Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Drug-polymer intermolecular interactions in hot-melt extruded solid dispersions

Maniruzzaman, Mohammed, Morgan, David J. ORCID: https://orcid.org/0000-0002-6571-5731, Mendham, Andrew P., Pang, Jiayun, Snowden, Martin J. and Douroumis, Dennis 2013. Drug-polymer intermolecular interactions in hot-melt extruded solid dispersions. International Journal of Pharmaceutics 443 (1-2) , pp. 199-208. 10.1016/j.ijpharm.2012.11.048

Full text not available from this repository.

Abstract

The purpose of the study was to investigate and identify the interactions within solid dispersions of cationic drugs and anionic polymers processed by hot-melt extrusion (HME) technique. Propranolol HCl (PRP) and diphenhydramine HCl (DPD) were used as model cationic active substances while pH sensitive anionic methacrylic acid based methyl methacrylate copolymers Eudragit L100® (L100) and ethyl acrylate copolymer Eudragit L100-55 (Acryl EZE) (L100-55) were used as polymeric carriers. The extrudates were further characterised using various physicochemical characterisation techniques to determine the morphology, the drug state within the polymer matrices and the type of drug–polymer interactions. Molecular modelling predicted the existence of two possible H-bonding types while the X-ray photon spectroscopy (XPS) advanced surface analysis of the extrudates revealed intermolecular ionic interactions between the API amino functional groups and the polymer carboxylic groups through the formation of hydrogen bonding. The magnitude of the intermolecular interactions varied according to the drug–polymer miscibility.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Cardiff Catalysis Institute (CCI)
Publisher: Elsevier
ISSN: 0378-5173
Last Modified: 07 Nov 2022 10:40
URI: https://orca.cardiff.ac.uk/id/eprint/133145

Citation Data

Cited 129 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item