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Anxiety and depressive symptoms in childhood - a genetic study of comorbidity

Thapar, Anita ORCID: and McGuffin, Peter 1997. Anxiety and depressive symptoms in childhood - a genetic study of comorbidity. Journal of Child Psychology and Psychiatry 38 (6) , pp. 651-656. 10.1111/j.1469-7610.1997.tb01692

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Anxiety and depressive symptoms commonly co-occur yet the underlying mechanisms for this covariation remain poorly understood. Genetic strategies are a useful means of investigating whether the comorbidity of two sets of symptoms or disorders can be explained by the same aetiological factors. In this paper we use a systematically ascertained sample of 172 twin pairs aged 8 to 16 years to examine the causes of covariation of maternally rated anxiety and depressive symptoms. The results suggest that most of the covariation can be explained by a common set of genes that influence anxiety and depressive symptoms. Some covariation between anxiety and depressive symptoms is also explained by environmental influences of the non-shared type. In addition, depressive symptoms also appear to be influenced by specific genetic factors.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Depression; anxiety; comorbidity; genetics
Publisher: Wiley-Blackwell
ISSN: 1469-7610
Last Modified: 31 Oct 2022 09:59

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