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Selective fluorescent detection of RNA in living cells by using imidazolium-based cyclophane

Shirinfar, Bahareh, Ahmed, Nisar, Park, Yu Shin, Cho, Gun-Sik, Youn, Il Seung, Han, Jin-Kwan, Nam, Hong Gil and Kim, Kwang S. 2013. Selective fluorescent detection of RNA in living cells by using imidazolium-based cyclophane. Journal of the American Chemical Society 135 (1) , pp. 90-93. 10.1021/ja3112274

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Abstract

A water-soluble imidazolium-based fluorescent chemosensor senses RNA selectively through fluorescence enhancement over other biologically relevant biomolecules in aqueous solution at physiological pH 7.4. Fluorescence image detection of RNA in living cells such as onion cells, HeLa cells, and animal model cells was successfully demonstrated which displays a chelation-enhanced fluorescence effect. These affinities can be attributed to the strong electrostatic (C–H)+···A– ionic H-bonding and the aromatic moiety driven π-stacking of imidazolium-based cyclophane with the size-complementary major groove of RNA.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: American Chemical Society
ISSN: 0002-7863
Last Modified: 04 Jun 2017 09:49
URI: http://orca.cardiff.ac.uk/id/eprint/100423

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