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Recent advancements in the exploitation of the gut microbiome in the diagnosis and treatment of colorectal cancer

Stott, Katie J., Phillips, Bethan, Parry, Lee and May, Stephanie 2021. Recent advancements in the exploitation of the gut microbiome in the diagnosis and treatment of colorectal cancer. Bioscience Reports 41 (7) , BSR20204113. 10.1042/BSR20204113

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Abstract

Over the last few decades it has been established that the complex interaction between the host and the multitude of organisms that compose the intestinal microbiota plays an important role in human metabolic health and disease. Whilst there is no defined consensus on the composition of a healthy microbiome due to confounding factors such as ethnicity, geographical locations, age and sex, there are undoubtedly populations of microbes that are consistently dysregulated in gut diseases including colorectal cancer (CRC). In this review, we discuss the most recent advances in the application of the gut microbiota, not just bacteria, and derived microbial compounds in the diagnosis of CRC and the potential to exploit microbes as novel agents in the management and treatment of CRC. We highlight examples of the microbiota, and their derivatives, that have the potential to become standalone diagnostic tools or be used in combination with current screening techniques to improve sensitivity and specificity for earlier CRC diagnoses and provide a perspective on their potential as biotherapeutics with translatability to clinical trials.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
European Cancer Stem Cell Research Institute (ECSCRI)
Publisher: Portland Press
ISSN: 0144-8463
Funders: CRUK
Date of First Compliant Deposit: 7 July 2021
Date of Acceptance: 7 July 2021
Last Modified: 31 Jan 2022 07:23
URI: https://orca.cardiff.ac.uk/id/eprint/142469

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