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Human osteopontin: potential clinical applications in cancer (Review)

Hao, Chengcheng, Cui, Yuxin, Owen, Sionen, Li, Wenbin, Cheng, Shan and Jiang, Wen Guo 2017. Human osteopontin: potential clinical applications in cancer (Review). International Journal of Molecular Medicine 10.3892/ijmm.2017.2964

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Human osteopontin (OPN) is a glycosylated phosphoprotein which is expressed in a variety of tissues in the body. In recent years, accumulating evidence has indicated that the aberrant expression of OPN is closely associated with tumourigensis, progression and most prominently with metastasis in several tumour types. In this review, we present the current knowledge on the expression profiles of OPN and its main splice variants in human cancers, as well as the potential implications in patient outcome. We also discuss its putative clinical application as a cancer biomarker and as a therapeutic target.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher: Spandidos Publications
ISSN: 1107-3756
Funders: cancer research Wales, cardiff university china medical Scholarship, life Science research network for Wales (lSrnW) and the Albert Hung foundation
Date of First Compliant Deposit: 24 April 2017
Date of Acceptance: 10 April 2017
Last Modified: 09 Jan 2018 13:15

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