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The S-cone electroretinogram: a comparison of techniques, normative data and age-related variation

Chiti, Zohreh, North, Rachel Valerie ORCID:, Mortlock, Katharine Eirlys ORCID: and Drasdo, Neville 2003. The S-cone electroretinogram: a comparison of techniques, normative data and age-related variation. Ophthalmic And Physiological Optics 23 (4) , pp. 370-376. 10.1046/j.1475-1313.2003.00129.x

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The blue sensitive mechanism in human colour vision is highly susceptible to damage in ocular disease. There is a need for objective methods to assess this and several methods of recording the blue cone (S-cone) electroretinogram (ERG) have been described. We therefore compared a silent substitution technique (SST) and a selective adaptation technique (SAT) using a novel combination of optical filters, on 24 normal subjects. The age-related variation in the S-cone ERG was also investigated in a further 73 normal subjects. S-cone ERGs elicited by SAT were of higher amplitude, (p < 0.001) with smaller coefficients of variation than those elicited with SST. The SST method has already been shown to be highly sensitive in primary open angle glaucoma and, unlike SAT, has no significant age related variation. However, the results of this study suggest that the new, SAT method may prove to be more convenient and effective in clinical practice, provided that age norms are applied.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Uncontrolled Keywords: electroretinogram; S-cone; selective adaptation technique; silent substitution technique
Publisher: Blackwell Publishing
ISSN: 0275-5408
Last Modified: 25 Oct 2022 08:41

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