Connecting the "dots": RNP granule network in health and disease

An, Haiyan, de Meritens, Camille Rabesahala and Shelkovnikova, Tatyana A. ORCID: https://orcid.org/0000-0003-1367-5309 2021. Connecting the "dots": RNP granule network in health and disease. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1868 (8) , 119058. 10.1016/j.bbamcr.2021.119058

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Abstract

All cells contain ribonucleoprotein (RNP) granules – large membraneless structures composed of RNA and proteins. Recent breakthroughs in RNP granule research have brought a new appreciation of their crucial role in organising virtually all cellular processes. Cells widely exploit the flexible, dynamic nature of RNP granules to adapt to a variety of functional states and the ever-changing environment. Constant exchange of molecules between the different RNP granules connects them into a network. This network controls basal cellular activities and is remodelled to enable efficient stress response. Alterations in RNP granule structure and regulation have been found to lead to fatal human diseases. The interconnectedness of RNP granules suggests that the RNP granule network as a whole becomes affected in disease states such as a representative neurodegenerative disease amyotrophic lateral sclerosis (ALS). In this review, we summarize available evidence on the communication between different RNP granules and on the RNP granule network disruption as a primary ALS pathomechanism.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Additional Information:	This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Publisher:	Elsevier
ISSN:	0167-4889
Date of First Compliant Deposit:	21 May 2021
Date of Acceptance:	7 May 2021
Last Modified:	04 May 2023 23:15
URI:	https://orca.cardiff.ac.uk/id/eprint/141511

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