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Directed lithiation and substitution of pyridine derivatives

El-Hiti, Gamal A., Smith, Keith and Hegazy, Amany S. 2015. Directed lithiation and substitution of pyridine derivatives. Heterocycles 91 (3) , pp. 479-504.

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Directed lithiation of substituted pyridines containing a directing metalating group (DMG) with a lithium reagent in anhydrous solvent at low temperature gives the corresponding lithium intermediates in-situ, which on reactions with electrophiles produce the corresponding substituted derivatives. The method is simple, general, convenient and often high yielding.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Chemistry
Publisher: Elsevier
ISSN: 0385-5414
Last Modified: 01 Sep 2017 12:03

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