Mnemonic strategy training of the elderly at risk for dementia enhances integration of information processing via cross-frequency coupling

Dimitriadis, Stavros ORCID: https://orcid.org/0000-0002-0000-5392, Tarnanas, Ioannis, Wiederhold, Mark, Wiederhold, Brenda, Tsolaki, Magda and Fleisch, Elgar 2016. Mnemonic strategy training of the elderly at risk for dementia enhances integration of information processing via cross-frequency coupling. Alzheimer's & Dementia: Translational Research & Clinical Interventions 2 (4) , pp. 241-249. 10.1016/j.trci.2016.08.004

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Abstract

Introduction: We sought to identify whether intensive 10-week mobile health mnemonic strategy training (MST) could shift the resting-state brain network more toward cortical-level integration, which has recently been proven to reflect the reorganization of the brain networks compensating the cognitive decline. Methods: One hundred fifty-eight patients with mild cognitive impairment (MCI) were selected and participated in 10-week training lasting 90 min/d of memory training. They benefited from an initial and a follow-up neuropsychological evaluation and resting-state electroencephalography (EEG). Results: At follow-up, MST revealed an extensive significant training effect that changed the network with an increase of synchronization between parietotemporal and frontal areas; frontalq - parietala2 causal strengthening as part of top-down inhibitory control; enhancement of sensorimotor connections in b band; and a general increase of cortical-level integration. More precisely, MST induced gain as an increase of the global cost efficiency (GCE) of the whole cortical network and a neuropsychological performance improvement, which was correlated with it (r 5 0.32, P 5 .0001). The present study unfolded intervention changes based on EEG source activity via novel neuroinformatic tools for revealing intrinsic coupling modes in both amplitude-phase representations and in the mixed spectrospatiotemporal domain. Discussion: Further work should identify whether the GCE enhancement of the functional cortical brain networks is a compensation mechanism to the brain network dysfunction or a more permanent neuroplasticity effect.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Advanced Research Computing @ Cardiff (ARCCA) Cardiff University Brain Research Imaging Centre (CUBRIC) MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Psychology
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Older adults; Cognitive training; Cognitive function; Physical activity; Augmented reality; Brain plasticity; Intrinsic coupling modes
Publisher:	Elsevier
ISSN:	2352-8737
Date of First Compliant Deposit:	2 May 2017
Date of Acceptance:	15 September 2016
Last Modified:	04 May 2023 23:58
URI:	https://orca.cardiff.ac.uk/id/eprint/100246

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