A role for chromatin remodeling in transcriptional termination by RNA polymerase II

Alen, Claudia, Kent, Nicholas A. ORCID: https://orcid.org/0000-0002-4114-1307, Jones, Hannah S., O'Sullivan, Justin, Aranda, Agustin and Proudfoot, Nicholas J. 2002. A role for chromatin remodeling in transcriptional termination by RNA polymerase II. Molecular Cell 10 (6) , pp. 1441-1452. 10.1016/S1097-2765(02)00778-5

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Abstract

Chromatin remodeling can facilitate the recruitment of RNA polymerase II (Pol II) to targeted promoters, as well as enhancing the level of transcription. Here, we describe a further key role for chromatin remodeling in transcriptional termination. Using a genetic screen in S. pombe, we identified the CHD-Mi2 class chromatin remodeling ATPase, Hrp1, as a termination factor. In S. cerevisiae, we show that transcriptional termination and chromatin structure at the 3′ ends of three genes all depend on the activity of the Hrp1 homolog, Chd1p, either alone or redundantly with the ISWI ATPases, Isw1p, and Isw2p. We suggest that chromatin remodeling of termination regions is a necessary prelude to efficient Pol II termination.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Cell Press
ISSN:	1097-2765
Last Modified:	17 Oct 2022 08:46
URI:	https://orca.cardiff.ac.uk/id/eprint/1022

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