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BOLD PSF: Impact of k-space sampling on T2* contrast

Engel, Maria ORCID:, Kasper, Lars and Pruessmann, Klaas Paul 2022. BOLD PSF: Impact of k-space sampling on T2* contrast. Presented at: Joint Annual Meeting ISMRM-ESMRMB, London, 7-12 May 2022.

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The timing of BOLD-fMRI is typically chosen such that TE matches T2*. This assumes contrast being exclusively elicited by signal differences at TE. While sensible for short or TE-symmetric readouts, such as EPIs, it oversimplifies contrast generation for longer or TE-asymmetric trajectories, such as spirals. We propose the concept of a BOLD PSF for a more comprehensive perspective on the imaging characteristics of a functional experiment. Our findings indicate that TE can be reduced for spiral-out without sacrificing BOLD-sensitivity when compared to EPI. Furthermore, we characterize the intrinsic trade-off between specificity and resolution of the BOLD response under varying TE.

Item Type: Conference or Workshop Item (Poster)
Status: Published
Schools: Psychology
Date of Acceptance: 2022
Last Modified: 02 Feb 2023 02:17

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