Helen, Mutrie, Nanette, O'Carroll, Ronan, Taylor, Cara, Treweek, Shaun, Watson, Angus and Hubbard, Gill 2014. CRIB - the use of cardiac rehabilitation services to aid the recovery of patients with bowel cancer: a pilot randomised controlled trial (RCT) with embedded feasibility study. BMJ Open 4 (2) , e004684. 10.1136/bmjopen-2013-004684

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Introduction: Patients with colorectal cancer reportongoing physical and psychological impairments and ahigh proportion of these patients are overweight,insufficiently active and high-risk drinkers, puttingthem at risk of poor recovery and risk of recurrenceand comorbidities. A challenge is implementingsustainable and effective rehabilitation as part ofroutine care for this group.Methods and analysis: A two-arm pilot randomisedcontrolled trial (RCT) with embedded feasibility studyundertaken as a phased programme of work. Theintervention involves an existing cardiac rehabilitationprogramme for cardiac patients accepting colorectalcancer patient referrals. The intervention consists ofsupervised exercise sessions run by a cardiacphysiotherapist and information sessions. Phase 1 willinvolve one research site enrolling 12 patients toassess intervention and study design processes.Semistructured interviews with patients with colorectalcancer and cardiac patients and clinicians will be usedto gather data on acceptability of the intervention andstudy procedures. Phase 2 will involve three sitesenrolling 66 patients with colorectal cancer randomisedto control or intervention groups. Outcome measureswill be taken preintervention and postintervention, forphases 1 and 2. The primary outcome is accelerometermeasured physical activity; secondary outcomes areself-report physical activity, quality of life, anxiety,depression, symptoms including fatigue. The followingvariables will also be examined to determine if thesefactors influence adherence and outcomes: selfefficacy, risk perception and treatments.Ethics and dissemination: Full ethical approval wasgranted by NRES Committees—North of Scotland(13/NS/0004; IRAS project ID: 121757) on 22 February2013. The proposed work is novel in that it aims totest the feasibility and acceptability of using anevidence-based and theory driven existing cardiacrehabilitation service with patients with colorectalcancer. Should this model of rehabilitation prove to beclinically and cost effective we aim to conduct arandomised controlled trial of this intervention tomeasure effectiveness.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Centre for Trials Research (CNTRR)
Publisher: BMJ Publishing Group
ISSN: 2044-6055
Date of First Compliant Deposit: 4 June 2021
Date of Acceptance: 4 January 2014
Last Modified: 04 Jun 2021 09:15

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