Synthesis of Chiral Iodoaniline-Lactate Based Catalysts for the α-Functionalization of Ketones

Alkahtani, Rawiyah and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2023. Synthesis of Chiral Iodoaniline-Lactate Based Catalysts for the α-Functionalization of Ketones. ACS Organic & Inorganic Au 3 (4) , pp. 209-216. 10.1021/acsorginorgau.3c00012

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Abstract

A family of chiral iodoaniline-lactate based catalysts with C1 and C2 symmetry were efficiently synthesized. Comparisons between the reactivity and selectivity between the new and previously reported catalysts are made. The new catalysts promoted the α-oxysulfonylation of ketones in shorter reaction times and with higher yields of up to 99%. A scope for the oxysulfonylation reaction is presented, forming a variety of reported and novel products with enantioselectivities of up to 83%.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	American Chemical Society
ISSN:	2694-247X
Funders:	Saudi Arabian Government
Date of First Compliant Deposit:	19 May 2023
Date of Acceptance:	25 April 2023
Last Modified:	23 Jan 2024 14:47
URI:	https://orca.cardiff.ac.uk/id/eprint/159724

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