Analysis of fascin-1 in relation to gleason risk classification and nuclear ets-related gene status of human prostate carcinomas: an immunohistochemical study of clinically annotated tumours from the Wales Cancer Bank

Jefferies, Matthew T., Pope, Christopher, Kynaston, Howard ORCID: https://orcid.org/0000-0003-1902-9930, Clarke, Alan R., Martin, Richard and Adams, Josephine 2017. Analysis of fascin-1 in relation to gleason risk classification and nuclear ets-related gene status of human prostate carcinomas: an immunohistochemical study of clinically annotated tumours from the Wales Cancer Bank. Biomarkers in Cancer 9 , pp. 1-8. 10.1177/1179299X17710944

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Abstract

Although prostate-specific antigen (PSA) testing can identify early-stage prostate cancers, additional biomarkers are needed for risk stratification. In one study, high levels of the actin-bundling protein, fascin-1, were correlated with lethal-phase, hormone-refractory prostate cancer. Analyses of independent samples are needed to establish the value of fascin-1 as a possible biomarker. We examined fascin-1 by immunohistochemistry in tumour specimens from the Wales Cancer Bank in comparison with nuclear-located ETS-related gene (ERG), an emerging marker for aggressive prostate cancer. Fascin-1 was elevated in focal areas of a minority of tumours, yet fascin-1-positivity did not differentiate tumours of low-, intermediate-, or high-risk Gleason scores and did not correlate with PSA status or biochemical relapse after surgery. Stromal fascin-1 correlated with high Gleason score. Nuclear ERG was upregulated in tumours but not in stroma. The complexities of fascin-1 status indicate that fascin-1 is unlikely to provide a suitable biomarker for prediction of aggressive prostate cancers

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Uncontrolled Keywords:	Fascin, ERG, prostate cancer, tumour progression, PSA, Gleason
Publisher:	Sage
ISSN:	1179-299X
Date of First Compliant Deposit:	25 July 2017
Date of Acceptance:	21 April 2017
Last Modified:	04 May 2023 14:33
URI:	https://orca.cardiff.ac.uk/id/eprint/102588

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