Mechanical activation of zero-valent metal reductants for nickel-catalyzed cross-electrophile coupling

Jones, Andrew C., Williams, Matthew T. J., Morrill, Louis C. ORCID: https://orcid.org/0000-0002-6453-7531 and Browne, Duncan L. ORCID: https://orcid.org/0000-0002-8604-229X 2022. Mechanical activation of zero-valent metal reductants for nickel-catalyzed cross-electrophile coupling. ACS Catalysis 12 (21) , pp. 13681-13689. 10.1021/acscatal.2c03117

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Abstract

The cross-electrophile coupling of either twisted-amides or heteroaryl halides with alkyl halides, enabled by ball-milling, is herein described. The operationally simple nickel-catalyzed process has no requirement for inert atmosphere or dry solvents and delivers the corresponding acylated or heteroarylated products across a broad range of substrates. Key to negating the necessity of inert reaction conditions is the mechanical activation of the raw metal terminal reductant: manganese in the case of twisted amides and zinc for heteroaryl halides.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Cardiff Catalysis Institute (CCI)
Additional Information:	License information from Publisher: LICENSE 1: URL: https://creativecommons.org/licenses/by/4.0/, Start Date: 2022-10-25
Publisher:	American Chemical Society
ISSN:	2155-5435
Date of First Compliant Deposit:	8 November 2022
Date of Acceptance:	17 October 2022
Last Modified:	23 May 2023 03:22
URI:	https://orca.cardiff.ac.uk/id/eprint/154041

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